scholarly journals Calcium Channel Blockers in Secondary Cardiovascular Prevention and Risk of Acute Events: Real-World Evidence from Nested Case–Control Studies on Italian Hypertensive Elderly

2017 ◽  
Vol 37 (12) ◽  
pp. 1165-1174 ◽  
Author(s):  
Alessandra Bettiol ◽  
◽  
Ersilia Lucenteforte ◽  
Alfredo Vannacci ◽  
Niccolò Lombardi ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Real World ◽  
Calcium Channel Blockers ◽  
Cardiovascular Prevention ◽  
Case Control ◽  
Channel Blockers ◽  
Case Control Studies ◽  
Real World Evidence ◽  
Nested Case Control ◽  
Secondary Cardiovascular Prevention

Case—Control Studies of Cardiovascular Medications as Risk Factors for Clinically Diagnosed Depressive Disorders in a Hospitalized Population

1996 ◽  
Vol 41 (7) ◽  
pp. 469-476 ◽  
Author(s):  
Scott B Patten ◽  
Jeanne VA Williams ◽  
Edgar J Love
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Ace Inhibitors ◽  
Depressive Disorders ◽  
Case Control ◽  
Control Group ◽  
Channel Blockers ◽  
Discharge Diagnosis ◽  
Case Control Studies ◽  
Β Blockers

Objective: Certain medications used in cardiovascular therapeutics may contribute to the etiology of substance-induced mood disorders. These medications include digoxin, angiotensin converting enzyme (ACE) inhibitors, β- blockers, and calcium channel blockers. The objective of this study was to evaluate associations between these drugs and clinical diagnoses of depressive disorders in a population of hospitalized patients. Method: Two case–control studies were conducted. For each study, subjects were selected from a health records data base maintained at the Calgary General Hospital. Selection of subjects in the first study was restricted to those receiving a discharge diagnosis of congestive heart failure and in the second study to subjects receiving a discharge diagnosis of hypertension. In each of these 2 studies, a single case group was selected along with 2 control groups: a psychiatric control group consisting of subjects receiving a psychiatric diagnosis other than a depressive disorder and a nonpsychiatric control group receiving no psychiatric diagnoses. Drug exposures and other variables were recorded from a chart review. Results: Exposures to digoxin, β- blockers, and calcium channel blockers were not associated with depressive diagnoses. An association was observed, however, for ACE inhibitors. An elevated odds ratio (OR) was observed in each case-control study and was stronger infernale subjects and subjects over the age of 65. Conclusions: This is the first reported epidemiological evidence of an association between ACE inhibitors and depressive disorders. The design of this study does not permit a determination of whether the observed association was causal. Additional studies are needed.

Calcium Channel Blockers and the Risk for Lung Cancer: A Population-Based Nested Case-Control Study

2018 ◽  
Vol 53 (5) ◽  
pp. 445-452 ◽  
Author(s):  
Victoria Rotshild ◽  
Laurent Azoulay ◽  
Ilan Feldhamer ◽  
Amichai Perlman ◽  
Mendel Glazer ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Channel Blockers ◽  
Nested Case Control ◽  
Control Study

Background: It has been suggested that calcium channel blockers (CCBs) may increase the risk of lung cancer; however, current evidence is conflicting and limited. Objective: Investigate the associations between CCB use and lung cancer. Methods: We conducted a population-based nested case-control study. A cohort was formed of patients prescribed their first antihypertensive agent from 2000 to 2014. CCB exposure information was obtained by identification of all prescriptions dispensed during study follow-up. Cases were patients newly diagnosed with lung cancer during follow-up. Each case was matched with 10 controls by age, sex, calendar year of cohort entry, and duration of follow-up. Multivariate conditional logistic regression was used to estimate odds ratios (ORs) with 95% CIs of lung cancer associated with ever use of CCBs. Results: During a median follow-up of 6.2 years, we identified 4174 cases of lung cancer. Ever use of CCBs was associated with an increased risk of lung cancer (adjusted OR = 1.13; 95% CI = 1.06-1.21), when compared with the use of other antihypertensive drugs. A duration-response relation was observed, with the ORs gradually increasing with longer cumulative duration of CCB use (<5 years: OR = 1.12, 95% CI = 1.04-1.20; 5-10 years: OR = 1.22, 95% CI = 1.07-1.40; >10 years: OR = 1.33, 95% CI = 0.90-1.96; P trend < 0.001). Conclusion and Relevance: The results of this large population-based study indicate that the use of CCBs is associated with a modest but significant increase in the risk of lung cancer. This association appeared to increase with longer duration of use.

Calcium channel blockers and myocardial infarction: a case-control study in a Japanese hospital

2002 ◽  
Vol 11 (6) ◽  
pp. 487-492 ◽  
Author(s):  
Yoshiharu Ohyama ◽  
Kazuhiro Funao ◽  
Eri Kawabe ◽  
Doubun Hayashi ◽  
Tsutomu Yamazaki ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Case Control Study ◽  
Case Control ◽  
Channel Blockers ◽  
Control Study

scholarly journals Chronic Eczematous Eruptions of the Elderly Are Associated with Chronic Exposure to Calcium Channel Blockers: Results from a Case–Control Study

2007 ◽  
Vol 127 (12) ◽  
pp. 2766-2771 ◽  
Author(s):  
Pascal Joly ◽  
Cloe Benoit-Corven ◽  
Sophie Baricault ◽  
Audrey Lambert ◽  
Marie F. Hellot ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Chronic Exposure ◽  
Case Control Study ◽  
The Elderly ◽  
Case Control ◽  
Channel Blockers ◽  
Control Study
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