Is Peritoneal Cytology an Independent Prognostic Factor in Early-Stage Endometrial Cancer?

2021 ◽  
Vol 19 (2) ◽  
Author(s):  
A. K. Padhy ◽  
Mahapatra Manoranjan ◽  
Mishra Jagannath ◽  
Subhashree Rout ◽  
Mohapatra Janmejay ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Prognostic Factor ◽  
Early Stage ◽  
Independent Prognostic Factor ◽  
Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

Impact of positive peritoneal cytology on the survival of early stage endometrial cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 5032-5032
Author(s):  
P. M. Tebeu ◽  
Y. Popowski ◽  
H. M. Verkooijen ◽  
C. Bouchardy ◽  
F. Ludicke ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

Impact of positive peritoneal cytology on the survival of early stage endometrial cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 5032-5032
Author(s):  
P. M. Tebeu ◽  
Y. Popowski ◽  
H. M. Verkooijen ◽  
C. Bouchardy ◽  
F. Ludicke ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

A study of positive peritoneal cytology in patients with early-stage endometrial cancer

2020 ◽  
Vol 59 (3) ◽  
pp. 125-128
Author(s):  
Yoko NISHIMURA ◽  
Motoki MATSUURA ◽  
Masato TAMATE ◽  
Noriko TERADA ◽  
Seiro SATOHISA ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

scholarly journals Positive peritoneal cytology in early-stage endometrial cancer does not influence prognosis

2004 ◽  
Vol 91 (4) ◽  
pp. 720-724 ◽  
Author(s):  
P-M Tebeu ◽  
Y Popowski ◽  
H M Verkooijen ◽  
C Bouchardy ◽  
F Ludicke ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

scholarly journals Positive peritoneal cytology is an independent risk-factor in early stage endometrial cancer

2013 ◽  
Vol 128 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Gunjal Garg ◽  
Feng Gao ◽  
Jason D. Wright ◽  
Andrea R. Hagemann ◽  
David G. Mutch ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

Prognostic Significance of Lymphovascular Space Invasion in the Absence of Lymph Node Metastases in Early-Stage Endometrial Cancer

2018 ◽  
Vol 28 (5) ◽  
pp. 890-894 ◽  
Author(s):  
Ellen Cusano ◽  
Victoria Myers ◽  
Rajiv Samant ◽  
Talia Sudai ◽  
Allison Keller ◽  
...  
Keyword(s):  
Overall Survival ◽  
Endometrial Cancer ◽  
Prognostic Factor ◽  
Early Stage ◽  
Prognostic Significance ◽  
Recurrence Free Survival ◽  
Free Survival ◽  
Node Negative ◽  
Early Stage Endometrial Cancer ◽  
Lymphovascular Space Invasion

ObjectiveLymphovascular space invasion (LVSI) has been defined as a significant adverse prognostic factor in early-stage endometrial cancer, primarily because of its high association with nodal metastases. This study aimed to determine if LVSI provides any prognostic significance in pathologic node-negative surgically staged (T1N0) endometrial cancer patients.Methods/MaterialsThis retrospective cohort study included all patients with pathologic stage T1N0 endometrial carcinoma treated at The Ottawa Hospital Cancer Centre from 1998 to 2007. Patient demographics, pathologic findings, treatment, and outcome data were collected. Univariate and multivariate cox regression modeling was used to assess significance and adjust for demographic and histopathologic covariates. Kaplan-Meier curves were used to estimate the 5-year overall and recurrence-free survival.ResultsOur study included 400 pathologic stage T1N0 patients who received an initial total hysterectomy and bilateral salpingo-oophorectomy with lymphadenectomy. The median age at diagnosis was 62 years, and the median follow-up was 66 months. Fifty-four patients (13.5%) had a positive LVSI status, and 346 (86.5%) had a negative LVSI status. The 5-year overall survival was 97.3% in patients without LVSI and 90.9% in those with LVSI (P < 0.001). The 5-year recurrence-free survival was 95.2% in patients without LVSI and 85.9% in those with LVSI (P = 0.006). Univariate analysis identified grade, stage, and LVSI as the covariates significantly associated with time to recurrence, and identified age, grade, stage, and LVSI to be significantly associated with overall survival. There were no significant covariates for recurrence-free survival by multivariate analysis, and only age and LVSI were significant for overall survival.ConclusionsLymphovascular space invasion is an overall poor prognostic factor in T1N0 endometrial cancer. After adjusting for other factors, LVSI remains an independent risk factor for worse overall survival. Therefore, estimation of overall survival in patients with early-stage, node-negative endometrial cancer should take into account LVSI status.

scholarly journals A Multicentric Randomized Trial to Evaluate the ROle of Uterine MANipulator on Laparoscopic/Robotic HYsterectomy for the Treatment of Early-Stage Endometrial Cancer: The ROMANHY Trial

2021 ◽  
Vol 11 ◽  
Author(s):  
Salvatore Gueli Alletti ◽  
Emanuele Perrone ◽  
Camilla Fedele ◽  
Stefano Cianci ◽  
Tina Pasciuto ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Randomized Trial ◽  
Early Stage ◽  
Pathology Report ◽  
Peritoneal Cytology ◽  
Uterine Manipulator ◽  
Estimated Blood Loss ◽  
Significant Difference ◽  
The Impact ◽  
Early Stage Endometrial Cancer

ObjectiveThis prospective randomized trial aimed to assess the impact of the uterine manipulator in terms of lymph vascular space invasion (LVSI) in patients undergoing minimally invasive staging for early-stage endometrial cancer.MethodsIn this multicentric randomized trial, enrolled patients were randomly allocated in two groups according to the no use (arm A) or the use (arm B) of the uterine manipulator. Inclusion criteria were G1-G2 early-stage endometrial cancer at preoperative evaluation. The variables collected included baseline demographic characteristics, perioperative data, final pathology report, adjuvant treatment, and follow-up.ResultsIn the study, 154 patients (76 in arm A and 78 in arm B) were finally included. No significant differences were recorded regarding the baseline characteristics. A statistically significant difference was found in operative time for the laparoscopic staging (p=0.005), while no differences were reported for the robotic procedures (p=0.419). The estimated blood loss was significantly lower in arm A (p=0.030). No statistically significant differences were recorded between the two study groups in terms of peritoneal cytology, LVSI (p=0.501), and pattern of LVSI (p=0.790). No differences were detected in terms of overall survival and disease-free survival (p=0.996 and p=0.480, respectively). Similarly, no differences were recorded in the number of recurrences, 6 (7.9%) in arm A and 4 (5.2%) in arm B (p=0.486). The use of the uterine manipulator had no impact on DFS both at univariable and multivariable analyses.ConclusionsThe intrauterine manipulator does not affect the LVSI in early-stage endometrial cancer patients undergoing laparoscopic/robotic staging.Clinical Trial Registrationhttps://clinicaltrials.gov, identifier (NCT: 02762214)

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