The aortic media realized Windkessel vessel functions and maintain sustained ventricle ejection balance during cardiac circle. Wheatstone bridge circuit piezoresistive strain sensor had desirable sensing properties to investigate aortic cushion features. In this study, Wheatstone bridge sensor was used to evaluate quick stretching-induced aortic efficient cushions and spontaneous myogenic contractions. Mice aortic specimens were loosely hooked and stabilized to [Formula: see text][Formula: see text]mm stainless steel pin and strain sensor, whereas the other side was hooked and shows increasing specimen length. Specimen isometric tension and rhythmic spontaneous myogenic contraction were recorded. Isometric tension and spontaneous myogenic response at initial length ([Formula: see text] and ultimate length ([Formula: see text] were evaluated. Aortic specimen significantly eliminated mechanical rigid oscillations. The recovery to baseline time was significantly shortened at [Formula: see text] ([Formula: see text][Formula: see text]ms and [Formula: see text] ms at [Formula: see text] and [Formula: see text], respectively, but [Formula: see text][Formula: see text]ms and [Formula: see text][Formula: see text]ms in no-load test). High Ca[Formula: see text] incubation prolonged the recovery time to baseline at [Formula: see text] and [Formula: see text] ([Formula: see text][Formula: see text]ms and [Formula: see text][Formula: see text]ms, respectively) and suggested Ca[Formula: see text] decreased efficient cushion. Moreover, strain sensor successfully recorded the enhanced rhythmic spontaneous myogenic contractions in isometric specimen. Wheatstone bridge circuit sensor reflected the significance of efficient cushions under mechanical preload, which absolutely captured rhythmic myogenic contractions of mice aortic specimen.
A contact lens promising for non-invasive continuous intraocular pressure monitoring
