Prediction of single nucleotide polymorphisms (SNPs) in apolipoprotein E gene and their possible associations with a deleterious effect on the structure and functional properties: an in silico approach

2018 ◽  
Vol 7 (1) ◽  
Author(s):  
Noor AlHuda Ali A. H. Saeed ◽  
Israa Hussein Hamzah ◽  
Alaa Naseer Mohammed Ali ◽  
Abdulwahab Ali Abuderman
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Apolipoprotein E ◽  
Functional Properties ◽  
In Silico ◽  
Deleterious Effect ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
E Gene ◽  
Apolipoprotein E Gene

Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene as risk factors for Alzheimer’s disease

2018 ◽  
Vol 684 ◽  
pp. 86-90 ◽  
Author(s):  
Jolanta Bratosiewicz-Wasik ◽  
Pawel P. Liberski ◽  
Beata Peplonska ◽  
Maria Styczynska ◽  
Joanna Smolen-Dzirba ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Single Nucleotide Polymorphisms ◽  
Apolipoprotein E ◽  
Regulatory Region ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
E Gene ◽  
Apolipoprotein E Gene

scholarly journals Evidence for Non-additive Influence of Single Nucleotide Polymorphisms within the Apolipoprotein E Gene

2004 ◽  
Vol 68 (6) ◽  
pp. 521-535 ◽  
Author(s):  
S. C. Hamon ◽  
J. H. Stengard ◽  
A. G. Clark ◽  
V. Salomaa ◽  
E. Boerwinkle ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Apolipoprotein E ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
E Gene ◽  
Apolipoprotein E Gene ◽  
Additive Influence

scholarly journals Apolipoprotein E–Promoter Single-Nucleotide Polymorphisms Affect the Phenotype of Primary Open-Angle Glaucoma and Demonstrate Interaction with the Myocilin Gene

2002 ◽  
Vol 70 (6) ◽  
pp. 1575-1581 ◽  
Author(s):  
Bruno Copin ◽  
Antoine P. Brézin ◽  
Françoise Valtot ◽  
Jean-Claude Dascotte ◽  
Alain Béchetoille ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Apolipoprotein E ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Nucleotide Polymorphisms ◽  
Open Angle ◽  
Single Nucleotide

scholarly journals Genetic Variants in the Promoter Region of miR-10b and the Risk of Breast Cancer

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Jiaping Chen ◽  
Yue Jiang ◽  
Jing Zhou ◽  
Sijun Liu ◽  
Yayun Gu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Single Nucleotide Polymorphisms ◽  
In Silico ◽  
Promoter Region ◽  
Cancer Susceptibility ◽  
Chinese Women ◽  
Close Association ◽  
Breast Cancer Susceptibility ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Variants in microRNA genes may affect their expression by interfering with the microRNA maturation process and may substantially contribute to the risk of breast cancer. Recent studies have identified miR-10b as an interesting candidate because of its close association with the metastatic behavior of breast cancer. However, the roles of miR-10b-related single nucleotide polymorphisms in breast cancer susceptibility remain unclear. This case-control study evaluated the associations between variants in the upstream transcription regulation region of miR-10b and the risk of breast cancer among Chinese women. Seven potentially functional SNPs were investigated using genotyping assays. The potential biological functions of the identified positive SNPs were further evaluated using in silico databases. We found that rs4078756, which was located at the promoter region of miR-10b, was significantly associated with breast cancer risk (rs4078756 AG/GG versus AA, adjusted odds ratio: 1.17, 95% confidence interval: 1.02–1.35). The other six single nucleotide polymorphisms exhibited negative associations. Based on the in silico prediction, rs4078756 potentially regulated miR-10b expression through promoter activation or repression. These findings indicate that a potentially functional SNP (rs4078756) in the promoter region of miR-10b may contribute to breast cancer susceptibility among Chinese women.

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