Differential degradation rates in vivo and in vitro of biocompatible poly(lactic acid) and poly(glycolic acid) homo- and co-polymers for a polymeric drug-delivery microchip

2004 ◽  
Vol 15 (10) ◽  
pp. 1281-1304 ◽  
Author(s):  
Amy C.R. Grayson ◽  
Gabriela Voskerician ◽  
Aaron Lynn ◽  
James M. Anderson ◽  
Michael J. Cima ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Glycolic Acid ◽  
Poly Lactic Acid ◽  
Polymeric Drug Delivery ◽  
Degradation Rates ◽  
Polymeric Drug ◽  
Differential Degradation

scholarly journals In Vitro and In Vivo Antitumor Activity of a Novel pH-Activated Polymeric Drug Delivery System for Doxorubicin

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e44116 ◽  
Author(s):  
Menglei Huan ◽  
Bangle Zhang ◽  
Zenghui Teng ◽  
Han Cui ◽  
Jieping Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antitumor Activity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymeric Drug Delivery ◽  
In Vivo Antitumor Activity ◽  
Polymeric Drug

scholarly journals In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 29
Author(s):  
Seung Kyun Yoon ◽  
Jin Ho Yang ◽  
Hyun Tae Lim ◽  
Young-Wook Chang ◽  
Muhammad Ayyoob ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Animal Experiments ◽  
Polymeric Materials ◽  
Polyglycolic Acid ◽  
Poly Lactic Acid ◽  
Skin Sensitization ◽  
Spinal Fixation ◽  
In Vivo Degradation

Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Every specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials.

In vitro and in vivo release of insulin from poly(lactic acid) microbeads and pellets

1986 ◽  
Vol 4 (1) ◽  
pp. 47-62 ◽  
Author(s):  
A.K. Kwong ◽  
S. Chou ◽  
A.M. Sun ◽  
M.V. Sefton ◽  
M.F.A. Goosen
Keyword(s):  
Lactic Acid ◽  
Poly Lactic Acid ◽  
In Vivo Release

CO2-switchable drug release from magneto-polymeric nanohybrids

2015 ◽  
Vol 6 (12) ◽  
pp. 2319-2326 ◽  
Author(s):  
Hailong Che ◽  
Meng Huo ◽  
Liao Peng ◽  
Qiquan Ye ◽  
Jun Guo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymeric Drug Delivery ◽  
Polymeric Drug

A CO2-responsive well-defined magneto-polymeric drug delivery system has been developed. A dosage release of doxorubicin (DOX) in vitro in a time-controllable manner can be easily executed with alternate CO2/N2 treatment by these smart nanocarriers.

scholarly journals DEGRADASI POLIBLEND POLI(ASAMLAKTAT-KO-ASAMGLIKOLAT) DENGAN POLI(ε-KAPROLAKTON) SECARA IN VITRO

2015 ◽  
Vol 2 (2) ◽  
pp. 174
Author(s):  
Tetty Kemala ◽  
Achmad Sjahriza ◽  
Hendra Adijuwana ◽  
Mardiana Hardianti
Keyword(s):  
Lactic Acid ◽  
Polylactic Acid ◽  
Intrinsic Viscosity ◽  
Phosphate Buffer ◽  
Glycolic Acid ◽  
Incubation Temperature ◽  
Human Life ◽  
Polyglycolic Acid ◽  
Poly Lactic Acid

 ABSTRACT  Polymer has many applications in human life, one of them is in the field of health. Polymer synthetics like polylactic acid (PLA), polyglycolic acid (PGA), poly(ε-caprolactone) (PCL), and poly(lactic acid-co-glycolic acid) (PLGA) were kind of polyesters that is many used in field   of health. Many researchers have already made research about degradation of PLA, PGA, PCL, and PLGA. However, there is no one doing research about degradation of combination between this two polymers, one of them is polyblend of  PLGA and PCL. Polyblend were made of four compositions, that were PLGA(90:10):PCL 3:1, PLGA(75:25):PCL 3:1, PLGA(90:10):PCL 5:1, and PLGA(75:25):PCL 5:1. Degradation was carried out for eight weeks by using phosphate buffer pH 7.4 and incubation temperature of 37°C. Degradation of the polymer was observed by mass remained, and intrinsic viscosity. The result showed that composition PLGA(75:25):PCL 5:1 was the fastest in degradation compared to other compositions. It was showed by the decrease in mass until 89.06% and the change in intrinsic viscosity until 20.13%. Keywords: PLGA, PCL   

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