Combined analysis of copy number alterations by single-nucleotide polymorphism array and MYC status in non-metastatic breast cancer patients: comparison according to the circulating tumor cell status

Tumor Biology ◽  
2014 ◽  
Vol 36 (2) ◽  
pp. 711-718
Author(s):  
R. Nadal ◽  
M. Salido ◽  
L. Nonell ◽  
M. Rodríguez-Rivera ◽  
E. Puigdecanet ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Nucleotide Polymorphism ◽  
Copy Number ◽  
Single Nucleotide Polymorphism Array ◽  
Metastatic Breast ◽  
Circulating Tumor Cell ◽  
Copy Number Alterations ◽  
Breast Cancer Patients ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide

scholarly journals Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array

2021 ◽  
Author(s):  
Yoshihiro Shioi ◽  
Mitsumasa Osakabe ◽  
Naoki Yanagawa ◽  
Hiroyuki Nitta ◽  
Akira Sasaki ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Biliary Tract ◽  
Copy Number ◽  
Single Nucleotide Polymorphism Array ◽  
Biliary Tract Carcinoma ◽  
Copy Number Alterations ◽  
Nucleotide Polymorphism ◽  
Duct Carcinoma ◽  
Single Nucleotide ◽  
Somatic Copy Number Alterations

Aim: Biliary tract carcinoma (BTC), including gall bladder carcinoma (GBC) and biliary duct carcinoma (BDC), has a poor prognosis. Comprehensive genomic profiling has important roles in evaluation of the carcinogenesis of BTC. Materials & methods: We examined somatic copy number alterations (SCNAs) using a single nucleotide polymorphism array system to analyze 36 BTC samples (11 GBCs and 25 BDCs). Results: In hierarchical cluster analysis, two clusters were identified (subgroup 1 with low SCNAs and subgroup 2 with high SCNAs). GBC was predominant in subgroup 1, whereas BDC was predominant in subgroup 2, suggesting that GBC and BDC had different genetic backgrounds in terms of SCNAs. Conclusion: These findings could be helpful for establishing the molecular carcinogenesis of BTCs.

Detection of Copy Number Variations in Breast Cancer Samples Using Single-nucleotide Polymorphism-targeted Massively Multiplexed PCR

2014 ◽  
Vol 207 (6) ◽  
pp. 287
Author(s):  
Joshua E. Babiarz ◽  
Bernhard G. Zimmermann ◽  
Tudor Constantin ◽  
Ryan Swenerton ◽  
Eser Kirkizlar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Nucleotide Polymorphism ◽  
Copy Number ◽  
Copy Number Variations ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Multiplexed Pcr
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