The effect of heterogeneous surface charges on mixing in a combined electroosmotic/pressure-driven micromixer

Author(s):  
A. Farahinia ◽  
J. Jamaati ◽  
H. Niazmand ◽  
Wenjun Zhang
Micromachines ◽  
2019 ◽  
Vol 10 (8) ◽  
pp. 498 ◽  
Author(s):  
Aminul Islam Khan ◽  
Prashanta Dutta

Time-periodic electroosmotic flow (EOF) with heterogeneous surface charges on channel walls can potentially be used to mix species or reagent molecules in microfluidic devices. Although significant research efforts have been placed to understand different aspects of EOF, its role in the mixing process is still poorly understood, especially for non-homogeneous surface charge cases. In this work, dynamic aspects of EOF in a cylindrical capillary are analyzed for heterogeneous surface charges. Closed form analytical solutions for time-periodic EOF are obtained by solving the Navier–Stokes equation. An analytical expression of induced pressure is also obtained from the velocity field solution. The results show that several vortices can be formed inside the microchannel with sinusoidal surface charge distribution. These vortices change their pattern and direction as the electric field change its strength and direction with time. In addition, the structure and strength of the vorticity depend on the frequency of the external electric field and the size of the channel. As the electric field frequency or channel diameter increases, vortices are shifted towards the channel surface and the perturbed flow region becomes smaller, which is not desired for effective mixing. Moreover, the number of vorticities depends on the periodicity of the surface charge.


2003 ◽  
Vol 773 ◽  
Author(s):  
James D. Kubicek ◽  
Stephanie Brelsford ◽  
Philip R. LeDuc

AbstractMechanical stimulation of single cells has been shown to affect cellular behavior from the molecular scale to ultimate cell fate including apoptosis and proliferation. In this, the ability to control the spatiotemporal application of force on cells through their extracellular matrix connections is critical to understand the cellular response of mechanotransduction. Here, we develop and utilize a novel pressure-driven equibiaxial cell stretching device (PECS) combined with an elastomeric material to control specifically the mechanical stimulation on single cells. Cells were cultured on silicone membranes coated with molecular matrices and then a uniform pressure was introduced to the opposite surface of the membrane to stretch single cells equibiaxially. This allowed us to apply mechanical deformation to investigate the complex nature of cell shape and structure. These results will enhance our knowledge of cellular and molecular function as well as provide insights into fields including biomechanics, tissue engineering, and drug discovery.


2013 ◽  
Vol 23 (2) ◽  
pp. 165-191
Author(s):  
Mohamed F. El-Sayed ◽  
M. H. M. Moussa ◽  
Ahmed A. A. Hassan ◽  
N. M. Hafez

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