scholarly journals Poly(lactic acid)/poly(lactic-co-glycolic acid) particulate carriers for pulmonary drug delivery

2019 ◽  
Vol 49 (4) ◽  
pp. 427-442 ◽  
Author(s):  
Fakhrossadat Emami ◽  
Seyed Jamaleddin Mostafavi Yazdi ◽  
Dong Hee Na
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Glycolic Acid ◽  
Pulmonary Drug Delivery ◽  
Poly Lactic Acid ◽  
Particulate Carriers

Biodegradable poly(lactide-co-glycolide-co-ε-caprolactone) block copolymers – evaluation as drug carriers for a localized and sustained delivery system

2015 ◽  
Vol 3 (41) ◽  
pp. 8143-8153 ◽  
Author(s):  
Ji Hoon Park ◽  
Hwi Ju Kang ◽  
Doo Yeon Kwon ◽  
Bo Keun Lee ◽  
Bong Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Delivery Systems ◽  
Glycolic Acid ◽  
Drug Carrier ◽  
Drug Carriers ◽  
Poly Lactic Acid ◽  
Sustained Delivery ◽  
System P ◽  
Biodegradable Poly

To develop an appropriate drug carrier for drug delivery systems, we prepared random poly(lactide-co-glycolide-co-ε-caprolactone) (PLGC) copolymers in comparison to commercial poly(lactic acid-co-glycolic acid) (PLGA) grades.

scholarly journals Mechanical Properties and Bioactivity of Poly(Lactic Acid) Composites Containing Poly(Glycolic Acid) Fiber and Hydroxyapatite Particles

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 249
Author(s):  
Han-Seung Ko ◽  
Sangwoon Lee ◽  
Doyoung Lee ◽  
Jae Young Jho
Keyword(s):  
Mechanical Properties ◽  
Lactic Acid ◽  
Flexural Strength ◽  
Interfacial Adhesion ◽  
Glycolic Acid ◽  
Compact Bone ◽  
Poly Lactic Acid ◽  
Coupling Reactions ◽  
The Poor ◽  
Human Compact Bone

To enhance the mechanical strength and bioactivity of poly(lactic acid) (PLA) to the level that can be used as a material for spinal implants, poly(glycolic acid) (PGA) fibers and hydroxyapatite (HA) were introduced as fillers to PLA composites. To improve the poor interface between HA and PLA, HA was grafted by PLA to form HA-g-PLA through coupling reactions, and mixed with PLA. The size of the HA particles in the PLA matrix was observed to be reduced from several micrometers to sub-micrometer by grafting PLA onto HA. The tensile and flexural strength of PLA/HA-g-PLA composites were increased compared with those of PLA/HA, apparently due to the better dispersion of HA and stronger interfacial adhesion between the HA and PLA matrix. We also examined the effects of the length and frequency of grafted PLA chains on the tensile strength of the composites. By the addition of unidirectionally aligned PGA fibers, the flexural strength of the composites was greatly improved to a level comparable with human compact bone. In the bioactivity tests, the growth of apatite on the surface was fastest and most uniform in the PLA/PGA fiber/HA-g-PLA composite.

scholarly journals Poly(lactic acid-glycolic acid) nanoparticles markedly improve immunological protection provided by peptide P10 against murine paracoccidioidomycosis

2010 ◽  
Vol 159 (5) ◽  
pp. 1126-1132 ◽  
Author(s):  
André C Amaral ◽  
Alexandre F Marques ◽  
Julián E Muñoz ◽  
Anamélia L Bocca ◽  
Andreza R Simioni ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Glycolic Acid ◽  
Poly Lactic Acid ◽  
Immunological Protection
Sign in / Sign up

Export Citation Format

Share Document