Potential role of fibroblast growth factor 21 in the deterioration of bone quality in impaired glucose tolerance

2020 ◽  
Author(s):  
D. T. W. Lui ◽  
C. H. Lee ◽  
V. W. K. Chau ◽  
C. H. Y. Fong ◽  
K. M. Y. Yeung ◽  
...  
Keyword(s):  
Growth Factor ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Fibroblast Growth Factor ◽  
Bone Quality ◽  
Potential Role ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth

Role of Fibroblast growth factor 21 (FGF-21) as a prognostic marker for fetal and maternal complications in patients with gestational diabetes mellitus

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohamed Reda Halawa ◽  
Magdy Hassan Kolaib ◽  
Salah Hussein El-Halawany ◽  
Dina Ahmed Marwan ◽  
Ola Mohamed Mostafa Shaheen
Keyword(s):  
Diabetes Mellitus ◽  
Growth Factor ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Fibroblast Growth Factor ◽  
Prognostic Marker ◽  
Diagnostic Marker ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth

Abstract Background Gestational diabetes mellitus (GDM) defined as glucose intolerance with onset or first diagnosis during pregnancy. While GDM usually resolves following delivery, it can have long-lasting health consequences, including increased risk for type 2 diabetes (T2DM) and cardiovascular disease (CVD) in the mother, and future obesity, CVD, T2DM, and/or GDM in the child. This contributes to a vicious intergenerational cycle of obesity and diabetes that impacts the health of the population as a whole. Fibroblast growth factor 21 (FGF21) is a hormone that is expressed predominantly in the liver, but also in other metabolically active tissues such as pancreas, skeletal muscle and adipose tissue. An elevated FGF21 level is also an independent predictor of T2DM. GDM and T2DM are proposed to have similar underlying pathophysiologies, raising the question of whether a similar relationship exists between FGF21 and GDM as it does with T2DM. Objectives assess the role of Fibroblast growth factor 21 (FGF-21) as a prognostic marker for maternal and fetal complications in patients with gestational diabetes mellitus (GDM). Patients and Methods A case control study that was conducted on 50 patients diagnosed with Gestational Diabetes Mellitus and 50 control subjects at Diabetes and Obstetrics outpatient clinic and inpatient ward at Ain Shams university hospitals in the period between December 2018 and July 2019. Patients diagnosed with gestational diabetes mellitus (GDM) at 24-28 weeks of gestation were included in this study. Results FGF 21 levels varied significantly with blood sugar values where higher levels of FGF 21 levels were found in patients with GDM with study results showing that FGF 21 can be used as a diagnostic marker for GDM at levels above 121 pg/ml with sensitivity 84% and specificity 92%. Conclusion FGF 21 can be used as a diagnostic marker for gestational diabetes. Further studies needed for better correlation between FGF 21 levels during pregnancy and maternal outcome.

The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic target

2014 ◽  
Vol 18 (11) ◽  
pp. 1305-1313 ◽  
Author(s):  
Wen-Yue Liu ◽  
Sha Huang ◽  
Ke-Qing Shi ◽  
Chen-Chen Zhao ◽  
Li-Li Chen ◽  
...  
Keyword(s):  
Liver Disease ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Therapeutic Target ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth
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