scholarly journals Minimally invasive technology for continuous glucose monitoring

2022 ◽  
Author(s):  
Xinshuo Huang ◽  
Jingbo Yang ◽  
Shuang Huang ◽  
Hui-jiuan Chen ◽  
Xi Xie
Keyword(s):  
Minimally Invasive ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring

Minimally invasive and continuous glucose monitoring sensor based on non-enzymatic porous platinum black-coated gold microneedles

2020 ◽  
pp. 137691
Author(s):  
Somasekhar R. Chinnadayyala ◽  
Jinsoo park ◽  
Afraiz T. Satti ◽  
Daeyoung Kim ◽  
Sungbo Cho
Keyword(s):  
Minimally Invasive ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
Platinum Black

scholarly journals A Minimally Invasive Device for Continuous Glucose Monitoring in Infants

2008 ◽  
Vol 2 (2) ◽  
Author(s):  
Christopher P. Erdman ◽  
Stephen M. Goldman ◽  
Patrick J. Lynn ◽  
Matthew C. Ward
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Minimally Invasive ◽  
Neonatal Intensive Care Unit ◽  
Continuous Glucose Monitoring ◽  
Neonatal Intensive Care ◽  
Glucose Monitoring ◽  
Polarized Light ◽  
Invasive Device ◽  
Minimally Invasive Device

Blood sugar management is particularly critical in the neonatal intensive care unit where the incidence of hypoglycemia is high and patients run the risk of brain damage. The staff at most hospitals obtain glucose levels in infants by drawing blood from the heel, which is a cause for recurrent pain. Some infants undergo this procedure every 1–3hours for up to a few months. Our goal is to design a minimally invasive device that allows for real-time glucose monitoring in very low birth weight infants in the neonatal intensive care unit (NICU). This glucose monitor will reduce the amount of pain and physiological stress on the infants, decrease the risk of hypoglycemia in neonates and reduce the workload on hospital staff. There is currently much room for emerging technologies in this market as it trends towards less pain and faster responses. The device should only slightly hinder the infant’s motion, be as painless as possible, and all materials used in contact with the body need to be biologically inert and cause no irritation or allergic reaction. The device will utilize a microneedle array to extract interstitial fluid and draw it through a hydrophilic polyurethane membrane and into a polarimetry chamber. Circularly polarized light will be passed through the chamber and the differential absorbance of left and right polarized light will be used to calculate the glucose concentration. A literature and patent review showed that each separate portion could be used in an effective device for minimally invasive, continuous glucose monitoring.

scholarly journals Delays in Minimally Invasive Continuous Glucose Monitoring Devices: A Review of Current Technology

2009 ◽  
Vol 3 (5) ◽  
pp. 1207-1214 ◽  
Author(s):  
D. Barry Keenan ◽  
John J. Mastrototaro ◽  
Gayane Voskanyan ◽  
Garry M. Steil
Keyword(s):  
Blood Glucose ◽  
Minimally Invasive ◽  
Continuous Glucose Monitoring ◽  
Ex Vivo ◽  
Time Lag ◽  
Glucose Monitoring ◽  
Time Lags ◽  
Continuous Glucose Monitor ◽  
Continuous Glucose Monitors

Through the use of enzymatic sensors—inserted subcutaneously in the abdomen or ex vivo by means of microdialysis fluid extraction—real-time minimally invasive continuous glucose monitoring (CGM) devices estimate blood glucose by measuring a patient's interstitial fluid (ISF) glucose concentration. Signals acquired from the interstitial space are subsequently calibrated with capillary blood glucose samples, a method that has raised certain questions regarding the effects of physiological time lags and of the duration of processing delays built into these devices. The time delay between a blood glucose reading and the value displayed by a continuous glucose monitor consists of the sum of the time lag between ISF and plasma glucose, in addition to the inherent electrochemical sensor delay due to the reaction process and any front-end signal-processing delays required to produce smooth traces. Presented is a review of commercially available, minimally invasive continuous glucose monitors with manufacturer-reported device delays. The data acquisition process for the Medtronic MiniMed (Northridge, CA) continuous glucose monitoring system—CGMS® Gold—and the Guardian® RT monitor is described with associated delays incurred for each processing step. Filter responses for each algorithm are examined using in vitro hypoglycemic and hyperglycemic clamps, as well as with an analysis of fast glucose excursions from a typical meal response. Results demonstrate that the digital filters used by each algorithm do not cause adverse effects to fast physiologic glucose excursions, although nonphysiologic signal characteristics can produce greater delays.

scholarly journals Real-time intradermal continuous glucose monitoring using a minimally invasive microneedle-based system

2018 ◽  
Vol 20 (4) ◽  
Author(s):  
Federico Ribet ◽  
Göran Stemme ◽  
Niclas Roxhed
Keyword(s):  
Minimally Invasive ◽  
Real Time ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring

scholarly journals Calibration of Minimally Invasive Continuous Glucose Monitoring Sensors: State-of-The-Art and Current Perspectives

Biosensors ◽  
2018 ◽  
Vol 8 (1) ◽  
pp. 24 ◽  
Author(s):  
Giada Acciaroli ◽  
Martina Vettoretti ◽  
Andrea Facchinetti ◽  
Giovanni Sparacino
Keyword(s):  
Minimally Invasive ◽  
Continuous Glucose Monitoring ◽  
State Of The Art ◽  
Glucose Monitoring

A patch type non-enzymatic biosensor based on 3D SUS micro-needle electrode array for minimally invasive continuous glucose monitoring

2016 ◽  
Vol 222 ◽  
pp. 1144-1151 ◽  
Author(s):  
Su Jin Lee ◽  
Hyo Sang Yoon ◽  
Xing Xuan ◽  
Jae Y. Park ◽  
Seung-Joon Paik ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
Electrode Array ◽  
Needle Electrode ◽  
Patch Type ◽  
Enzymatic Biosensor

A minimally invasive chip based near infrared sensor for continuous glucose monitoring

2012 ◽  
Author(s):  
L. Ben Mohammadi ◽  
S. Sigloch ◽  
I. Frese ◽  
V. Stein ◽  
K. Welzel ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Continuous Glucose Monitoring ◽  
Near Infrared ◽  
Glucose Monitoring ◽  
Infrared Sensor

Minimally-Invasive and Non-Invasive Continuous Glucose Monitoring Systems: Indications, Advantages, Limitations and Clinical Aspects

2008 ◽  
Vol 4 (3) ◽  
pp. 159-168 ◽  
Author(s):  
Christophe Block ◽  
Jan Vertommen ◽  
Begona Manuel-y-Keenoy ◽  
Luc Gaal
Keyword(s):  
Minimally Invasive ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
Clinical Aspects ◽  
Monitoring Systems ◽  
Non Invasive
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