Preparation of hydroxyapatite/poly(lactic acid) hybrid microparticles for local drug delivery

IOP Conference Series Materials Science and Engineering ◽

10.1088/1757-899x/47/1/012007 ◽

2013 ◽

Vol 47 ◽

pp. 012007 ◽

Author(s):

D Loca ◽

J Locs ◽

L Berzina-Cimdina

Keyword(s):

Drug Delivery ◽

Lactic Acid ◽

Local Drug Delivery ◽

Poly Lactic Acid

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Enhanced drug delivery, mechanical properties and antimicrobial activities in poly(lactic acid) nanofiber with mesoporous Fe3O4-COOH nanoparticles

Colloids and Surfaces A Physicochemical and Engineering Aspects ◽

10.1016/j.colsurfa.2018.09.012 ◽

2018 ◽

Vol 559 ◽

pp. 104-114 ◽

Author(s):

Chao Han ◽

Ning Cai ◽

Vincent Chan ◽

Mingming Liu ◽

Xiaojuan Feng ◽

...

Keyword(s):

Mechanical Properties ◽

Drug Delivery ◽

Lactic Acid ◽

Antimicrobial Activities ◽

Poly Lactic Acid

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In vitro and in vivo evaluation of clarithromycin/poly(lactic acid) microspheres for intramuscular drug delivery

Journal of Controlled Release ◽

10.1016/0168-3659(93)90190-g ◽

1993 ◽

Vol 26 (3) ◽

pp. 229-238 ◽

Author(s):

P.K. Gupta ◽

H. Johnson ◽

C. Allexon

Keyword(s):

Drug Delivery ◽

Lactic Acid ◽

Poly Lactic Acid ◽

In Vivo Evaluation

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Scaffolds for drug delivery, part I: electrospun porous poly(lactic acid) and poly(lactic acid)/poly(ethylene oxide) hybrid scaffolds

Journal of Materials Science ◽

10.1007/s10853-010-5161-5 ◽

2010 ◽

Vol 46 (9) ◽

pp. 2874-2881 ◽

Author(s):

Sara Honarbakhsh ◽

Behnam Pourdeyhimi

Keyword(s):

Drug Delivery ◽

Lactic Acid ◽

Ethylene Oxide ◽

Poly Lactic Acid ◽

Poly Ethylene Oxide ◽

Poly Ethylene ◽

Hybrid Scaffolds ◽

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Effects of shell thickness of hollow poly(lactic acid) nanoparticles on sustained drug delivery for pharmacological treatment of glaucoma

Acta Biomaterialia ◽

10.1016/j.actbio.2020.04.055 ◽

2020 ◽

Vol 111 ◽

pp. 302-315 ◽

Author(s):

Duc Dung Nguyen ◽

Li-Jyuan Luo ◽

Jui-Yang Lai

Keyword(s):

Drug Delivery ◽

Lactic Acid ◽

Pharmacological Treatment ◽

Shell Thickness ◽

Poly Lactic Acid ◽

Sustained Drug Delivery

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Effect of the configuration of poly(lactic acid) and content of poly(oxyethylene) blocks to the structure and functional properties of poly(lactic acid)‐ block ‐poly(oxirane)‐based nanofibrous electrospun polyester–ether–urethanes used as potential drug‐delivery system

Journal of Biomedical Materials Research Part B Applied Biomaterials ◽

10.1002/jbm.b.34331 ◽

2019 ◽

Vol 107 (7) ◽

pp. 2378-2387 ◽

Author(s):

Alena Pavelková ◽

Pavel Kucharczyk ◽

Zdenka Capáková ◽

Petra Peer ◽

Martina Pummerová ◽

...

Keyword(s):

Drug Delivery ◽

Lactic Acid ◽

Drug Delivery System ◽

Functional Properties ◽

Delivery System ◽

Poly Lactic Acid ◽

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Optimal construction and pharmacokinetic study of CZ48-loaded poly (lactic acid) microbubbles for controlled drug delivery

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2019.02.047 ◽

2019 ◽

Vol 178 ◽

pp. 269-275 ◽

Author(s):

Si-yang Li ◽

Sheng-lei Guo

Keyword(s):

Drug Delivery ◽

Lactic Acid ◽

Pharmacokinetic Study ◽

Controlled Drug Delivery ◽

Poly Lactic Acid ◽

Optimal Construction

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Evaluation of poly(lactic acid) as a biodegradable drug delivery system for parenteral administration

International Journal of Pharmaceutics ◽

10.1016/0378-5173(86)90081-5 ◽

1986 ◽

Vol 30 (2-3) ◽

pp. 215-220 ◽

Author(s):

Alan Smith ◽

lan M. Hunneyball

Keyword(s):

Drug Delivery ◽

Lactic Acid ◽

Drug Delivery System ◽

Delivery System ◽

Parenteral Administration ◽

Poly Lactic Acid

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Physicochemical Evaluation of Nanoparticles Assembled from Poly(lactic acid)−Poly(ethylene glycol) (PLA−PEG) Block Copolymers as Drug Delivery Vehicles

Langmuir ◽

10.1021/la001226i ◽

2001 ◽

Vol 17 (11) ◽

pp. 3168-3174 ◽

Author(s):

T. Riley ◽

S. Stolnik ◽

C. R. Heald ◽

C. D. Xiong ◽

M. C. Garnett ◽

...

Keyword(s):

Drug Delivery ◽

Lactic Acid ◽

Block Copolymers ◽

Ethylene Glycol ◽

Poly Lactic Acid ◽

Poly Ethylene Glycol ◽

Drug Delivery Vehicles ◽

Physicochemical Evaluation ◽

Delivery Vehicles ◽

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Drug delivery systems based on pharmaceutically active ionic liquids and biocompatible poly(lactic acid)

Journal of Materials Chemistry B ◽

10.1039/c4tb00264d ◽

2014 ◽

Vol 2 (20) ◽

pp. 3133-3141 ◽

Author(s):

Claire Jouannin ◽

Corine Tourné-Péteilh ◽

Vincent Darcos ◽

Tahmer Sharkawi ◽

Jean-Marie Devoisselle ◽

...

Keyword(s):

Drug Delivery ◽

Ionic Liquids ◽

Lactic Acid ◽

Controlled Release ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Poly Lactic Acid

API-ILs were encapsulated into biocompatible PLLA. The morphology and crystallinity of the resulting membranes can be tuned by varying the IL nature and content leading to controlled release.

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Surface Engineered Poly(lactic acid) (PLA) Microspheres by Chemical Treatment for Drug Delivery System

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.594-595.214 ◽

2013 ◽

Vol 594-595 ◽

pp. 214-218 ◽

Author(s):

C.Y. Tham ◽

Zuratul Ain Abdul Hamid ◽

Z.A. Ahmad ◽

H. Ismail

Keyword(s):

Drug Delivery ◽

Contact Angle ◽

Lactic Acid ◽

Drug Delivery System ◽

Water Contact Angle ◽

Delivery System ◽

Alkaline Solution ◽

Alkaline Hydrolysis ◽

Poly Lactic Acid ◽

Poly (lactic acid) (PLA) is well known for their biodegradability and bioresorbable properties and these properties made them suitable in drug delivery system as drug carriers. PLA is relatively hydrophobic and lack of cell-recognition group to interact with biologically active molecules which reduce the surface compatibility of microspheres. In this project, alkaline hydrolysis was used to induce hydrophilic functional group on the microspheres surface. Alkaline solution at 0.01M and 0.1M was used to modify microspheres surfaces. The engineered surfaces were evaluated using Scanning Electron Microscopy and Water Contact Angle. 0.1M alkaline solution hydrolyzed microspheres at higher extends as compared to 0.01M, where partial microspheres disintegrated and porous structure was revealed. The water contact angle of PLA films shows decreased from 65 ̊ to range 42 47 ̊ after alkaline hydrolysis.

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