scholarly journals Post-COVID-vaccine autoimmune/inflammatory syndrome in response to adjuvants (ASIA syndrome) manifesting as subacute thyroiditis

2021 ◽  
Author(s):  
L. Das ◽  
S. K. Bhadada ◽  
A. Sood
Keyword(s):  
Subacute Thyroiditis ◽  
Asia Syndrome ◽  
Inflammatory Syndrome

scholarly journals Three Cases of Subacute Thyroiditis Following SARS-CoV-2 Vaccine: Post-vaccination ASIA Syndrome

2021 ◽  
Author(s):  
Burçin Gönül İremli ◽  
Süleyman Nahit Şendur ◽  
Uğur Ünlütürk
Keyword(s):  
Clinical Laboratory ◽  
Previous History ◽  
Subacute Thyroiditis ◽  
Imaging Features ◽  
Upper Respiratory Tract ◽  
Post Vaccination ◽  
Laboratory Test Results ◽  
History Of ◽  
Asia Syndrome ◽  
Inflammatory Syndrome

Abstract Context Autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome) can be seen as a post-vaccination phenomenon that occurs after exposure to adjuvants in vaccines that increase the immune responses. There is very limited data regarding ASIA syndrome following SARS-CoV-2 vaccines. Objectives This work aims to report cases of subacute thyroiditis related to the SARS-CoV-2 vaccine. Methods We describe the clinical, laboratory, and imaging features of three cases of subacute thyroiditis after inactivated SARS-CoV-2 vaccine (CoronaVac®). Three female healthcare workers have applied to our clinic with anterior neck pain and fatigue four to seven days after SARS-CoV-2 vaccination. Two of them were in the breastfeeding period. They were negative for thyroid antibodies, and there was no previous history of thyroid disease or upper respiratory tract infection, or COVID-19. Laboratory test results and imaging findings were consistent with subacute thyroiditis. Results SARS-CoV-2 vaccination can lead to subacute thyroiditis as a phenomenon of ASIA syndrome. Subacute thyroiditis may develop within a few days after the SARS-CoV-2 vaccination. Being in the postpartum period may be a facilitating factor for the development of ASIA syndrome after the SARS-CoV-2 vaccination. Conclusions This is the first report of subacute thyroiditis as a phenomenon of ASIA syndrome after inactivated COVID-19 vaccination. Clinicians should be aware that subacute thyroiditis may develop as a manifestation of ASIA syndrome after the inactive SARS-CoV-2 vaccine.

The autoimmune/inflammatory syndrome induced by adjuvants (ASIA)/Shoenfeld’s syndrome: descriptive analysis of 300 patients from the international ASIA syndrome registry

2017 ◽  
Vol 37 (2) ◽  
pp. 483-493 ◽  
Author(s):  
Abdulla Watad ◽  
Mariana Quaresma ◽  
Nicola Luigi Bragazzi ◽  
Ricard Cervera ◽  
Jan Willem Cohen Tervaert ◽  
...  
Keyword(s):  
Descriptive Analysis ◽  
Asia Syndrome ◽  
Inflammatory Syndrome

scholarly journals Classical Examples of the Concept of the ASIA Syndrome

Biomolecules ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1436
Author(s):  
Vânia Borba ◽  
Anna Malkova ◽  
Natalia Basantsova ◽  
Gilad Halpert ◽  
Laura Andreoli ◽  
...  
Keyword(s):  
Immune System ◽  
Clinical Manifestations ◽  
Breast Implants ◽  
Undifferentiated Connective Tissue Disease ◽  
Ptpn22 Gene ◽  
Silicone Breast Implants ◽  
Immune Mediated ◽  
Asia Syndrome ◽  
Skin Biopsies ◽  
Inflammatory Syndrome

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 by Shoenfeld et al. and encompasses a cluster of related immune mediated diseases, which develop among genetically prone individuals as a result of adjuvant agent exposure. Since the recognition of ASIA syndrome, more than 4400 documented cases have been reported so far, illustrated by heterogeneous clinical manifestations and severity. In this review, five enigmatic conditions, including sarcoidosis, Sjögren’s syndrome, undifferentiated connective tissue disease, silicone implant incompatibility syndrome (SIIS), and immune-related adverse events (irAEs), are defined as classical examples of ASIA. Certainly, these disorders have been described after an adjuvant stimulus (silicone implantation, drugs, infections, metals, vaccines, etc.) among genetically predisposed individuals (mainly the HLA-DRB1 and PTPN22 gene), which induce an hyperstimulation of the immune system resulting in the production of autoantibodies, eventually leading to the development of autoimmune diseases. Circulating autonomic autoantibodies in the sera of patients with silicone breast implants, as well as anatomopathological aspects of small fiber neuropathy in their skin biopsies have been recently described. To our knowledge, these novel insights serve as a common explanation to the non-specific clinical manifestations reported in patients with ASIA, leading to the redefinition of the ASIA syndrome diagnostic criteria.

scholarly journals Subacute thyroiditis post-Pfizer-BioNTech mRNA vaccination for COVID-19

2021 ◽  
Vol 2021 ◽  
Author(s):  
Farooq Khan ◽  
Mary Jane Brassill
Keyword(s):  
Hormone Replacement ◽  
Subacute Thyroiditis ◽  
Antithyroid Drugs ◽  
List Type ◽  
Post Vaccination ◽  
Thyroid Hormone Replacement ◽  
Autoimmune Conditions ◽  
Classical Pattern ◽  
Limiting Condition ◽  
Inflammatory Syndrome

Summary There is emerging evidence of an association between COVID-19 vaccination and subacute thyroiditis. We present the case of a 42-year-old female healthcare worker who was diagnosed with subacute thyroiditis 4 days after receiving her second dose of Pfizer-BioNTech vaccine. Her clinical course followed the classical pattern for thyroiditis with spontaneous return to euthyroidism at 6 months post-presentation. The autoimmune/inflammatory syndrome induced by adjuvants has been implicated as a cause of autoimmune conditions post-vaccination and is a potential mechanism for subacute thyroiditis in our case. Learning points Subacute thyroiditis should be considered in all patients who receive any kind of vaccine for COVID-19 and subsequently develop symptoms or signs of hyperthyroidism or neck pain. Subacute thyroiditis is a self-limiting condition, and recognising it is important as no specific thyroid treatment (antithyroid drugs or thyroid hormone replacement) is necessary for most patients. The autoimmune/inflammatory syndrome induced by adjuvants may be an under-recognised cause of endocrinopathies and should particularly be considered post-vaccination.

Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome) – An update

Lupus ◽  
2017 ◽  
Vol 26 (7) ◽  
pp. 675-681 ◽  
Author(s):  
A Watad ◽  
M Quaresma ◽  
S Brown ◽  
J W Cohen Tervaert ◽  
I Rodríguez-Pint ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Silicone Implants ◽  
Systemic Lupus ◽  
Endogenous Factors ◽  
Immune Mediated ◽  
Autoimmune Conditions ◽  
Asia Syndrome ◽  
Inflammatory Syndrome ◽  
The Relationship

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) has been widely described in many studies conducted thus far. The syndrome incorporates five immune-mediated conditions, all associated with previous exposure to various agents such as vaccines, silicone implants and several others. The emergence of ASIA syndrome is associated with individual genetic predisposition, for instance those carrying HLA-DRB1*01 or HLA-DRB4 and results from exposure to external or endogenous factors triggering autoimmunity. Such factors have been demonstrated as able to induce autoimmunity in both animal models and humans via a variety of proposed mechanisms. In recent years, physicians have become more aware of the existence of ASIA syndrome and the relationship between adjuvants exposure and autoimmunity and more cases are being reported. Accordingly, we have created a registry that includes at present more than 300 ASIA syndrome cases that have been reported by different physicians worldwide, describing various autoimmune conditions induced by diverse adjuvants. In this review, we have summarized the updated literature on ASIA syndrome and the knowledge accumulated since 2013 in order to elucidate the association between the exposure to various adjuvant agents and its possible clinical manifestations. Furthermore, we especially referred to the relationship between ASIA syndrome and systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS).

scholarly journals Association between Silicone Breast Implants and Autoimmune Diseases

2017 ◽  
Author(s):  
Rute Carvalho ◽  
Ana Filipa S. Lima ◽  
Joana Barreira ◽  
Vânia Guedes
Keyword(s):  
Autoimmune Diseases ◽  
Meta Analysis ◽  
Breast Implants ◽  
Adult Women ◽  
Eligibility Criteria ◽  
Silicone Breast Implants ◽  
Mesh Terms ◽  
Long Time ◽  
Asia Syndrome ◽  
Inflammatory Syndrome

BACKGROUND AND AIM: Silicone breast implants have, for a long time, been considered as biologically inert and harmless. However the relationship between silicone breast implants and the risk of autoimmune diseases has generated intense medical interest. The aim of our review is to summarize the data linking silicone breast implants and autoimmune diseases, including the most recent association with autoimmune/inflammatory syndrome induced by adjuvants (ASIA).METHODS: The clinical research included articles from the last 16 years using the MeSH terms “breast implants” and “autoimmune diseases” and also the following terms: “autoimmune/inflammatory syndrome induced by adjuvants” and “Shoenfeld’s syndrome”. The Oxford 2011 Levels of Evidence was used to assign a level-of-evidence.Eligible articles included those who described a population of adult women (>17 years), which have breast implants versus women without implants. The clinical outcome measured was the development of an autoimmune disease.RESULTS: Of the 268 obtained articles, five matched eligibility criteria (one meta-analysis, two systematic reviews and two cohort studies). Results show that although studies could not confirm an association between silicone breast implants and classical autoimmune diseases, a few studies demonstrated an association between implantsand undefined symptoms such as fatigue, arthralgia, myalgia and cognitive symptoms, which resembled a newly introduced syndrome, known as ASIA.CONCLUSIONS: Evidence remains inconclusive about any association between silicone breast implants and classical autoimmune diseases. ASIA seems to be linked to previous exposition to an adjuvant such as silicone. However, we will need better evidence from large studies with accurate methodology to determine whether any true association exists between ASIA syndrome and silicone breast implants.

scholarly journals Dysautonomia Following Tetanus, Diphtheria, and Pertussis Vaccine (Tdap): The First Case of Extreme Cachexia Caused by Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA Syndrome) in a Human

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1333
Author(s):  
Or Hen ◽  
Paula David ◽  
Yehuda Shoenfeld
Keyword(s):  
Pertussis Vaccine ◽  
Adrenergic Receptor ◽  
Orthostatic Intolerance ◽  
First Case ◽  
Generalized Complex ◽  
Autoimmune Conditions ◽  
Asia Syndrome ◽  
Autonomic Receptors ◽  
Inflammatory Syndrome ◽  
Receptor Antibodies

Autoimmune/inflammatory Syndrome Induced by Adjuvants (ASIA; Shoenfeld’s syndrome) comprehends a group of autoimmune conditions that flourish in genetically predisposed individuals, following an external stimulus by the so-called adjuvants. Many adjuvants were described, such as vaccines, aluminum and other metals, silicone, tattoos, among others. Those conditions entail defined diseases, such as sarcoidosis and Sjogren’s syndrome, and generalized complex symptoms, for example, fatigue, sleep disturbance, orthostatic intolerance, and other dysautonomic manifestations. Those complaints were previously associated with autoantibodies against nervous system autonomic receptors, especially antibeta 1 adrenergic receptor antibodies, suggesting the autoimmune component of the condition. Here we report on a case of an 18-year-old woman who presented with extreme cachexia due to severe dysautonomia caused by the ASIA syndrome induced by the tetanus, diphtheria, and pertussis vaccine (Tdap).

scholarly journals AUTOIMMUNE/INFLAMMATORYSYNDROMEINDUCEDBYADJUVANTS (ASIA) - REVISION

2021 ◽  
Vol 9 (5) ◽  
pp. 798-804
Author(s):  
Adriana Novaes Rodrigues
Keyword(s):  
Current Knowledge ◽  
Clinical Manifestations ◽  
Adjuvant Activity ◽  
Autoantibody Production ◽  
Disease Spectrum ◽  
Autoimmune Conditions ◽  
Asia Syndrome ◽  
Specific Symptoms ◽  
Inflammatory Syndrome ◽  
The Relationship

The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), also known as Shoenfeld’s syndrome, encompasses several autoimmune conditions andphenomena that are induced following the exposure to substances with adjuvant activity. The disease spectrum is heterogeneous in respect to clinical presentation as well as severity of the clinical manifestations. Some genetically predisposed individuals can develop generalized non-specific symptoms, autoantibody production, new onset, or worsening of disease presentation. In this review, we focus on the current knowledge presented in the literature on ASIA syndrome, increasing awareness about the basic concepts and highlight the amount of data accumulated in the last few years concerning the relationship between various adjuvants and autoimmunity.

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