scholarly journals Direct Determination of Lean Body Mass by CT in F-18 FDG PET/CT Studies: Comparison with Estimates Using Predictive Equations

2013 ◽  
Vol 47 (2) ◽  
pp. 98-103 ◽  
Author(s):  
Chang Guhn Kim ◽  
Woo Hyoung Kim ◽  
Myoung Hyoun Kim ◽  
Dae-Weung Kim
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Fdg Pet ◽  
Direct Determination ◽  
Predictive Equations ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Ct Studies

RA07.06: BASELINE FDG-PET/CT PARAMETERS AS PREDICTOR FOR RESIDUAL TUMOUR AFTER NEOADJUVANT CHEMORADIOTHERAPY IN OESOPHAGEAL CANCER PATIENTS

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 35-35
Author(s):  
Maria Valkema ◽  
B Noordman ◽  
Bas P L Wijnhoven ◽  
M C W Spaander ◽  
Sjoerd M Lagarde ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Lean Body Mass ◽  
Body Mass ◽  
Oesophageal Cancer ◽  
Fdg Pet ◽  
Neoadjuvant Chemoradiotherapy ◽  
Tumour Mass ◽  
Residual Tumour ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract Background An optimal model for predicting pathologic response after neoadjuvant chemoradiotherapy (nCRT) in oesophageal cancer has not been defined yet. FDG-PET/CT is frequently used in response assessments. The aim of this side study of the preSANO trial (NL41732.078.13) was to investigate if the FDG-PET parameters SUVmax, total lesion glycolysis (TLG) and metabolic tumour volume (MTV) were predictive for residual tumour in the resected specimen of oesophageal cancer patients treated with nCRT. Methods Patients underwent FDG-PET/CT at baseline according to the European Association of Nuclear Medicine guidelines 1.0 (2.3MBq/kg F-18-FDG; scanning 60 ± 5min.). All parameters were corrected for lean body mass. MTV was defined as the volume within a 41% of SULmax ( = SUV/lean body mass) isocontour threshold at tumour and lymph nodes. TLG was calculated as SULmean x MTV. Logarithmic transformation was performed because of non-normal distribution of TLG and MTV. Baseline PET parameters were compared to tumour regression grade in the resection specimen (TRG3–4 = > 10% residual tumour vs. TRG1 = complete response). Peroperatively irresectable tumours were recoded as TRG4. Analyses were performed using an independent-samples T-test. Results From a total of 207 patients who underwent FDG-PET/CT before nCRT, 197 were included for analysis (5 were non-FDG avid, 5 had incomplete data). Histological type of tumour: adenocarcinoma (AC) n = 154, squamous cell carcinoma (SCC) n = 42, and one adenosquamous carcinoma. Thirty-seven patients (19%) had TRG1 and 41 patients (21%) had TRG3–4. In complete responders (TRG1), SULmax, TLG and MTV (mean ± SD) were 9.6 ± 5.8, 85.3 ± 85.5 and 13.0 ± 9.9, respectively. In patients with TRG3–4, SULmax, TLG and MTV were 9.4 ± 5.4145.8 ± 164.6 and 21.9 ± 16.2, respectively. SULmax was not significantly different between both groups (P = 0.8), but log(TLG) and log(MTV) (P = 0.008 and P = 0.001) were. In adenocarcinomas, log(TLG) did not differ between groups (P = 0.1). Conclusion Initial FDG tumour mass, expressed as MTV, (rather than SULmax) is the most contributing factor in predicting residual disease after nCRT in both SCC and AC. The effect is stronger in SCC. Therefore, baseline FDG tumour mass should be included in a prediction model, besides other clinical and tumour parameters. Disclosure All authors have declared no conflicts of interest.

scholarly journals Reliability of standardized uptake value normalized to lean body mass using the liver as a reference organ, in contrast-enhanced 18F-FDG PET/CT imaging

2018 ◽  
Vol 147 ◽  
pp. 35-39 ◽  
Author(s):  
Nur Hafizah Mohad Azmi ◽  
Subapriya Suppiah ◽  
Chang Wing Liong ◽  
Noramaliza Mohd Noor ◽  
Salmiah Md. Said ◽  
...  
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Ct Imaging ◽  
Contrast Enhanced ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Liver Standardized Uptake Value Corrected for Lean Body Mass at FDG PET/CT

2015 ◽  
Vol 40 (1) ◽  
pp. e17-e22 ◽  
Author(s):  
Alin Chirindel ◽  
Krishna C. Alluri ◽  
Abdel K. Tahari ◽  
Muhammad Chaudhry ◽  
Richard L. Wahl ◽  
...  
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals The Effect of New Formulas for Lean Body Mass on Lean-Body-Mass–Normalized SUV in Oncologic 18F-FDG PET/CT

2018 ◽  
Vol 46 (3) ◽  
pp. 253-259
Author(s):  
Trygve Halsne ◽  
Ebba Glørsen Müller ◽  
Ann-Eli Spiten ◽  
Alexander Gul Sherwani ◽  
Lars Tore Gyland Mikalsen ◽  
...  
Keyword(s):  
Lean Body Mass ◽  
Body Mass ◽  
Fdg Pet ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Incidental focal colonic uptake on 18 F-FDG PET/CT studies

2018 ◽  
Vol 37 (1) ◽  
pp. 15-19
Author(s):  
L. Servente ◽  
V. Gigirey ◽  
M. García Fontes ◽  
O. Alonso
Keyword(s):  
Fdg Pet ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Ct Studies

scholarly journals Dynamic PET/CT Imaging of 68Ga-FAPI-04 in Chinese Subjects

2021 ◽  
Vol 11 ◽  
Author(s):  
Shuailiang Wang ◽  
Xin Zhou ◽  
Xiaoxia Xu ◽  
Jin Ding ◽  
Teli Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Patients ◽  
Body Mass ◽  
Fdg Pet ◽  
Radiation Dosimetry ◽  
Ct Imaging ◽  
Lung Cancer Patients ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Chinese Subjects

This study aims to further explore dynamic 68Ga-FAPI-04 PET/CT imaging of healthy Chinese subjects and lung cancer patients. Moreover, the variability of 68Ga-FAPI-04 uptake in normal organs was measured to provide a basis for analyzing its biological distribution, interpreting auxiliary images, determining the reliability of image quantification, and monitoring treatment. Six patients (3 subjects without tumors and 3 lung cancer patients) separately underwent 68Ga-FAPI-04 and 2-[18F]FDG PET/CT imaging within 1 week. The biodistribution and internal radiation dosimetry were reported and compared with data previously obtained from Caucasian patients. Moreover, the mean SUV (standardized uptake value) was normalized to body mass or to lean body mass (SUL), and the coefficients of variation (CVs) were calculated and compared for each volume of interest. The average whole-body effective dose was calculated to be 1.27E-02 mSv/MBq, which was comparable with previously reported results of 68Ga-FAPI-04 probes. Furthermore, the SUVmean was slightly higher than the SULmean in most organs; however, the CV of the SULmean for most organs was higher than that of the SUVmean at later time points. In the liver, the CV of the SUVmean was lower (12.7%) than that of the SULmean and was similar to the CV for corresponding 2-[18F]FDG PET/CT value (11.8%). In addition, 68Ga-FAPI-04 PET/CT showed good efficacy for diagnosing lung cancer patients in this study. A comparison of the radiation dosimetry obtained before from a Caucasian population demonstrated no clinically significant differences between these two populations after 68Ga-FAPI-04 injection. The variability in most organs was slightly lower for SUVmean than for SULmean, suggesting that SUVmean may be the preferable parameter for quantifying images obtained with 68Ga-FAPI-04. In addition, 68Ga-FAPI-04 PET/CT imaging is expected to be a promising tool for diagnosing lung cancer.

scholarly journals Evaluation of strategies towards harmonization of FDG PET/CT studies in multicentre trials: comparison of scanner validation phantoms and data analysis procedures

2013 ◽  
Vol 40 (10) ◽  
pp. 1507-1515 ◽  
Author(s):  
Nikolaos E. Makris ◽  
Marc C. Huisman ◽  
Paul E. Kinahan ◽  
Adriaan A. Lammertsma ◽  
Ronald Boellaard
Keyword(s):  
Data Analysis ◽  
Fdg Pet ◽  
Pet Ct ◽  
Multicentre Trials ◽  
Fdg Pet Ct ◽  
Ct Studies
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