scholarly journals Stroke Risk Among Non-Elderly Users of Haloperidol or First-Generation Antipsychotics vs Second-Generation Antipsychotics: A Cohort Study from a US Health Insurance Claims Database

Author(s):  
Daniel Fife ◽  
Clair Blacketer ◽  
Karl Knight ◽  
James Weaver
2021 ◽  
Vol 281 ◽  
pp. 539-546
Author(s):  
Ken Inada ◽  
Minori Enomoto ◽  
Kentaro Yamato ◽  
Tatsuro Marumoto ◽  
Masahiro Takeshima ◽  
...  

2021 ◽  
pp. annrheumdis-2021-220439
Author(s):  
Ruriko Koto ◽  
Akihiro Nakajima ◽  
Hideki Horiuchi ◽  
Hisashi Yamanaka

ObjectivesIn patients with gout, treating to target serum uric acid levels (sUA) of ≤6.0 mg/dL is universally recommended to prevent gout flare. However, there is no consensus on asymptomatic hyperuricaemia. Using Japanese health insurance claims data, we explored potential benefits of sUA control for preventing gout flare in subjects with asymptomatic hyperuricaemia.MethodsThis retrospective cohort study analysed the JMDC Claims Database from April 2012 through June 2019. Subjects with sUA ≥8.0 mg/dL were identified, and disease status (prescriptions for urate-lowering therapy (ULT), occurrence of gout flare, sUA) was investigated for 1 year. Time to first onset and incidence rate of gout flare were determined by disease status subgroups for 2 years or more. The relationship between gout flare and sUA control was assessed using multivariable analysis.ResultsThe analysis population was 19 261 subjects who met eligibility criteria. We found fewer occurrences of gout flare, for both gout and asymptomatic hyperuricaemia, in patients who achieved sUA ≤6.0 mg/dL with ULT than in patients whose sUA remained >6.0 mg/dL or who were not receiving ULT. In particular, analysis by a Cox proportional-hazard model for time to first gout flare indicated that the HR was lowest, at 0.45 (95% CI 0.27 to 0.76), in subjects with asymptomatic hyperuricaemia on ULT (5.0<sUA ≤ 6.0 mg/dL), compared with untreated subjects (sUA ≥8.0 mg/dL).ConclusionsOccurrences of gout flare were reduced by controlling sUA at ≤6.0 mg/dL in subjects with asymptomatic hyperuricaemia as well as in those with gout.Trial registration numberUMIN000039985.


2013 ◽  
Vol 03 (04) ◽  
pp. 311-316 ◽  
Author(s):  
Masayoshi Miura ◽  
Keiko Sato ◽  
Hisao Muto ◽  
Kusuma Gopala ◽  
Katsiaryna Holl

2019 ◽  
Vol 47 (6) ◽  
pp. 513-519 ◽  
Author(s):  
Munkhzul Radnaabaatar ◽  
Young‐Eun Kim ◽  
Dun‐Sol Go ◽  
Yunsun Jung ◽  
Jaehun Jung ◽  
...  

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