Warfarin prophylaxis in migraine without aura but not in primary exercise headache

Objective This study aims to investigate pregnancy and perinatal outcomes in women with tension-type headache, migraine without aura and migraine with aura by comparing them to women without any headache disorders. Study design Prospective cohort study including singleton pregnancies attending the first trimester aneuploidy screening at the University Hospital of Modena, in Northern Italy, between June 2018 and December 2019. Results A total of 515 consecutive women were included and headache disorders were reported in 43.5% of them (224/515). Tension-type headache was diagnosed in 24.3% of the cases, while 14% suffered from migraine without aura and 5.2% from migraine with aura. Birthweight was significantly lower in women affected by migraine with aura respective to other groups, and a significantly higher rate of small for gestational age infants was found in tension-type headache (10.4%) and in migraine with aura (24.9%) groups respective to the others (p < 0.001). Moreover, the admission to the neonatal intensive care unit was significantly higher in all the headache groups (p = 0.012). Multivariate analysis showed that women presenting tension-type headache (OR 4.19, p = 0.004), migraine with aura (OR 5.37, p = 0.02), a uterine artery pulsatility index >90th centile (OR 3.66, p = 0.01), low multiple of the median (MoM) of Pregnancy-associated plasma protein-A (PAPP-A) (OR 0.48, p = 0.05) and high MoM of Inhibin-A (OR 3.24, p = 0.03) at first trimester, are independently associated with the delivery of small for gestational age infants when compared to women without headache disorders. Conclusion Migraine with aura and tension type headache expose women to an increased risk of delivering small for gestational age infants, in association with some utero-placenta markers evaluated at first trimester. These women with headache disorders have an additional indication to undergo first trimester aneuploidy screening and would possibly benefit from specific interventions.

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Over-expression of IL-6 coding gene in the peripheral blood of migraine with aura patients

Human Antibodies ◽

10.3233/hab-210442 ◽

2021 ◽

pp. 1-5

Author(s):

Mahdi Ramezani ◽

Alireza Komaki ◽

Mohammad Mahdi Eftekharian ◽

Mehrdokht Mazdeh ◽

Soudeh Ghafouri-Fard

Keyword(s):

Migraine With Aura ◽

Peripheral Blood ◽

Healthy Subjects ◽

Migraine Without Aura ◽

P Value ◽

Healthy Controls ◽

Over Expression ◽

Significant Difference ◽

Male Patients ◽

Years Lived With Disability

Migraine is a common disorder which is placed among the top ten reasons of years lived with disability. Cytokines are among the molecules that contribute in the pathophysiology of migraine. In the current study, we evaluated expression levels of IL-6 coding gene in the peripheral blood of 120 migraine patients (54 migraine without aura and 66 migraine with aura patients) and 40 healthy subjects. No significant difference was detected in expression of IL-6 between total migraine patients and healthy controls (Posterior beta = 0.253, P value = 0.199). The interaction effect between gender and group was significant (Posterior beta =-1.274, P value = 0.011), therefore, we conducted subgroup analysis within gender group. Such analysis revealed that while expression of this gene is not different between male patients and male controls (Posterior beta =-0.371, P value > 0.999), it was significantly over-expressed in female patients compared with female controls (Posterior beta = 0.86, P= 0.002). Expression of IL-6 was significantly higher in patients with aura compared with controls (Posterior beta = 0.63, adjusted P value = 0.019). However, expression of this cytokine coding gene was not different between patients without aura and healthy subjects (Posterior beta = 0.193, adjusted P value = 0.281). Therefore, IL-6 might be involved in the pathophysiology of migraine among females and migraine with aura among both sexes.

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Supersaturation of VEP in Migraine without Aura Patients Treated with Topiramate: An Anatomo-Functional Biomarker of the Disease

Journal of Clinical Medicine ◽

10.3390/jcm10040769 ◽

2021 ◽

Vol 10 (4) ◽

pp. 769

Author(s):

Ciro De Luca ◽

Sara Gori ◽

Sonia Mazzucchi ◽

Elisa Dini ◽

Martina Cafalli ◽

...

Keyword(s):

Visual Cortex ◽

Cortical Neurons ◽

Migraine Without Aura ◽

Inverse Correlation ◽

Primary Headache ◽

Contrast Gain ◽

High Prevalence ◽

Functional Pathway ◽

Inhibitory Signaling ◽

Potential Use

Migraine is a primary headache with high prevalence among the general population, characterized by functional hypersensitivity to both exogenous and endogenous stimuli particularly affecting the nociceptive system. The hyperresponsivity of cortical neurons could be due to a disequilibrium in the excitatory/inhibitory signaling. This study aimed to investigate the anatomo-functional pathway from the retina to the primary visual cortex using visual evoked potentials (VEP). Contrast gain protocol was used in 15 patients diagnosed with migraine without aura (at baseline and after 3 months of topiramate therapy) and 13 controls. A saturation (S) index was assessed to monitor the response of VEP’s amplitude to contrast gain. Non-linear nor monotone growth of VEP (S < 0.95) was defined as supersaturation. A greater percentage of migraine patients (53%) relative to controls (7%) showed this characteristic. A strong inverse correlation was found between the S index and the number of days separating the registration of VEP from the next migraine attack. Moreover, allodynia measured through the Allodynia Symptoms Check-list (ASC-12) correlates with the S index both at baseline and after 3 months of topiramate treatment. Other clinical characteristics were not related to supersaturation. Topiramate therapy, although effective, did not influence electrophysiological parameters suggesting a non-intracortical nor retinal origin of the supersaturation (with possible involvement of relay cells from the lateral geniculate nucleus). In conclusion, the elaboration of visual stimuli and visual cortex activity is different in migraine patients compared to controls. More data are necessary to confirm the potential use of the S index as a biomarker for the migraine cycle (association with the pain-phase) and cortical sensitization (allodynia).

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A Case of Migraine Without Aura That Was Successfully Treated With an Herbal Medicine

The Journal of Alternative and Complementary Medicine ◽

10.1089/acm.2013.0147 ◽

2013 ◽

Vol 19 (12) ◽

pp. 970-972 ◽

Cited By ~ 2

Author(s):

Shun Takaku ◽

Eiichi Osono ◽

Hideki Kuribayashi ◽

Chizuno Takaku ◽

Naoki Hirama ◽

...

Keyword(s):

Herbal Medicine ◽

Migraine Without Aura

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Migraine With Aura and Migraine Without Aura: One Entity, Two, Or More?

Cephalalgia ◽

10.1046/j.1468-2982.1995.015003182.x ◽

1995 ◽

Vol 15 (3) ◽

pp. 182-182 ◽

Cited By ~ 4

Author(s):

G Tietjen

Keyword(s):

Migraine With Aura ◽

Migraine Without Aura

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Personality Traits in Childhood and Adolescent Headache

Cephalalgia ◽

10.1046/j.1468-2982.2001.00144.x ◽

2001 ◽

Vol 21 (1) ◽

pp. 53-60 ◽

Cited By ~ 28

Author(s):

G Lanzi ◽

CA Zambrino ◽

O Ferrari-Ginevra ◽

C Termine ◽

S D'Arrigo ◽

...

Keyword(s):

Clinical Study ◽

Personality Traits ◽

Test Anxiety ◽

Migraine Without Aura ◽

Tension Type Headache ◽

Personality Characteristics ◽

Anxiety And Depression ◽

Sociodemographic Data ◽

Type Headache ◽

Adolescent Headache

We evaluate personality traits, anxiety and depression in a population of paediatric and adolescent patients, correlating personality characteristics with headache and sociodemographic variables. The clinical features of headache include specific personality traits. We report a clinical study of 57 patients (age 8–18 years), divided up as follows: 12 migraine with aura, 29 migraine without aura and 16 tension-type headache. One of Cattel's tests was administered to every patient; the Children's Depression Inventory test was administered to 53 patients and the Test Anxiety Inventory test to 43 subjects. The scores obtained by every patient in each test were correlated with the characteristics of headache and with sociodemographic data. We found that patients affected by idiopathic headache share some personality traits, mainly emotional rigidity and tendency to repress anger and aggression. These traits do not seem to be correlated with sociodemographic data and the duration of headache: we considered these as characteristic of migrainous patients.

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Somatosensory gating is altered and associated with migraine chronification: A magnetoencephalographic study

Cephalalgia ◽

10.1177/0333102417712718 ◽

2017 ◽

Vol 38 (4) ◽

pp. 744-753 ◽

Cited By ~ 12

Author(s):

Fu-Jung Hsiao ◽

Shuu-Jiun Wang ◽

Yung-Yang Lin ◽

Jong-Ling Fuh ◽

Yu-Chieh Ko ◽

...

Keyword(s):

Chronic Migraine ◽

Migraine Without Aura ◽

Headache Frequency ◽

Sensory Modulation ◽

Brain Excitability ◽

Paired Stimuli ◽

Somatosensory Cortices ◽

First Response ◽

Electrical Stimuli ◽

Somatosensory Gating

Background Brain excitability is changed in migraine but not fully characterized yet. This study explored if somatosensory gating is altered in migraine and linked to migraine chronification. Methods Paired electrical stimuli were delivered to the left index fingers of 21 patients with migraine without aura (MO), 22 patients with chronic migraine (CM), and 36 controls. The first and second responses to the paired stimuli were obtained from the contralateral primary (cSI), contralateral secondary (cSII) and ipsilateral secondary (iSII) somatosensory cortices to compute the gating ratios (second vs. first response strengths). Results The first and second cSI responses and gating ratios differed in all groups ( p < 0.05); the responses were typically smaller in the MO and CM groups. The cSI gating ratio increased as a continuum across controls (0.73 ± 0.04, p < 0.001), MO (0.83 ± 0.04) to CM (0.97 ± 0.06) and was higher in CM vs. controls ( p < 0.001). When MO and CM were combined, cSI gating ratio was associated with headache frequency (r = 0.418, p = 0.005). Paired responses and gating ratios of cSII and iSII did not differ among the groups. Conclusions Somatosensory gating is altered in migraine and associated with headache chronification. Further studies must clarify if this abnormal sensory modulation is a true gating deficit independent of low preexcitation level.

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Genetic TPH2 variants and the susceptibility for migraine: association of a TPH2 haplotype with migraine without aura

Journal of Neural Transmission ◽

10.1007/s00702-010-0468-6 ◽

2010 ◽

Vol 117 (11) ◽

pp. 1253-1260 ◽

Cited By ~ 7

Author(s):

Alexander Jung ◽

Andreas Huge ◽

Gregor Kuhlenbäumer ◽

Steffi Kempt ◽

Tanja Seehafer ◽

...

Keyword(s):

Migraine Without Aura

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