scholarly journals Positive Functioning Moderates the Association Between Classes of Adverse Childhood Experiences and Adolescent Depressive Symptoms

2021 ◽  
Author(s):  
David W. Sosnowski ◽  
Rashelle J. Musci ◽  
Sara B. Johnson
Keyword(s):  
Depressive Symptoms ◽  
Adverse Childhood Experiences ◽  
Positive Functioning ◽  
Childhood Experiences ◽  
Adolescent Depressive Symptoms ◽  
Adverse Childhood

Maternal adverse childhood experiences and postpartum depressive symptoms in young, low-income women

2021 ◽  
Vol 296 ◽  
pp. 113679
Author(s):  
Sunny H. Shin ◽  
Gabriela Ksinan Jiskrova ◽  
Tiffany Kimbrough ◽  
Karen Tabb Dina ◽  
Elizabeth Overall Lee ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Low Income ◽  
Adverse Childhood Experiences ◽  
Childhood Experiences ◽  
Postpartum Depressive Symptoms ◽  
Adverse Childhood ◽  
Low Income Women

scholarly journals Adverse childhood experiences, daytime salivary cortisol, and depressive symptoms in early adulthood: a longitudinal genetically informed twin study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eleonora Iob ◽  
Jessie R. Baldwin ◽  
Robert Plomin ◽  
Andrew Steptoe
Keyword(s):  
Depressive Symptoms ◽  
Hpa Axis ◽  
Salivary Cortisol ◽  
Adverse Childhood Experiences ◽  
Emotional Abuse ◽  
Early Adulthood ◽  
Cumulative Exposure ◽  
Childhood Experiences ◽  
Adverse Childhood ◽  
Cortisol Levels

AbstractDysregulated hypothalamic–pituitary–adrenal (HPA)-axis function might underlie the relationship between adverse childhood experiences (ACEs) and depression. However, limited research has examined the possible mediating role of the HPA-axis among young people using longitudinal data. Moreover, it remains unclear whether genetic influences could contribute to these associations. Participants were 290 children from the Twins Early Development Study. ACEs were assessed from age 3–11 years. We calculated a cumulative risk score and also derived different ACEs clusters using factor analysis and latent class analysis. HPA-axis activity was indexed by daytime salivary cortisol at age 11. Depressive symptoms were ascertained at age 21. Genetic liability to altered cortisol levels and elevated depressive symptoms was measured using a twin-based method. We performed causal mediation analysis with mixed-effects regression models. The results showed that ACEs cumulative exposure (b = −0.20, p = 0.03), bullying (b = −0.61, p = 0.01), and emotional abuse (b = −0.84, p = 0.02) were associated with lower cortisol levels at age 11. Among participants exposed to multiple ACEs, lower cortisol was related to higher depressive symptoms at age 21 (b = −0.56, p = 0.05). Lower cortisol levels mediated around 10–20% of the total associations of ACEs cumulative exposure, bullying, and dysfunctional parenting/emotional abuse with higher depressive symptoms. Genetic factors contributed to these associations, but the mediation effects of cortisol in the associations of ACEs cumulative exposure (b = 0.16 [0.02–0.34]) and bullying (b = 0.18 [0.01–0.43]) remained when genetic confounding was accounted for. In conclusion, ACEs were linked to elevated depressive symptoms in early adulthood partly through lower cortisol levels in early adolescence, and these relationships were independent of genetic confounding.

scholarly journals Adverse Childhood Experiences, Depressive Symptoms, Functional Dependence, and Physical Activity: A Moderated Mediation Model

2020 ◽  
Vol 17 (8) ◽  
pp. 790-799 ◽  
Author(s):  
Matthieu P. Boisgontier ◽  
Dan Orsholits ◽  
Martina von Arx ◽  
Stefan Sieber ◽  
Matthew W. Miller ◽  
...  
Keyword(s):  
Physical Activity ◽  
Depressive Symptoms ◽  
Adverse Childhood Experiences ◽  
Functional Dependence ◽  
Functional Limitations ◽  
Functional Independence ◽  
Physically Active ◽  
Childhood Experiences ◽  
Moderated Mediation Model ◽  
Adverse Childhood

Background: Adverse childhood experiences, depressive symptoms, and functional dependence are interrelated. However, the mechanisms underlying these associations remain unclear. The authors investigated the potential of depressive symptoms to mediate the effect of adverse childhood experiences on functional dependence in older age and whether physical activity moderated this mediation. Method: Data from 25,775 adults aged 62 (9) years from the Survey of Health Ageing and Retirement in Europe were used in adjusted linear mixed-effects models to test whether depressive symptoms mediated the associations between adverse childhood experiences and functional dependence in activities of daily living (ADL) and instrumental ADL (IADL) and whether physical activity moderated these mediations. Results: The results showed a graded association between the number of adverse childhood experiences (0 vs 1 and 0 vs ≥2) and the number of functional limitations in both ADL (bs = 0.040 and 0.067) and IADL (bs = 0.046 and 0.076). These associations were mediated by depressive symptoms. Physical activity reduced the effect of adverse childhood experiences on depressive symptoms (bs = −0.179 and −0.515) and tempered the effect of depressive symptoms on functional dependence both in ADL (b = −0.073) and IADL (b = −0.100). As a result of these reductions, the effect of adverse childhood experiences and depressive symptoms on functional dependence in ADL (Ps > .081) and IADL (Ps > .528) was nonsignificant in physically active participants. Conclusions: These findings suggest that, after age 50, engaging in physical activity more than once a week protects functional independence from the detrimental effects of adverse childhood experiences and depression. In inactive individuals, the detrimental effects of adverse childhood experiences on functional dependence are mediated by depressive symptoms.

scholarly journals Adverse Childhood Experiences Associated with Epigenetic Age and Depressive Symptoms in Older Adults

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 967-967
Author(s):  
Eric Klopack ◽  
Eileen Crimmins ◽  
Steve Cole ◽  
Teresa Seeman ◽  
Judith Carroll
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Adverse Childhood Experiences ◽  
Physiological Mechanism ◽  
Lifestyle Factors ◽  
Equation Modeling ◽  
Biological Aging ◽  
Older Americans ◽  
Childhood Experiences ◽  
Adverse Childhood

Abstract Adverse childhood experiences (ACEs) increase risk for depression in adolescents and older adults and have been linked to accelerated biological aging. We hypothesized that accelerated epigenetic aging may partially explain the link between ACEs and depression. This study examines second-generation epigenetic clocks (viz., GrimAge, PhenoAge, and DunedinPoAm38) as mediators of the link between ACEs and depressive symptoms in older adulthood. We utilize structural equation modeling to assess mediation in the Innovative Subsample of the Venous Blood Study from the Health and Retirement Study (N = 2672). Results indicate that experiencing more than 1 ACE is significantly associated with greater GrimAge and DunedinPoAm38, with limited evidence of increasing aging with increasing ACEs. GrimAge and DunedinPoAm38 were also significantly associated with more depressive symptoms. These associations were partially reduced by lifestyle factors. GrimAge explained between 9 and 13% of the association between ACEs and adult depressive symptoms, and DunedinPoAm38 explained between 2 and 7% of the association between ACEs and adult depressive symptoms. Findings indicate that accelerated aging, as measured by GrimAge and DunedinPoAm38, is strongly associated with ACEs in older Americans, that these clocks are highly associated with depressive symptoms in older Americans, and that these clocks mediate a proportion of the association between ACEs and adult depressive symptoms. Epigenetic clocks may represent a physiological mechanism underlying the link between early life adversity and adult depression. Lifestyle factors are a potential area for intervention.

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