Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53

Tumor Biology ◽  
2015 ◽  
Vol 37 (5) ◽  
pp. 6007-6016 ◽  
Author(s):  
Guoqiang Ai ◽  
Rakesh Dachineni ◽  
D. Ramesh Kumar ◽  
Srinivasan Marimuthu ◽  
Lloyd F. Alfonso ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Mutant P53 ◽  
Colon Cancer Cells ◽  
Wild Type

scholarly journals The Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53 but Not Mutant p53 to Topotecan Treatment

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45058 ◽  
Author(s):  
Dan-Dan Li ◽  
Ting Sun ◽  
Xiao-Qi Wu ◽  
Shu-Peng Chen ◽  
Rong Deng ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Mutant P53 ◽  
Colon Cancer Cells ◽  
Wild Type ◽  
Wild Type P53

Abstract 3699: Aspirin acetylates wild type and mutant p53 in colon cancer cells: Identification of aspirin acetylated sites on recombinant p53

2016 ◽  
Author(s):  
Guoqiang Ai ◽  
Rakesh Dachineni ◽  
Ramesh D. Kumar ◽  
Srinivasan Marimuthu ◽  
Lloyd F. Alfonso ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Mutant P53 ◽  
Colon Cancer Cells ◽  
Wild Type

scholarly journals Limonene and BEZ 235 inhibits growth of COLO-320 and HCT-116 colon cancer cells

2016 ◽  
Vol 8 (3) ◽  
pp. 89 ◽  
Author(s):  
Raja Ratna Reddy Yakkanti ◽  
P Chandra Sekhar ◽  
K Bharath Nandhan Reddy ◽  
S Ramamoorthy ◽  
S Ranga Suresh ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Wild Type ◽  
Anticancer Effects ◽  
Clonogenic Potential ◽  
Hct 116 ◽  
Cancer Types ◽  
Hct 116 Cells ◽  
Preclinical And Clinical Studies

<p>D-Limonene is a dietary monoterpene with significant anticancer activity against many cancer types in preclinical and clinical studies. The study is designed to investigate synergistic anticancer effects of limonene and BEZ235 combination in COLO-320 and HCT-116 colon cancer cells. Cells were treated with both the drugs alone and in combination and the effects on cell viability; cell migration and clonogenic potential were examined. Results show that both drugs exhibited dose and time dependant cytotoxicity on the cell lines tested. CompuSyn analysis of the drug combination effects revealed the strong synergistic interaction of the combination. Our results also indicate that COLO-320 cells were more sensitive for anticancer effects of the drugs than HCT-116 cells. The presence of Ras and PI3K mutations in HCT-116 cells could possibly be one of the main reasons for the observed outcome as compared to the wild type expressions of them in COLO-320 cells.</p>

scholarly journals Dysregulated Phosphorylation of p53, Autophagy and Stemness Attributes the Mutant p53 Harboring Colon Cancer Cells Impaired Sensitivity to Oxaliplatin

2020 ◽  
Vol 10 ◽  
Author(s):  
Lubna Therachiyil ◽  
Javeria Haroon ◽  
Fairooz Sahir ◽  
Kodappully S. Siveen ◽  
Shahab Uddin ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Mutant P53 ◽  
Colon Cancer Cells

scholarly journals JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagy

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Xinbing Sui ◽  
Na Kong ◽  
Xian Wang ◽  
Yong Fang ◽  
Xiaotong Hu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Mutant P53 ◽  
Colon Cancer Cells

Ceragenin CSA-13 induces cell cycle arrest and antiproliferative effects in wild-type and p53 null mutant HCT116 colon cancer cells

2013 ◽  
Vol 24 (8) ◽  
pp. 826-834 ◽  
Author(s):  
Kengo Kuroda ◽  
Tomokazu Fukuda ◽  
Kazuhiko Okumura ◽  
Hiroshi Yoneyama ◽  
Hiroshi Isogai ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Cycle Arrest ◽  
Cancer Cells ◽  
Null Mutant ◽  
Colon Cancer Cells ◽  
Wild Type ◽  
Antiproliferative Effects ◽  
Cycle Arrest

scholarly journals Protoporphyrin IX Interacts with Wild-type p53 Proteinin Vitroand Induces Cell Death of Human Colon Cancer Cells in a p53-dependent and -independent Manner

2006 ◽  
Vol 282 (4) ◽  
pp. 2466-2472 ◽  
Author(s):  
Joanna Zawacka-Pankau ◽  
Natalia Issaeva ◽  
Shakil Hossain ◽  
Aladdin Pramanik ◽  
Galina Selivanova ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Protoporphyrin Ix ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Wild Type ◽  
Human Colon Cancer ◽  
Independent Manner ◽  
Human Colon Cancer Cells
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