Net benefit regarding the risk for death with sodium-glucose co-transporter-2 inhibitors across the hallmark cardiovascular and renal outcome trials; are there any drug differences?

2022 ◽  
Author(s):  
Dimitrios Patoulias ◽  
Christodoulos Papadopoulos ◽  
Aristi Boulmpou ◽  
Konstantinos Stavropoulos ◽  
Michael Doumas
Keyword(s):  
Renal Outcome ◽  
Net Benefit

MODEL UNTUK UJI KUALITAS SISTEM INFORMASI UJIAN NASIONAL BERBASIS KOMPUTER TINGKAT SMA & MA

2018 ◽  
Vol 14 (2) ◽  
pp. 187
Author(s):  
Irwan Agus Sobari ◽  
Fajar Akbar ◽  
Robi Aziz Zauma ◽  
Amin Nur Rais
Keyword(s):  
Net Benefit

UNBK (Ujian Nasional Berbasis Komputer) adalah aplikasi ujian nasional yang berkembang yang telah mengklaim perhatian dan ketertarikan peneliti perkembangan ilmu komputer di dunia pendidikan. Salah satu perkembangan terbaru yang paling diterima di UNBK adalah kemanfaatan nya. Kami mengusulkan sebuah model model sukses DeLone & McLean IS untuk menganalisis kualitas UNBK pada kemanfaatan penggunanya. Pendekatan empiris didasarkan pada kuesioner survei online terhadap siswa SMA & MA, hasil feedback yang diterima sebanyak 74 individu. Hasilnya mengungkapkan bahwa Kualitas Informasi, Kualitias Sistem dan Kualitas pelayanan adalah preseden penting dari kepuasan pengguna, dan pentingnya kepuasan pengguna akan menghasilkan net benefit yang cukup signifikan. Memahami pentingnya konteks UNBK pada Net Benefit bagi pengguna berguna untuk memberikan wawasan baru kepada instansi terkait untuk menerapkan strategi untuk mempertahankan pengguna atau bahkan menarik pengadopsi potensial. penelitian ini memberikan implikasi teoritis dan praktis dari temuan penelitian.

549-P: Renal Outcome of Patients with Type 2 Diabetes Exhibiting Normoalbuminuric Renal Insufficiency

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 549-P
Author(s):  
YUI NISHIWAKI ◽  
KO HANAI ◽  
TETSUYA BABAZONO
Keyword(s):  
Type 2 Diabetes ◽  
Renal Insufficiency ◽  
Renal Outcome

Nitrogen Requirement of Potato for Eastern Indo-Gangatic Plain of India

2020 ◽  
Vol 7 (03) ◽  
Author(s):  
S. K. YADAV ◽  
R. K. SINGH ◽  
V. K. DUA ◽  
S SINGH ◽  
SARALA YADAV ◽  
...  
Keyword(s):  
Tuber Yield ◽  
Potato Crop ◽  
Block Design ◽  
Nitrogen Level ◽  
Cost Ratio ◽  
Research Station ◽  
Net Benefit ◽  
Marketable Tuber ◽  
Benefit Cost Ratio ◽  
Significant Difference

A field experiment was carried out during 2015-16 and 2016-17 at ICAR-Central Potato Research Station, Patna, Bihar, in randomized block design with four replications with objective to quantity the optimum requirement of nitrogen to potato crop. Significantly the highest plant height was recorded with nitrogen level of 300 kg/ha. Distributions of the smallest size of tuber yield of potato were decreasing with increasing the level of nitrogen. There was about 26.0% more yield of the smallest size tuber of potato was recorded with zero nitrogen as compare to the highest level of nitrogen i.e. 300 kg/ha. Increasing the nitrogen over the level of 150 to 225 kg per hectare, increasing the yield of tuber gradually slower rate than nitrogen level from 0 to 150 kg/ha. Total and marketable tuber yield of potato were increasing significantly with increasing level of nitrogen up to 150 kg/ha. There was no significant difference in marketable tuber yield was found for nitrogen level between 150 and 225 kg/ha. Highest (1.66) net benefit cost ratio was also recorded with level of nitrogen @ 150 kg/ha in potato. Hence, application of nitrogen @ 150 kg/ha was found statistically and economically more beneficial for potato cultivation in Eastern Indo-Gangatic plain of India.

scholarly journals Reproductive Performance and Partial Budget Analysis of a Prostaglandin or a Modified Ovsyn3ch Protocol in Autumn Calving Dairy Herds

Animals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1031
Author(s):  
George Lindley ◽  
Jim Willshire ◽  
Steven Van Winden
Keyword(s):  
Relative Effectiveness ◽  
Dairy Herds ◽  
Net Benefit ◽  
Start Date ◽  
Budget Analysis ◽  
Partial Budget ◽  
Holstein Friesian ◽  
Input Variables ◽  
Input Uncertainties ◽  
Relative Profitability

In autumn calving dairy herds, treatment of cattle not observed in estrus prior to the breeding season is common. Routinely, a single prostaglandin or a modified Ovsynch (MOFT) protocol are used—without evidence of their relative effectiveness. This study compares the effects on conception, associated timing, and profitability of administering cows with prostaglandin or MOFT treatment. A hundred and ninety-two Holstein-Friesian cows from three herds without an observed estrus within 28-days before mating start date were randomly treated with d-cloprostenol (PGOD) or an 8-day MOFT protocol. The association of treatment and calving-breeding start-date interval (CBSI) on the risk of conception were investigated. Partial budget, sensitivity analysis, and Monte Carlo simulation was used to assess economic performance, identify critical input variables, and explore the effects of input uncertainties on model output. There was a significant association between MOFT treatment and conception during 21 and 84 days after mating start date, compared to PGOD. MOFT treatment was associated with a mean net benefit of £58.21 (sd £19.42) and £27.29 (sd £17.75) per cow for herds with a fixed or variable dry-off date, respectively. The relative profitability of an MOFT protocol is dependent on its effects on barren rate and herd dry-off strategy.

scholarly journals SAT0211 RENAL INJURY IN SYSTEMIC LUPUS ERYTHEMATOSUS CHARACTERIZED BY THROMBOTIC MICROANGIOPATHY

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1048.1-1048
Author(s):  
W. Hu
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Nephritis ◽  
Renal Biopsy ◽  
Lupus Erythematosus ◽  
Thrombotic Microangiopathy ◽  
Renal Injury ◽  
Renal Outcome ◽  
Pathological Examination ◽  
Systemic Lupus ◽  
Tubulointerstitial Lesions

Background:Classical lupus nephritis (LN) is characterized by glomerular immune complex(IC) deposition with glomerular proliferation, basement membrane destruction and cell infiltration. Non-IC mediated renal injury with thrombotic microangiopathy (TMA) was also reported in patients with systemic lupus erythematosus (SLE-renal TMA), but most studies were reported in patients with both LN and renal TMA.Objectives:In this study, clinical features and outcomes of SLE-renal TMA in absence of obvious IC in SLE patients were analyzed.Methods:Patients with glomerular TMA and/or vascular TMA in the absence of obvious subendothelial or epithelial immune deposits were screened out from 2332 biopsied in SLE patients who underwent first renal biopsy from January 2005 to August 2016. Their clinical, histological features and outcomes were retrospectively analyzed.Results:In 2332 renal biopsies obtained from SLE patients, 257 (11.0%) showed renal TMA, of which 237 showed both renal TMA and LN, and 20 biopsies had only renal TMA (SLE-renal TMA). There were 2 males and 18 females with an average age of (25 ± 10) years. The median course of SLE and LN were 3.0(1.0, 6.0) and 0.8(0.5, 1.9) months. All 20 patients deserved acute kidney injury, of which 11 (55%) needed renal replacement therapy (RRT) and 12 (60%) were nephrotic syndrome. Blood system involvement was found in all cases, including 13 cases (65.0%) with TMA triad (microvascular hemolytic anemia, thrombocytopenia and elevated lactate dehydrogenase).Pathological examination showed that 17 cases (85.0%) had both glomerular TMA and vascular TMA. Immunofluorescence and electron microscopy showed that 8 cases (40%) had no IC deposition in glomerulus and 12 cases (60%) had only IC deposition in mesangium. Acute tubulointerstitial lesions in patients requiring RRT were more serious than those no needing for RRT((43.6±24.9) %vs(21.7±20.1) %,P=0.047). The fusion range of foot process was positively correlated with proteinuria (r2= 0.347,P=0.006).All patients received high-dose methylprednisolone pulse therapy. Four patients received plasma exchange and three patients received gamma globulin, respectively. Eleven patients requiring RRT all stop RRT in a median time of 16.0 (9.0, 30.0) days. During a median follow-up of 58.0 (36.0, 92.3) months, complete remission (CR) was obtained in 15 cases, partial remission in 4 cases and no remission in 1 case. Six cases (30%) relapsed. No case died or progressed to end stage renal disease.Conclusion:Renal injury characterized by TMA is not uncommon in SLE renal biopsy cases. The clinical manifestation is special and the renal injury is serious. The renal outcome is good by intensive immunosuppressive therapy. It should be considered as a unique type of renal injury in SLE.References:[1]Moake JL. Thrombotic microangiopathies. N Engl J Med. 2002. 347(8): 589-600.[2]Anders HJ, Weening JJ. Kidney disease in lupus is not always ‘lupus nephritis’. Arthritis Res Ther. 2013. 15(2): 108.[3]Song D, Wu LH, Wang FM, et al. The spectrum of renal thrombotic microangiopathy in lupus nephritis. Arthritis Res Ther. 2013. 15(1): R12.[4]Hu WX, Liu ZZ, Chen HP, Zhang HT, Li LS, Liu ZH. Clinical characteristics and prognosis of diffuse proliferative lupus nephritis with thrombotic microangiopathy. Lupus. 2010. 19(14): 1591-8.[5]Tomov S, Lazarchick J, Self SE, Bruner ET, Budisavljevic MN. Kidney-limited thrombotic microangiopathy in patients with SLE treated with romiplostim. Lupus. 2013. 22(5): 504-9.[6]Li C, Yap D, Chan G, et al. Clinical Outcomes and Clinico-pathological Correlations in Lupus Nephritis with Kidney Biopsy Showing Thrombotic Microangiopathy. J Rheumatol. 2019 .[7]Chen MH, Chen MH, Chen WS, et al. Thrombotic microangiopathy in systemic lupus erythematosus: a cohort study in North Taiwan. Rheumatology (Oxford). 2011. 50(4): 768-75.[8]Park MH, AUID- Oho, Caselman N, Ulmer S, Weitz IC, AUID- Oho. Complement-mediated thrombotic microangiopathy associated with lupus nephritis. Blood Adv. 2018. 2(16): 2090-2094.Disclosure of Interests:None declared

scholarly journals Glomerular function in relation to fine airborne particulate matter in a representative population sample

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ying-Mei Feng ◽  
Lutgarde Thijs ◽  
Zhen-Yu Zhang ◽  
Esmée M. Bijnens ◽  
Wen-Yi Yang ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Population Sample ◽  
Airborne Particulate Matter ◽  
Blood Stream ◽  
Renal Outcome ◽  
Cross Sectional ◽  
Cholesterol Ratio ◽  
Median Serum ◽  
Renal Responses

AbstractFrom 1990 until 2017, global air-pollution related mortality increased by 40%. Few studies addressed the renal responses to ultrafine particulate [≤ 2.5 µm (PM2.5)], including black carbon (BC), which penetrate into the blood stream. In a Flemish population study, glomerular filtration estimated from serum creatinine (eGFR) and the urinary albumin-to-creatinine ratio were measured in 2005–2009 in 820 participants (women, 50.7%; age, 51.1 years) with follow-up of 523 after 4.7 years (median). Serum creatinine, eGFR, chronic kidney disease (eGFR < 60 mL/min/1.73 m2) and microalbuminuria (> 3.5/> 2.5 mg per mmol creatinine in women/men) were correlated in individual participants via their residential address with PM2.5 [median 13.1 (range 0.3–2.9) μg/m3] and BC [1.1 (0.3–18) μg/m3], using mixed models accounting for address clusters. Cross-sectional and longitudinally, no renal outcome was associated with PM2.5 or BC in models adjusted for sex and baseline or time varying covariables, including age, blood pressure, heart rate, body mass index, plasma glucose, the total-to-HDL serum cholesterol ratio, alcohol intake, smoking, physical activity, socioeconomic class, and antihypertensive treatment. The subject-level geocorrelations of eGFR change with to BC and PM2.5 were 0.13 and 0.02, respectively (P ≥ 0.68). In conclusion, in a population with moderate exposure, renal function was unrelated to ultrafine particulate.

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