LAYERED DOUBLE HYDROXIDE-BASED MRI/CT DUAL MODAL CONTRASTING AGENT WITH HOMOGENEOUS PARTICLE SIZE

2021 ◽  
Author(s):  
Sang-Yong Jung ◽  
Jin Kuen Park ◽  
Jae-Min Oh
Keyword(s):  
Particle Size ◽  
Layered Double Hydroxide ◽  
Contrasting Agent ◽  
Homogeneous Particle ◽  
Double Hydroxide

scholarly journals Physicochemical Properties and Hematocompatibility of Layered Double Hydroxide-Based Anticancer Drug Methotrexate Delivery System

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1210
Author(s):  
Sang-Yong Jung ◽  
Hyoung-Mi Kim ◽  
Soonjae Hwang ◽  
Do-Gak Jeung ◽  
Ki-Jong Rhee ◽  
...  
Keyword(s):  
Particle Size ◽  
Layered Double Hydroxide ◽  
Anticancer Drug ◽  
Delivery System ◽  
Blood Cells ◽  
Hydrodynamic Radius ◽  
Hydrothermal Reaction ◽  
Membrane Damage ◽  
Double Hydroxide

A layered double hydroxide (LDH)-based anticancer delivery system was investigated in terms of crystalline phase, particle size, hydrodynamic radius, zeta potential, etc. through in vitro and in vivo study. Size controlled LDH with anticancer drug methotrexate (MTX) incorporation was successfully prepared through step-by-step hydrothermal reaction and ion-exchange reaction. The MTX-LDH was determined to have a neutral surface charge and strong agglomeration in the neutral aqueous condition due to the surface adsorbed MTX; however, the existence of proteins in the media dramatically reduced agglomeration, resulting in the hydrodynamic radius of MTX-LDH being similar to the primary particle size. The protein fluorescence quenching assay exhibited that MTX readily reduced the fluorescence of proteins, suggesting that the interaction between MTX and proteins was strong. On the other hand, MTX-LDH showed much less binding constant to proteins compared with MTX, implying that the protein interaction of MTX was effectively blocked by the LDH carrier. The in vivo hemolysis assay after intravenous injection of MTX-LDH showed neither significant reduction in red blood cell number nor membrane damage. Furthermore, the morphology of red blood cells in a mouse model did not change upon MTX-LDH injection. Scanning electron microscopy showed that the MTX-LDH particles were attached on the blood cells without serious denaturation of cellular morphology, taking advantage of the cell hitchhiking property.

scholarly journals Anticancer Activity of Ferulic Acid-Inorganic Nanohybrids Synthesized via Two Different Hybridization Routes, Reconstruction and Exfoliation-Reassembly

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Hyoung-Jun Kim ◽  
Kitae Ryu ◽  
Joo-Hee Kang ◽  
Ae-Jin Choi ◽  
Tae-il Kim ◽  
...  
Keyword(s):  
Particle Size ◽  
Ferulic Acid ◽  
Anticancer Activity ◽  
Layered Double Hydroxide ◽  
Culture Media ◽  
Average Particle Size ◽  
Average Particle ◽  
Cellular Delivery ◽  
Double Hydroxide

We have successfully prepared nanohybrids of biofunctional ferulic acid and layered double hydroxide nanomaterials through reconstruction and exfoliation-reassembly routes. From X-ray diffraction and infrared spectroscopy, both nanohybrids were determined to incorporate ferulic acid molecules in anionic form. Micrsocopic results showed that the nanohybrids had average particle size of 150 nm with plate-like morphology. As the two nanohybridization routes involved crystal disorder and random stacking of layers, the nanohybrids showed slight alteration inz-axis crystallinity and particle size. The zeta potential values of pristine and nanohybrids in deionized water were determined to be positive, while those in cell culture media shifted to negative values. According to thein vitroanticancer activity test on human cervical cancer HeLa cells, it was revealed that nanohybrids showed twice anticancer activity compared with ferulic acid itself. Therefore we could conclude that the nanohybrids of ferulic acid and layered double hydroxide had cellular delivery property of intercalated molecules on cancer cell lines.

Effects of Cu2+ incorporation on ZnAl-layered double hydroxide

2020 ◽  
Vol 44 (14) ◽  
pp. 5293-5302
Author(s):  
Lanyan Wu ◽  
Bing Peng ◽  
Qingzhu Li ◽  
Qingwei Wang ◽  
Xu Yan ◽  
...  
Keyword(s):  
Particle Size ◽  
Coordination Number ◽  
Layered Double Hydroxide ◽  
Double Hydroxide

The incorporation of copper affects the particle size of LDHs and the coordination number of aluminum.

scholarly journals Controlled Growth of Silver Oxide Nanoparticles on the Surface of Citrate Anion Intercalated Layered Double Hydroxide

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 455
Author(s):  
Do-Gak Jeung ◽  
Minseop Lee ◽  
Seung-Min Paek ◽  
Jae-Min Oh
Keyword(s):  
Particle Size ◽  
Layered Double Hydroxide ◽  
Photoelectron Spectroscopy ◽  
Silver Oxide ◽  
Homogeneous Distribution ◽  
Oxide Nanoparticles ◽  
X Ray ◽  
Vis Spectroscopy ◽  
Silver Oxide Nanoparticles ◽  
Double Hydroxide

Silver oxide nanoparticles with controlled particle size were successfully obtained utilizing citrate-intercalated layered double hydroxide (LDH) as a substrate and Ag+ as a precursor. The lattice of LDH was partially dissolved during the reaction by Ag+. The released hydroxyl and citrate acted as a reactant in crystal growth and a size controlling capping agent, respectively. X-ray diffraction, X-ray photoelectron spectroscopy, and microscopic measurements clearly showed the development of nano-sized silver oxide particles on the LDH surface. The particle size, homogeneity and purity of silver oxide were influenced by the stoichiometric ratio of Ag/Al. At the lowest silver ratio, the particle size was the smallest, while the chemical purity was the highest. X-ray photoelectron spectroscopy and UV-vis spectroscopy results suggested that the high Ag/Al ratio tended to produce silver oxide with a complex silver environment. The small particle size and homogeneous distribution of silver oxide showed advantages in antibacterial efficacy compared with bulk silver oxide. LDH with an appropriate ratio could be utilized as a substrate to grow silver oxide nanoparticles with controlled size with effective antibacterial performance.

scholarly journals Synthesis and Characterization of Alkali Free Mg-Al Layered Double Hydroxide for Transesterification of Waste Cooking Oil to Biodiesel: Effect of Mg/Al Ratio

2019 ◽  
Vol 7 (4.14) ◽  
pp. 154
Author(s):  
Erma Hafiza Ibrahim ◽  
Nazrizawati Ahmad Tajuddin ◽  
Noraini Hamzah
Keyword(s):  
Particle Size ◽  
Layered Double Hydroxide ◽  
Fossil Fuels ◽  
Waste Cooking Oil ◽  
Environmental Benefits ◽  
Biodiesel Production ◽  
X Ray ◽  
Cooking Oil ◽  
Co Precipitation ◽  
Double Hydroxide

The depletion of fossil fuels and the concerned toward environmental sustainability have created a considerable to alternate development of sources of energy as substitute for traditional fossil fuels. The biodiesel production has been reported to be an ideal solution as alternative diesel fuel due to its environmental benefits. Thus, the transesterification of waste cooking oil with methanol in the presence of Mg-Al layered double hydroxide (LDHs) as a heterogeneous catalyst was studied to produce the biodiesel. In this work, Mg-Al-LDH was fabricated via alkali free co-precipitation method with final Mg/Al ratio of 4:1, 3:1 and 2:1. The product of co-precipitation was undergone aging process for 24 h. Then it was placed in oven at 100 ⁰C overnight and finally was calcined at 450 ⁰C for 5 h. The correlation of crystallinity, morphology and particle size of Mg-Al-LDH before and after calcined were examined and compared. X-ray diffraction analyse (XRD) was used to study the textural and structural characteristics of the samples. Particle size, morphology and particle properties were characterize by Brunauer, Emmett and Teller (BET) and Scanning electron spectroscopy (SEM). The bonding and structural of Mg-Al-LDH was studied by Fourier transform infrared spectroscopy (FTIR). Energy dispersive X-ray spectroscopy (EDX) was used for the elemental analysis of the samples. The catalytic activity was evaluated by the transesterification reaction under the following reaction condition: temperature (60 ⁰C-65 ⁰C), time (24 h) and methanol to oil ratio (15:1) .The greatest yield was 85.2% and obtained with combination of 4:1 Mg/Al ratio followed by 3:1 and 2:1 ratio.  

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