Breast cancer sentinel lymph node mapping using near-infrared guided indocyanine green in comparison with blue dye

Pelvic and para-aortic lymphadenectomy is routinely performed in early ovarian cancer to define the stage of the disease. However, it may be associated with increased blood loss, operative time, and length of hospitalization. The sentinel lymph node technique has been shown to be safe and feasible in vulvar, uterine, and cervical cancer. Data detailing feasibility and outcomes of sentinel lymph node mapping in ovarian cancer are scarce.To summarize the studies evaluating the feasibility of sentinel lymph node detection from the ovary, examining the technique and detection rate.A systematic search of the literature was performed using PubMed and Embase from June 1991 to February 2019. Studies describing the sentinel lymph node technique and lymphatic drainage of the ovaries were incorporated in this review. Ten articles were selected, comprising a total of 145 patients. A variety of agents were used, but the primary markers were technetium-99m radiocolloid (Tc-99m), patent blue, or indocyanine green, and the most common injection site was the ovarian ligaments.The overall sentinel lymph node detection rate was 90.3%.We propose a standardized technique sentinel lymph node mapping in ovarian cancer, using indocyanine green, or Tc-99m and blue dye as alternative tracers, injected in both the suspensory and the infundibulopelvic ligament of the ovary.

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Isosulfan Blue Dye Reactions During Sentinel Lymph Node Mapping for Breast Cancer

Anesthesia & Analgesia ◽

10.1097/00000539-200208000-00026 ◽

2002 ◽

Vol 95 (2) ◽

pp. 385-388 ◽

Cited By ~ 17

Author(s):

Leslie L. Montgomery ◽

Alisa C. Thorne ◽

Kimberly J. Van Zee ◽

Jane Fey ◽

Alexandra S. Heerdt ◽

...

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Sentinel Lymph Node Mapping ◽

Blue Dye ◽

Isosulfan Blue ◽

Lymph Node Mapping ◽

Isosulfan Blue Dye

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Identification of Sentinel Lymph Node in Breast Cancer with three Tracers (Radiocolloid, Methylene blue, and Indocyanine Green). (Case Report)

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2020.4491 ◽

2020 ◽

Vol 8 (C) ◽

pp. 94-98

Author(s):

Goran Borislav Kondov ◽

Viktor Gruev ◽

Sinisha Stojanovski ◽

Magdalena Bogdanovska-Todorovska ◽

Risto Colanceski ◽

...

Keyword(s):

Breast Cancer ◽

Methylene Blue ◽

Case Report ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Indocyanine Green ◽

Near Infrared ◽

Early Stage ◽

Fluorescent Imaging ◽

Blue Dye

BACKGROUND: Sentinel lymph node (SNL) biopsy in breast cancer for the determination of axillary status is standard procedures in surgical treatment of early-stage breast cancer. The identification of the SNL is usually performed by radiocolloid injection or/and injection of methylene blue due. The use of indocyanine green (ICG) dye, which is fluorescent dye, which movement in breast and axillar pit, can be followed with special cameras which detect near infrared specatar of light. CASE REPORT: In this paper, we present case report of patient with breast cancer, where we perform SNL detection with three methods: Use of radiocolloid which we trace with static gamma camera, and intraoperatively with hand held gamma probe, methylene blue dye which movement we followed by eye contact and using indocyanine green which movement was followed by specially constructed multispectral camera, which can detect near-infrared fluorescence that is emitted by ICG and methyline blue, respectively. CONCLUSION: Fluorescent imaging with ICG is a sensitive, valuable, and safe method for SNL biopsy. Finding new agents that would identify the SNL, especially if they are not radioactive would be an important step in wider application of this method.

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