The relationship between serum 25‐hydroxyvitamin-D level and sweat function in patients with type 2 diabetes mellitus

Background: Type 2 diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia. Metabolic syndrome (MS) is a complex metabolic disorder like hyperglycemia, obesity, dyslipidemia, and hypertension. Vitamin D controls genes associated with regulation of insulin and renin production. The aim of this study was to analyze the relation between total levels of 25-hydroxyvitamin D [25(OH)D] and the incidence of MS in type 2 DM patients.Methods: This case control study was conducted from October to November 2018 in Dr Moewardi Hospital Surakarta in 84 people with type 2 diabetes mellitus. All subjects were 34-75 years old. The research data were analyzed with a 2x2 test table to determine the odd ratio (OR) of each study variable, then multivariate analysis with logistic regression then continued.Results: The mean total level of 25(OH)D is 18.01 ± 6.10 ng/dl. Bivariate and multivariate OR analysis showed that poor glycemic control with the incidence of MS (OR: 11.154; 95% Cl: 3.933-31.631; p = 0.001); female sex (OR : 1.788; 95% Cl: 0.750-4.261; p = 0.188); age < 50 year (OR: 1.644; 95% Cl: 0.614-4.404; p = 0.321); and total 25(OH)D deficiency (OR: 1.250; 95% Cl: 0.317-2.022; p = 0.637).Conclusion: total 25(OH)D level is not associated with the incidence of MS in the type 2 DM patients. Further study was needed using by healthy group control to explain the role of vitamin D in type 2 DMKeywords: type 2 DM, metabolic syndrome, 25(OH)D

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Multivariate Path Analysis of Serum 25-Hydroxyvitamin D Concentration, Inflammation, and Risk of Type 2 Diabetes Mellitus

Disease Markers ◽

10.1155/2013/497256 ◽

2013 ◽

Vol 35 ◽

pp. 187-193 ◽

Cited By ~ 9

Author(s):

Shaum M. Kabadi ◽

Longjian Liu ◽

Amy H. Auchincloss ◽

Issa F. Zakeri

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Path Analysis ◽

Hemoglobin A1c ◽

Serum Vitamin ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

Background and Aims.Despite growing interest in the protective role that vitamin D may have in health outcomes, little research has examined the mechanisms underlying this role. This study aimed to test two hypotheses: (1) serum 25-hydroxyvitamin D [25(OH)D] is inversely associated with type 2 diabetes mellitus (T2DM) and elevated hemoglobin A1c; (2) these associations are mediated by serum C-reactive protein (CRP).Methods.Participants aged 20 and older in 2001–2006 National Health and Nutrition Examination Surveys (n= 8,655) with measures of serum 25(OH)D, CRP, hemoglobin A1c, and other important covariates were included in the present study. Logistic regression and path analysis methods were applied to test the study hypotheses.Results.Decreased serum 25(OH)D concentration was significantly associated with increased odds of T2DM. In males, an estimated 14.9% of the association between 25(OH)D and hemoglobin A1c was mediated by serum CRP. However, this mediation effect was not observed in females.Conclusion.Using a nationally representative sample, the present study extends previous research and provides new evidence that the effect of decreased serum vitamin D concentration on T2DM may proceed through increased systemic inflammation in males. Longitudinal studies and randomized control trials are needed to confirm the present findings.

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Low Serum 25-Hydroxyvitamin D Levels and the Bidirectional Association Between Depression and Type 2 Diabetes Mellitus in Women—Reply

Archives of Internal Medicine ◽

10.1001/archinternmed.2011.223 ◽

2011 ◽

Vol 171 (11) ◽

pp. 1041

Author(s):

An Pan

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Hydroxyvitamin D ◽

Bidirectional Association ◽

25 Hydroxyvitamin D ◽

Low Serum

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Serum 25-hydroxyvitamin D level and diabetic nephropathy in patients with type 2 diabetes mellitus

International Urology and Nephrology ◽

10.1007/s11255-015-0983-3 ◽

2015 ◽

Vol 47 (6) ◽

pp. 983-989 ◽

Cited By ~ 14

Author(s):

Yan Peng ◽

Liu-juan Li

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetic Nephropathy ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Relationship between Serum 25-Hydroxyvitamin D and Lower Extremity Arterial Disease in Type 2 Diabetes Mellitus Patients and the Analysis of the Intervention of Vitamin D

Journal of Diabetes Research ◽

10.1155/2015/815949 ◽

2015 ◽

Vol 2015 ◽

pp. 1-6 ◽

Cited By ~ 7

Author(s):

Wan Zhou ◽

Shan-Dong Ye

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Type 2 Diabetes Mellitus ◽

Density Lipoprotein ◽

Arterial Disease ◽

Lower Extremity Arterial Disease ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

The aim of this study was to explore the relationship between serum 25-hydroxyvitamin D [25(OH)D] concentrations and lower extremity arterial disease (LEAD) in type 2 diabetes mellitus (T2DM) patients and to investigate the intervention effect of vitamin D. 145 subjects were assigned to a control group (Group NC), T2DM group (Group DM1), and T2DM complicated with LEAD group (Group DM2); then Group DM2 were randomly divided into Group DM3 who received oral hypoglycemic agents and Group DM4 who received oral hypoglycemic drugs and vitamin D3 therapy. Compared to Group NC, 25(OH)D was significantly lower in Group DM2 and marginally lower in Group DM1. In contrast to baseline and Group DM3, 25(OH)D rose while low density lipoprotein (LDL), retinol binding protein 4 (RBP4), and HbA1c significantly lowered in Group DM4. Statistical analysis revealed that 25(OH)D had a negative correlation with RBP4, duration, HbA1c, homeostasis model assessment for insulin resistance (HOMA-IR), and fasting plasma glucose (FPG). LDL, systolic blood pressure (SBP), FPG, and smoking were risk factors of LEAD while high density lipoprotein (HDL) and 25(OH)D were protective ones. Therefore, we deduced that low level of 25(OH)D is significantly associated with the occurrence of T2DM complicated with LEAD.

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