Biodegradable poly(lactide-co-glycolide-co-ε-caprolactone) block copolymers – evaluation as drug carriers for a localized and sustained delivery system

API-ILs were encapsulated into biocompatible PLLA. The morphology and crystallinity of the resulting membranes can be tuned by varying the IL nature and content leading to controlled release.

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Resealed Erythrocytes as Drug Carriers and Its Therapeutic Applications

Pharmaceutical Sciences ◽

10.4018/978-1-5225-1762-7.ch018 ◽

2017 ◽

pp. 459-485

Author(s):

Prabhakar Singh ◽

Sudhakar Singh ◽

Rajesh Kumar Kesharwani

Keyword(s):

Drug Delivery ◽

Blood Cells ◽

Drug Delivery Systems ◽

Release Kinetics ◽

Drug Carrier ◽

Drug Loading ◽

Drug Carriers ◽

Delivery Systems ◽

The Body ◽

Body Ideal

In this pharma innovative world, there are more than 30 drug delivery systems. Today's due to lacking the target specificity, the present scenario about drug delivery is emphasizing towards targeted drug delivery systems. Erythrocytes are the most common type of blood cells travel thousands of miles from wide to narrow pathways to deliver oxygen, drugs and nutrient during their lifetime. Red blood cells have strong and targeted potential carrier capabilities for varieties of drugs. Drug-loaded carrier erythrocytes or resealed erythrocytes are promising for various passive and active targeting. Resealed erythrocyte have advantage over several drug carrier models like biocompatibility, biodegradability without toxic products, inert intracellular environment, entrapping potential for a variety of chemicals, protection of the organism against toxic effects of the drug, able to circulate throughout the body, ideal zero-order drug-release kinetics, no undesired immune response against encapsulated drug etc. Resealed erythrocytes are rapidly taken up by macrophages of the Reticuloendothelial System (RES) of the liver, lung, and spleen of the body and hence drugs also. Resealed erythrocytes method of drugs delivery is secure and effective for drugs targeting specially for a longer period of time. This chapter will explain the different method of drug loading for resealed erythrocytes, their characterization, and applications in various therapies and associated health benefits.

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Resealed Erythrocytes as Drug Carriers and Its Therapeutic Applications

Advances in Medical Technologies and Clinical Practice - Recent Advances in Drug Delivery Technology ◽

10.4018/978-1-5225-0754-3.ch012 ◽

2016 ◽

pp. 340-366

Author(s):

Prabhakar Singh ◽

Sudhakar Singh ◽

Rajesh Kumar Kesharwani

Keyword(s):

Drug Delivery ◽

Blood Cells ◽

Drug Delivery Systems ◽

Release Kinetics ◽

Drug Carrier ◽

Drug Loading ◽

Drug Carriers ◽

Delivery Systems ◽

The Body ◽

Body Ideal

In this pharma innovative world, there are more than 30 drug delivery systems. Today's due to lacking the target specificity, the present scenario about drug delivery is emphasizing towards targeted drug delivery systems. Erythrocytes are the most common type of blood cells travel thousands of miles from wide to narrow pathways to deliver oxygen, drugs and nutrient during their lifetime. Red blood cells have strong and targeted potential carrier capabilities for varieties of drugs. Drug-loaded carrier erythrocytes or resealed erythrocytes are promising for various passive and active targeting. Resealed erythrocyte have advantage over several drug carrier models like biocompatibility, biodegradability without toxic products, inert intracellular environment, entrapping potential for a variety of chemicals, protection of the organism against toxic effects of the drug, able to circulate throughout the body, ideal zero-order drug-release kinetics, no undesired immune response against encapsulated drug etc. Resealed erythrocytes are rapidly taken up by macrophages of the Reticuloendothelial System (RES) of the liver, lung, and spleen of the body and hence drugs also. Resealed erythrocytes method of drugs delivery is secure and effective for drugs targeting specially for a longer period of time. This chapter will explain the different method of drug loading for resealed erythrocytes, their characterization, and applications in various therapies and associated health benefits.

Download Full-text