Association of the MC4R rs17782313 polymorphism with plasma ghrelin, leptin, IL6 and TNFα concentrations, food intake and eating behaviors in morbidly obese women

Author(s):  
Fernanda Cristina Carvalho Mattos Magno ◽  
Helena Chrispim Guaraná ◽  
Ana Carolina Proença da Fonseca ◽  
Aline Pereira Pedrosa ◽  
Verônica Marques Zembrzuski ◽  
...  
2019 ◽  
Vol 11 (4) ◽  
pp. 350-359
Author(s):  
Jacqueline M. Wallace ◽  
Joeleita P. Agard ◽  
Graham W. Horgan

AbstractPlacental weight is a valuable indicator of its function, predicting both pregnancy outcome and lifelong health. Population-based centile charts of weight-for-gestational-age and parity are useful for identifying extremes of placental weight but fail to consider maternal size. To address this deficit, a multiple regression model was fitted to derive coefficients for predicting normal placental weight using records from healthy pregnancies of nulliparous/multiparous women of differing height and weight (n = 107,170 deliveries, 37–43 weeks gestation). The difference between actual and predicted placental weight generated a z-score/individual centile for the entire cohort including women with pregnancy complications (n = 121,591). The association between maternal BMI and placental weight extremes defined by the new customised versus population-based standard was investigated by logistic regression, as was the association between low placental weight and pregnancy complications. Underweight women had a greater risk of low placental weight [<10thcentile, OR 1.84 (95% CI 1.66, 2.05)] and obese women had a greater risk of high placental weight [>90th centile, OR 1.98 (95% CI 1.88, 2.10)] using a population standard. After customisation, the risk of high placental weight in obese/morbidly obese women was attenuated [OR 1.17 (95% CI 1.09, 1.25)]/no longer significant, while their risk of low placental weight was 59%–129% higher (P < 0.001). The customised placental weight standard was more closely associated with stillbirth, hypertensive disease, placental abruption and neonatal death than the population standard. Our customised placental weight standard reveals higher risk of relative placental growth restriction leading to lower than expected birthweights in obese women, and a stronger association between low placental weight and pregnancy complications generally. Further, it provides an alternative tool for defining placental weight extremes with implications for the placental programming of chronic disease.


2014 ◽  
Vol 144 (12) ◽  
pp. 2018-2026 ◽  
Author(s):  
Ruth W Kimokoti ◽  
Suzanne E Judd ◽  
James M Shikany ◽  
PK Newby

2008 ◽  
Vol 90 ◽  
pp. S129
Author(s):  
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D. Rochester ◽  
A. Jain ◽  
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K. Gibbs ◽  
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2006 ◽  
Vol 107 (Supplement) ◽  
pp. 5S-6S
Author(s):  
Lindsey E. Baredziak ◽  
Amy Sparks ◽  
Jill Blaine ◽  
Bradley VanVoorhis ◽  
Anuja Dokras

Diabetologia ◽  
2010 ◽  
Vol 53 (6) ◽  
pp. 1210-1216 ◽  
Author(s):  
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C. Hernández ◽  
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...  

Metabolism ◽  
2000 ◽  
Vol 49 (5) ◽  
pp. 607-610 ◽  
Author(s):  
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A. Nardi ◽  
P Grösser

2008 ◽  
Vol 18 (8) ◽  
pp. 1000-1006 ◽  
Author(s):  
José I. Botella-Carretero ◽  
Manuel Luque-Ramírez ◽  
Francisco Álvarez-Blasco ◽  
Roberto Peromingo ◽  
José L. San Millán ◽  
...  

2012 ◽  
Vol 120 (6) ◽  
pp. 1338-1344
Author(s):  
Jennifer M. Park ◽  
Anthony O. Odibo ◽  
Anthony L. Shanks ◽  
Methodius G. Tuuli ◽  
Kimberly A. Roehl ◽  
...  

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