scholarly journals Outcomes from COVID-19 across the range of frailty: excess mortality in fitter older people

2020 ◽  
Vol 11 (5) ◽  
pp. 851-855 ◽  
Author(s):  
Amy Miles ◽  
Thomas E. Webb ◽  
Benjamin C. Mcloughlin ◽  
Imran Mannan ◽  
Arshad Rather ◽  
...  

Abstract Purpose Our aim was to quantify the mortality from COVID-19 and identify any interactions with frailty and other demographic factors. Methods Hospitalised patients aged ≥ 70 were included, comparing COVID-19 cases with non-COVID-19 controls admitted over the same period. Frailty was prospectively measured and mortality ascertained through linkage with national and local statutory reports. Results In 217 COVID-19 cases and 160 controls, older age and South Asian ethnicity, though not socioeconomic position, were associated with higher mortality. For frailty, differences in effect size were evident between cases (HR 1.02, 95% CI 0.93–1.12) and controls (HR 1.99, 95% CI 1.46–2.72), with an interaction term (HR 0.51, 95% CI 0.37–0.71) in multivariable models. Conclusions Our findings suggest that (1) frailty is not a good discriminator of prognosis in COVID-19 and (2) pathways to mortality may differ in fitter compared with frailer older patients.

Author(s):  
Amy Miles ◽  
Thomas E Webb ◽  
Benjamin C Mcloughlin ◽  
Imran Mannan ◽  
Arshad Rather ◽  
...  

AbstractPurposeOur aim was to quantify the mortality from COVID-19 and identify any interactions with frailty and other demographic factors.MethodsHospitalised patients aged ≥70 were included, comparing COVID-19 cases with non-COVID-19 controls admitted over the same period. Frailty was prospectively measured and mortality ascertained through linkage with national and local statutory reports.ResultsIn 217 COVID-19 cases and 160 controls, older age and South Asian ethnicity, though not socioeconomic position, were associated with higher mortality. For frailty, differences in effect size were evident between cases (HR 1.02, 95%CI 0.93-1.12) and controls (HR 1.99, 95%CI 1.46-2.72), with an interaction term (HR 0.51, 95%CI 0.37-0.71) in multivariable models.ConclusionsOur findings suggest that (i) frailty is not a good discriminator of prognosis in COVID-19 and (ii) pathways to mortality may differ in fitter compared with frailer older patients.Key summary pointsAimTo describe associations between frailty, ethnicity, socioeconomic position and mortality in a cohort of older patients presenting to hospital with COVID-19.


2021 ◽  
Vol 30 ◽  
Author(s):  
Lucy C. Barker ◽  
Susan E. Bronskill ◽  
Hilary K. Brown ◽  
Paul Kurdyak ◽  
Simone N. Vigod

Abstract Aims Social determinants of health have the potential to influence mental health and addictions-related emergency department (ED) visits and the likelihood of admission to hospital. We aimed to determine how social determinants of health, individually and in combination, relate to the likelihood of hospital admission at the time of postpartum psychiatric ED visits. Methods Among 10 702 postpartum individuals (female based on health card) presenting to the ED for a psychiatric reason in Ontario, Canada (2008–2017), we evaluated the relation between six social determinants of health (age, neighbourhood quintile [Q, Q1 = lowest, Q5 = highest], rurality, immigrant category, Chinese or South Asian ethnicity and neighbourhood ethnic diversity) and the likelihood of hospital admission from the ED. Poisson regression models generated relative risks (RR, 95% CI) of admission for each social determinant, crude and adjusted for clinical severity (diagnosis and acuity) and other potential confounders. Generalised estimating equations were used to explore additive interaction to understand whether the likelihood of admission depended on intersections of social determinants of health. Results In total, 16.0% (n = 1715) were admitted to hospital from the ED. Being young (age 19 or less v. 40 or more: RR 0.60, 95% CI 0.45–0.82), rural-dwelling (v. urban-dwelling: RR 0.75, 95% CI 0.62–0.91) and low-income (Q1 v. Q5: RR 0.81, 95% CI 0.66–0.98) were each associated with a lower likelihood of admission. Being an immigrant (non-refugee immigrant v. Canadian-born/long-term resident: RR 1.29, 95% CI 1.06–1.56), of Chinese ethnicity (v. non-Chinese/South Asian ethnicity: RR 1.88, 95% CI 1.42–2.49); and living in the most v. least ethnically diverse neighbourhoods (RR 1.24, 95% CI 1.01–1.53) were associated with a higher likelihood of admission. Only Chinese ethnicity remained significant in the fully-adjusted model (aRR 1.49, 95% CI 1.24–1.80). Additive interactions were non-significant. Conclusions For the most part, whether a postpartum ED visit resulted in admission from the ED depended primarily on the clinical severity of presentation, not on individual or intersecting social determinants of health. Being of Chinese ethnicity did increase the likelihood of admission independent of clinical severity and other measured factors; the reasons for this warrant further exploration.


Heart ◽  
2015 ◽  
Vol 101 (Suppl 4) ◽  
pp. A71-A72
Author(s):  
Alena Shantsila ◽  
Paramjit S Gill ◽  
Eduard Shantsila ◽  
Gregory YH Lip

2018 ◽  
Vol 72 (11) ◽  
pp. 1044-1051 ◽  
Author(s):  
Susitha Wanigaratne ◽  
Pamela Uppal ◽  
Manvir Bhangoo ◽  
Alia Januwalla ◽  
Deepa Singal ◽  
...  

BackgroundSon-biased sex ratios at birth (M:F), an extreme manifestation of son preference, are predominately found in East and South Asia. Studies have examined sex ratios among first-generation migrants from these regions, but few have examined second-generation descendants. Our objective was to determine whether son-biased sex ratios persist among second-generation mothers with South Asian ethnicity in Ontario, Canada.MethodologyA surname algorithm identified a population-based cohort of mothers with South Asian ethnicity who gave birth in Ontario between 1993 and 2014 (n=59 659). Linking to official immigration data identified births to first-generation mothers (ie, immigrants). Births not to immigrants were designated as being to second-generation mothers (ie, born in Canada) (n=10 273). Sex ratios and 95% CI were stratified by the sex of previous live births and by whether it was preceded by ≥1 abortion for both first-generation and second-generation mothers.ResultsAmong mothers with two previous daughters and at least one prior abortion since the second birth, both second-generation mothers and first-generation mothers had elevated sex ratios at the third birth (2.80 (95% CI 1.36 to 5.76) and 2.46 (95% CI 1.93 to 3.12), respectively). However, among mothers with no prior abortion, second-generation mothers had a normal sex ratio, while first-generation mothers gave birth to 142 boys for every 100 girls (95% CI 125 to 162 boys for every 100 girls).ConclusionSon preference persists among second-generation mothers of South Asian ethnicity. Culturally sensitive and community-driven gender equity interventions are needed.


2019 ◽  
Vol 286 ◽  
pp. 105-113 ◽  
Author(s):  
Miguel Cainzos-Achirica ◽  
Ugo Fedeli ◽  
Naveed Sattar ◽  
Charles Agyemang ◽  
Anne K. Jenum ◽  
...  

2018 ◽  
Vol 10 (3) ◽  
pp. 761 ◽  
Author(s):  
Lee Smith ◽  
Guillermo López Sánchez ◽  
Arturo Díaz Suárez ◽  
Brendon Stubbs ◽  
Mathew Dowling ◽  
...  

BMJ Open ◽  
2017 ◽  
Vol 7 (7) ◽  
pp. e015005 ◽  
Author(s):  
Komil N Sarwar ◽  
Phoebe Cliff ◽  
Ponnusamy Saravanan ◽  
Kamlesh Khunti ◽  
Krishnarajah Nirantharakumar ◽  
...  

Cancer ◽  
2018 ◽  
Vol 124 (7) ◽  
pp. 1473-1482 ◽  
Author(s):  
James K.R. Stevenson ◽  
Matthew C. Cheung ◽  
Craig C. Earle ◽  
Hadas D. Fischer ◽  
Ximena Camacho ◽  
...  

2016 ◽  
Vol 3 (1) ◽  
pp. 86 ◽  
Author(s):  
Savitri Singh-Carlson ◽  
Frances Wong ◽  
Gurpreet Oshan ◽  
Harajit Lail

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