scholarly journals Pheochromocytoma/paraganglioma crisis: case series from a tertiary referral center for pheochromocytomas and paragangliomas

HORMONES ◽  
2021 ◽  
Author(s):  
Anouk C Meijs ◽  
Marieke Snel ◽  
Eleonora P M Corssmit

AbstractPheochromocytoma/paraganglioma (PPGL)-induced catecholamine crisis is a rare endocrine emergency leading to life-threatening hemodynamic instability causing end-organ damage or dysfunction. As it is associated with a significant mortality rate of approximately 15%, recognizing the signs and symptoms and making the appropriate diagnosis are critical. For this purpose, we report the clinical course of the crisis in four out of a total of six patients with a PPGL crisis from a cohort of 199 PPGL patients of a single tertiary referral center for PPGL patients in the Netherlands diagnosed between 2002 and 2020. Successful treatment of a PPGL crisis demands prompt diagnosis, vigorous pharmacological therapy, and emergency tumor removal if the patient continues to deteriorate.

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0248010
Author(s):  
Markus Schranz ◽  
Michael Georgopoulos ◽  
Stefan Sacu ◽  
Adrian Reumueller ◽  
Gregor S. Reiter ◽  
...  

Purpose To assess the influence of the SARS-CoV-2 lockdown in spring on frequency, severity and quality of care of rhegmatogeneous retinal detachments (RRD) in a tertiary referral center in Vienna, Austria. Methods Single center, consecutive case series with historical controls. Patients presenting with primary RRD during the first Austrian SARS-CoV-2 lockdown (March 16th–May 3rd 2020) and a corresponding control group consisting of the same time period of the preceding 3 years. Results The mean number of patients with RD in the reference group (RG) was 22 (± 1) and in the lockdown group (LG) 15. Median total delay, defined as onset of symptoms until surgery, in the RG was 5 (lower quartile: 3.0; upper quartile: 8.0) compared to 7 (3.0; 12.0) days in the LG, (p = 0.740). During the lockdown 67% of patients were referred from an external ophthalmologist compared to 52% in the RG, (p = 0.395). 34% of patients in the RG presented with an attached macula compared to 33% in the LG (p = 0.597). PVR was present in 49% of cases in the RG compared to 73% in the LG. Single surgery success (SSS) rates were lower in the LG (73.3%) compared to the RG (85.3%), (p = 0.275). Conclusion Patients with RRD during the SARS-CoV-2 lockdown presented and were treated within acceptable time limits, showed the same macula-on ratios but a higher PVR rate and a tendency towards worse SSS rates compared to the time period of the preceding 3 years.


2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 1002.1-1002
Author(s):  
M. Sarı ◽  
B. Ince ◽  
Y. Ozluk ◽  
B. Erer ◽  
A. Gul ◽  
...  

HPB ◽  
2021 ◽  
Vol 23 ◽  
pp. S900-S901
Author(s):  
J.O. Silva ◽  
C. Robalo ◽  
J. Teixeira Oliveira ◽  
C. Silva ◽  
C. Branco ◽  
...  

2018 ◽  
Vol 33 (7) ◽  
pp. 1218-1224 ◽  
Author(s):  
Çağrι Gülümser ◽  
Mahir Kinap ◽  
Filiz Bilgin Yanik ◽  
Nihal Sahin Uysal ◽  
Gokhan Moray ◽  
...  

2019 ◽  
Vol 4 (2) ◽  
pp. 91-95
Author(s):  
Nicolas A. Yannuzzi ◽  
Karen Brown ◽  
Natalia F. Callaway ◽  
Nimesh A. Patel ◽  
Thomas A. Albini ◽  
...  

Purpose: This article reports the influence of timing on the clinical outcomes in primary extramacular rhegmatogenous retinal detachment (RRD) at a tertiary referral center. Methods: A retrospective case series was conducted of all patients presenting between January 1, 2014 and December 31, 2016, with primary extramacular RRD. Retinal detachments with grade C proliferative vitreoretinopathy, combined tractional and RRD, eyes with inflammatory disease, and prior retinal surgery were excluded. The main outcome measures were single-operation anatomic success (SOAS), final anatomic success, and best-corrected visual acuity (BCVA). Results: There were 202 eyes of 198 patients with an average of 22 months’ follow-up (range, 6-47 months). Eyes were operated on an average of 1.1 days after initial presentation. At last clinical examination, SOAS had been achieved in 174 (86%) eyes, final anatomic success in 200 (99%) eyes, and average postoperative logarithm of the minimum angle of resolution (logMAR) BCVA was 0.18 (Snellen equivalent, 20/30; SD, 0.36). In those treated the day of presentation, average postoperative logMAR BCVA was 0.18 (Snellen, 20/31) in comparison to 0.18 (Snellen, 20/30) in those treated the day after presentation and 0.14 (Snellen, 20/28) in those treated after 2 days or more ( P = .92). Conclusions: Regarding timing of surgery, SOAS and BCVA outcomes in primary extramacular RRDs were favorable with an urgent and semiurgent approach to repair. There was no difference in visual and anatomic outcomes between patients who were operated on the day of presentation and those treated a short time later when clinical decisions were made by the treating surgeon on a case-by-case basis.


Infection ◽  
2012 ◽  
Vol 40 (5) ◽  
pp. 509-515 ◽  
Author(s):  
N. Karadag ◽  
B. S. Karagol ◽  
A. A. Kundak ◽  
A. Dursun ◽  
N. Okumus ◽  
...  

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