Differential expression pattern of estrogen receptors, aromatase, and sulfotransferase in breast cancer tissue and corresponding lymph node metastases

Tumor Biology ◽  
2010 ◽  
Vol 32 (3) ◽  
pp. 501-508 ◽  
Author(s):  
Daphne Gschwantler-Kaulich ◽  
Anneliese Fink-Retter ◽  
Klaus Czerwenka ◽  
Gernot Hudelist ◽  
Axel Kaulich ◽  
...  
Author(s):  
Mariusz Koda ◽  
Andrzej Lenczewski ◽  
Mariola Sulkowska ◽  
Luiza Kanczuga-Koda ◽  
Andrzej Wincewicz ◽  
...  

1977 ◽  
Vol 63 (1) ◽  
pp. 97-107 ◽  
Author(s):  
José Garcia Puche ◽  
Silvana Canevari ◽  
Giuseppe Fossati ◽  
Giuseppe Della Porta ◽  
Paolo Vezzoni

The conditions for a 51Cr release assay on cell lines derived from human solid tumors were determined by using a rabbit antihuman antiserum with human AB serum as source of complement. By this assay 38 sera collected before and after surgery from 19 breast cancer patients and 28 sera from 12 melanoma patients and 16 healthy donors were tested on 3 lines derived from breast cancer tissue and 1 line derived from normal breast tissue. Ten of the breast cancer patients had lymph node metastases and 9 did not. Positive reactions were obtained from 4 breast cancer patients, all with lymph node metastases, and from 1 healthy donor. In a second experiment, 58 coded sera belonging to 4 different groups of cancer and non-cancer individuals were assayed on a colonic cancer line (HT-29), and 33 and 20 of them were also tested on a melanoma line (MeWo) and on a breast cancer line (MaCa 13), respectively. Positive responses were few, and were more frequently observed among transfused than non-transfused patients.


2020 ◽  
Author(s):  
Shahan Mamoor

Metastasis to the brain is a complication of breast cancer (1, 2) with limited treatment options (3). We mined published microarray data (4, 5) to discover genes associated with brain metastases in patients with metastatic breast cancer. We identified significant differential expression of the gene encoding the vascular endothelial growth factor A, VEGFA, in both the brain metastases and lymph node metastases of patients with breast cancer as compared to primary tumors of the breast. VEGF-A, a molecule described to possess the ability to disrupt the blood-brain barrier (6), may be relevant to the underlying biology by which tumor cells of the breast spread to the lymph nodes and to the brain.


BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Juan Zhao ◽  
Chunxiu Hu ◽  
Cheng Wang ◽  
Wei Yu ◽  
Yinglu Guo ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document