scholarly journals Adverse childhood experiences, inflammation, and depressive symptoms in later life: a prospective cohort study

The Lancet ◽  
2019 ◽  
Vol 394 ◽  
pp. S58
Author(s):  
Eleonora Iob ◽  
Andrew Steptoe
Keyword(s):  
Cohort Study ◽  
Depressive Symptoms ◽  
Prospective Cohort Study ◽  
Adverse Childhood Experiences ◽  
Prospective Cohort ◽  
Later Life ◽  
Childhood Experiences ◽  
Adverse Childhood

scholarly journals Adverse childhood experiences and future self-rated health: a prospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Alexander Jahn ◽  
Timmi K. Rysgaard ◽  
Johan Hviid Andersen ◽  
Trine Nøhr Winding
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Adverse Childhood Experiences ◽  
Prospective Cohort ◽  
Behavioral Strategies ◽  
Future Health ◽  
Cross Sectional ◽  
Childhood Experiences ◽  
Self Rated Health ◽  
Adverse Childhood

Abstract Background Negative life events (re) occurring during childhood is often described as adverse childhood experiences (ACEs) and may have long-lasting negative effects on health. Previous studies on the association between ACEs and self-rated health (SRH) have primarily been focusing on chronic diseases in elderly, non-Scandinavian populations using a cross-sectional design. The aim of the study was to examine the associations between ACEs and SRH in early adulthood and to investigate if disadvantageous health-behavioral strategies explain the association between ACEs and SRH. Methods A prospective cohort study using data from The West Jutland Cohort Study (N = 2.255). Baseline data on exposure to ACEs were collected from surveys at the age of 15 and 18 and respondents were categorized into having experienced 0, 1–2, 3 or > 4 ACEs. The outcome SRH stems from surveys at the age of 21 and 28 and was dichotomized into moderate and good SRH. The association between ACE-categories and SRH at age 21 and 28 were analyzed separately by logistic regression with a two-step adjustment model, adjusting for potential confounders and disadvantageous health-behavioral strategies. Results More than half of the participants reported at least one ACE (56.3%) with “bullying” and “loss of parent, parental separation or divorce” being the most prevalent. Participants who reported > 4 ACEs, compared to those with 0 ACEs, had a 2.6-fold increased odds (95% CI 1.3; 5.1) of having moderate SRH at the age of 21, and a 2.7-fold increased odds (95% CI 1.4; 5.4) of moderate SRH at the age of 28 years, when adjusted for potential confounders. Further, small attenuations of the estimates were seen when adjusting for disadvantageous health-behavioral strategies. A significant exposure response relationship between the ACE-categories and moderate SRH were seen both at age 21 and 28. Conclusion The study showed an association between ACEs and moderate SRH in young adulthood, and experiencing multiple ACEs increased the odds of reporting moderate SRH. Information on ACEs could help identifying people with a higher risk of future health problems and accentuates a growing need for early prevention in homes with children who has experienced adverse events.

scholarly journals Erratum to: Adverse childhood experiences are associated with the risk of lung cancer: a prospective cohort study

2010 ◽  
Vol 10 (1) ◽  
Author(s):  
David W Brown ◽  
Robert F Anda ◽  
Vincent J Felitti ◽  
Valerie J Edwards ◽  
Ann Marie Malarcher ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Adverse Childhood Experiences ◽  
Prospective Cohort ◽  
Childhood Experiences ◽  
Adverse Childhood

scholarly journals Adverse childhood experiences are associated with the risk of lung cancer: a prospective cohort study

2010 ◽  
Vol 10 (1) ◽  
Author(s):  
David W Brown ◽  
Robert F Anda ◽  
Vincent J Felitti ◽  
Valerie J Edwards ◽  
Ann Marie Malarcher ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Adverse Childhood Experiences ◽  
Prospective Cohort ◽  
Childhood Experiences ◽  
Adverse Childhood

scholarly journals Adverse childhood experiences (ACEs) and later-life depression: perceived social support as a potential protective factor

BMJ Open ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. e013228 ◽  
Author(s):  
E Von Cheong ◽  
Carol Sinnott ◽  
Darren Dahly ◽  
Patricia M Kearney
Keyword(s):  
Social Support ◽  
Depressive Symptoms ◽  
Adverse Childhood Experiences ◽  
Protective Factor ◽  
Perceived Social Support ◽  
Later Life ◽  
Self Report ◽  
Childhood Experiences ◽  
Adverse Childhood ◽  
Socio Demographic Factors

ObjectiveTo investigate associations between adverse childhood experiences (ACEs) and later-life depressive symptoms; and to explore whether perceived social support (PSS) moderates these.MethodWe analysed baseline data from the Mitchelstown (Ireland) 2010–2011 cohort of 2047 men and women aged 50–69 years. Self-reported measures included ACEs (Centre for Disease Control ACE questionnaire), PSS (Oslo Social Support Scale) and depressive symptoms (CES-D). The primary exposure was self-report of at least one ACE. We also investigated the effects of ACE exposure by ACE scores and ACE subtypes abuse, neglect and household dysfunction. Associations between each of these exposures and depressive symptoms were estimated using logistic regression, adjusted for socio-demographic factors. We tested whether the estimated associations varied across levels of PSS (poor, moderate and strong).Results23.7% of participants reported at least one ACE (95% CI 21.9% to 25.6%). ACE exposures (overall, subtype or ACE scores) were associated with a higher odds of depressive symptoms, but only among individuals with poor PSS. Exposure to any ACE (vs none) was associated with almost three times the odds of depressive symptoms (adjusted OR 2.85; 95% CI 1.64 to 4.95) among individuals reporting poor PSS, while among those reporting moderate and strong PSS, the adjusted ORs were 2.21 (95% CI 1.52 to 3.22) and 1.39 (95% CI 0.85 to 2.29), respectively. This pattern of results was similar when exposures were based on ACE subtype and ACE scores, though the interaction was clearly strongest among those reporting abuse.ConclusionsACEs are common among older adults in Ireland and are associated with higher odds of later-life depressive symptoms, particularly among those with poor PSS. Interventions that enhance social support, or possibly perceptions of social support, may help reduce the burden of depression in older populations with ACE exposure, particularly in those reporting abuse.

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