scholarly journals Large potassium shifts during dialysis enhance cardiac repolarization instability

2020 ◽  
Author(s):  
Dominik Schüttler ◽  
Ulf Schönermarck ◽  
Felix Wenner ◽  
Marcell Toepfer ◽  
Konstantinos D. Rizas ◽  
...  
Keyword(s):  
Nervous Activity ◽  
Ventricular Myocardium ◽  
Sympathetic Nervous Activity ◽  
Clear Correlation ◽  
The Novel ◽  
Fluid Removal ◽  
Non Invasive ◽  
End Stage ◽  
Present Pilot Study ◽  
Malignant Arrhythmias

Abstract Background Patients with end-stage kidney disease are at high risk for the development of arrhythmias and sudden cardiac death (SCD). This has been especially attributed to large potassium shifts during hemodialysis (HD), and malignant arrhythmias are closely linked to dysfunction of the autonomic nervous system. Nevertheless, there is still a lack of methods for risk stratification in these patients. Methods In the present pilot study we investigated changes of the novel ECG-based biomarker periodic repolarization dynamics (PRD) mirroring the effect of efferent sympathetic nervous activity on the ventricular myocardium in 18 patients undergoing routine hemodialysis. High-resolution ECGs were recorded throughout the dialysis and PRD values were calculated out of 30 min intervals at the start and the end of dialysis. Results We detected a clear correlation between the intradialytic potassium shift and the increase in PRD levels (Spearman correlation coefficient R = 0.62, p = 0.006). Patients with a potassium shift > 1 mmol/l showed significantly increased levels of PRD at the end of dialysis when compared to patients with potassium shifts ≤ 1.0 mmol/l [delta PRD 2.82 (IQR 2.13) vs. − 2.08 (IQR 3.60), p = 0.006]. Spearman analysis showed no significant correlation between PRD changes and fluid removal (R = − 0.23, p = 0.36). Conclusions We provide evidence that large potassium shifts during HD enhance sympathetic activity-associated repolarization instability. This could facilitate the occurrence of malignant arrhythmias, and PRD measurements might serve as a non-invasive monitoring tool in HD patients in future.

Heart rate as a determinant of the decay rate of the cardiac inotropic response to sympathetic nervous activity

1983 ◽  
Vol 61 (11) ◽  
pp. 1374-1381 ◽  
Author(s):  
Yukitaka Masuda ◽  
Matthew N. Levy
Keyword(s):  
Heart Rate ◽  
Sinus Rhythm ◽  
Nervous Activity ◽  
Ventricular Myocardium ◽  
Sympathetic Nervous Activity ◽  
Inotropic Response ◽  
Sympathetic Stimulation ◽  
Junctional Rhythm ◽  
Decay Times ◽  
Inotropic Responses

The cardiac responses to sympathetic nerve stimulation were measured in a series of open-chest, anesthetized dogs. In half the animals, the hearts were in a sinus rhythm; in the remaining animals, the hearts were in an atrioventricular (AV) junctional rhythm. Cocaine markedly prolonged the decay times of the chronotropic responses after cessation of sympathetic stimulation, regardless of the type of rhythm. The decay times of the inotropic responses were only slightly prolonged by cocaine in animals with a sinus rhythm, but the prolongations were pronounced in animals with an AV junctional rhythm. The lower basal heart rate appeared to be more responsible for the greater decay times of the inotropic responses in the animals with an AV junctional rhythm than in those with a sinus rhythm. In a second series of dogs, complete heart block was produced, cocaine was given, AND the hearts were paced at four different frequencies. The mean decay time of the inotropic response to sympathetic stimulation varied inversely AND substantially with the pacing frequency. The change in contraction frequency probably affects the rate of neurotransmitter dissipation from the ventricular myocardium, by altering either the coronary blood flow or the massaging action of the cardiac contractions.

scholarly journals The role of sympathetic nervous activity in renal injury and end-stage renal disease

2010 ◽  
Vol 33 (6) ◽  
pp. 521-528 ◽  
Author(s):  
Kazuko Masuo ◽  
Gavin W Lambert ◽  
Murray D Esler ◽  
Hiromi Rakugi ◽  
Toshio Ogihara ◽  
...  
Keyword(s):  
Renal Disease ◽  
Renal Injury ◽  
End Stage Renal Disease ◽  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Sympathetic Nervous ◽  
Stage Renal Disease ◽  
End Stage

The novel point shear-wave elastography method ElastPQ® is accurate for non-invasive evaluation of liver fibrosis and portal hypertension

2017 ◽  
Vol 55 (05) ◽  
pp. e28-e56
Author(s):  
TA Bucsics ◽  
B Grasl ◽  
P Schwabl ◽  
M Mandorfer ◽  
J Dmitrieva ◽  
...  
Keyword(s):  
Portal Hypertension ◽  
Liver Fibrosis ◽  
Shear Wave ◽  
Shear Wave Elastography ◽  
The Novel ◽  
Non Invasive ◽  
Invasive Evaluation

Sympathetic nervous activity in carriers of MC4R mutations

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
D Heutling ◽  
F Sayk ◽  
C Dodt ◽  
HL Fehm ◽  
A Hinney ◽  
...  
Keyword(s):  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Sympathetic Nervous

scholarly journals Psycho-Electrophysiological Benefits of Forest Therapies Focused on Qigong and Walking with Elderly Individuals

2021 ◽  
Vol 18 (6) ◽  
pp. 3004
Author(s):  
Jiyune Yi ◽  
Seul Gee Kim ◽  
Taegyu Khil ◽  
Minja Shin ◽  
Jin-Hee You ◽  
...  
Keyword(s):  
Urban Forest ◽  
Nervous Activity ◽  
Health Problems ◽  
The Other ◽  
Upper Body ◽  
Sympathetic Nervous Activity ◽  
Control Group ◽  
Beta Band ◽  
Elderly Individuals ◽  
Beneficial Effects

We developed two distinct forest therapy programs (FTPs) and compared their effects on dementia prevention and related health problems for older adults. One was focused on Qigong practice in the forest (QP) and the other involved active walking in the forest (WP). Both FTPs consisted of twelve 2-h sessions over six weeks and were conducted in an urban forest. We obtained data from 25, 18, and 26 participants aged 65 years or above for the QP, WP, and control groups, respectively. Neuropsychological scores via cognition (MoCA), geriatric depression (GDS) and quality of life (EQ-5D), and electrophysiological variables (electroencephalography, bioimpedance, and heart rate variability) were measured. We analyzed the intervention effects with a generalized linear model. Compared to the control group, the WP group showed benefits in terms of neurocognition (increases in the MoCA score, and alpha and beta band power values in the electroencephalogram), sympathetic nervous activity, and bioimpedance in the lower body. On the other hand, the QP group showed alleviated depression and an increased bioimpedance phase angle in the upper body. In conclusion, both active walking and Qigong in the forest were shown to have distinctive neuropsychological and electrophysiological benefits, and both had beneficial effects in terms of preventing dementia and relieving related health problems for elderly individuals.

Sympathetic nervous activity in patients with chronic renal failure

1994 ◽  
Vol 1 ◽  
pp. 314
Author(s):  
E. Gotoh ◽  
T. Matsukawa ◽  
S. Sumita ◽  
K. Ashino ◽  
N. Takagi ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Sympathetic Nervous
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