XRE-Element (Xenobiotic Response Element)

2011 ◽  
Keyword(s):  
Response Element ◽  
Xenobiotic Response Element ◽  
Xenobiotic Response

scholarly journals Xenobiotic response element binding enriched in both nuclear and microsomal fractions of rat cerebellum

2003 ◽  
Vol 85 (1) ◽  
pp. 264-273 ◽  
Author(s):  
Nobuyuki Kuramoto ◽  
Katsuhiro Baba ◽  
Keiko Gion ◽  
Chie Sugiyama ◽  
Hideo Taniura ◽  
...  
Keyword(s):  
Response Element ◽  
Rat Cerebellum ◽  
Xenobiotic Response Element ◽  
Xenobiotic Response

Suppression ofCYP1A1Transcription by H2O2Is Mediated by Xenobiotic-Response Element

1998 ◽  
Vol 356 (2) ◽  
pp. 142-150 ◽  
Author(s):  
Chuanli Xu ◽  
David S. Pasco
Keyword(s):  
Response Element ◽  
Xenobiotic Response Element ◽  
Xenobiotic Response

Detection of a functional xenobiotic response element in a widely employed FoxO-responsive reporter construct

2011 ◽  
Vol 516 (2) ◽  
pp. 138-145 ◽  
Author(s):  
Anna Eckers ◽  
Elisabeth Sauerbier ◽  
Anwar Anwar-Mohamed ◽  
Ingrit Hamann ◽  
Charlotte Esser ◽  
...  
Keyword(s):  
Reporter Construct ◽  
Response Element ◽  
Xenobiotic Response Element ◽  
Xenobiotic Response

The Same Xenobiotic Response Element Is Required for Constitutive and Inducible Expression of the Mammalian Aldehyde Dehydrogenase-3 Gene

1999 ◽  
Vol 361 (2) ◽  
pp. 223-230 ◽  
Author(s):  
Josette S. Boesch ◽  
Robin Miskimins ◽  
W.Keith Miskimins ◽  
Ronald Lindahl
Keyword(s):  
Aldehyde Dehydrogenase ◽  
Inducible Expression ◽  
Response Element ◽  
Xenobiotic Response Element ◽  
Xenobiotic Response

Existence of xenobiotic response element binding in Dictyostelium

2002 ◽  
Vol 1578 (1-3) ◽  
pp. 1-11 ◽  
Author(s):  
Nobuyuki Kuramoto ◽  
Emi Goto ◽  
Yukito Masamune ◽  
Keiko Gion ◽  
Yukio Yoneda
Keyword(s):  
Response Element ◽  
Xenobiotic Response Element ◽  
Xenobiotic Response

scholarly journals Dioxin receptor and C/EBP regulate the function of the glutathione S-transferase Ya gene xenobiotic response element.

1993 ◽  
Vol 13 (7) ◽  
pp. 4365-4373 ◽  
Author(s):  
R A Pimental ◽  
B Liang ◽  
G K Yee ◽  
A Wilhelmsson ◽  
L Poellinger ◽  
...  
Keyword(s):  
Binding Site ◽  
Cell Line ◽  
Specific Antibody ◽  
Binding Protein ◽  
Protein S ◽  
Glutathione S Transferase ◽  
Response Element ◽  
Xenobiotic Response Element ◽  
Xenobiotic Response ◽  
Dioxin Receptor

The rat glutathione S-transferase Ya gene xenobiotic response element (XRE) has both constitutive and xenobiotic-inducible activity. We present evidence that the XRE is regulated by both the constitutive C/EBP transcription factor and the xenobiotic-activated dioxin receptor. A ligand-activated XRE-binding protein was shown to be dioxin receptor by specific antibody immunodepletion and binding of highly purified receptor. Identification of C/EBP alpha as the constitutive binding protein was demonstrated by competition with a C/EBP binding site, protein-DNA cross-linking to determine the molecular weight of the constitutive protein(s), specific antibody immunodepletion, and binding of purified bacterially expressed C/EBP alpha. Mutational analysis of the XRE revealed that the constitutive factor (C/EBP alpha) shares a nearly identical overlapping binding site with the dioxin receptor. In functional testing of the putative C/EBP-XRE interaction, cotransfected C/EBP alpha activated an XRE test promoter in the non-xenobiotic-responsive HeLa cell line. Unexpectedly, cotransfected C/EBP alpha had no effect on basal activity but significantly increased the xenobiotic response of the XRE test promoter in the xenobiotic-responsive, C/EBP-positive HepG2 cell line. Furthermore, inhibition of C/EBP-binding protein(s) in HepG2 cells by transfection of C/EBP oligonucleotides suppressed the xenobiotic response. These results suggest that C/EBP alpha and dioxin receptor recognize the same DNA sequence element and that transcriptional regulation can occur by cooperative interactions between these two transcription factors.

Sign in / Sign up

Export Citation Format

Share Document