Effects of ouabain on cardiac output and pulmonary blood flow in dogs

1972 ◽  
Vol 84 (3) ◽  
pp. 371-376 ◽  
Author(s):  
Elmer Treat ◽  
Harvey Ulano ◽  
Marc Pfeffer ◽  
Walter Massion ◽  
Linda L. Shanbour ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Pulmonary Blood Flow

Single-Breath Breath Holding Measurement of Pulmonary Blood Flow: Comparison to Direct Fick Cardiac Output

1986 ◽  
Vol 71 (s15) ◽  
pp. 36P-36P ◽  
Author(s):  
A.H. Kendrick ◽  
A. Rozkovec ◽  
M. Papouchado ◽  
J. West ◽  
J.E. Bees ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Pulmonary Blood Flow ◽  
Breath Holding ◽  
Single Breath

EVALUATION OF IMPEDANCE CARDIAC OUTPUT IN CHILDREN

PEDIATRICS ◽  
1971 ◽  
Vol 47 (5) ◽  
pp. 870-879
Author(s):  
Zuhdi Lababidi ◽  
D. A. Ehmke ◽  
Robert E. Durnin ◽  
Paul E. Leaverton ◽  
Ronald M. Lauer
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Standard Deviation ◽  
Pulmonary Blood Flow ◽  
Impedance Measurement ◽  
Aortic Insufficiency ◽  
Mean Difference ◽  
Dye Dilution ◽  
Impedance Cardiograph ◽  
Indicator Dye

In 20 children without shunts or valvular insufficiency, duplicate dye dilution and impedance cardiac outputs (ICO) were carried out. The duplicate dye dilutions had a standard deviation 0.259 L/min/m2, while duplicate ICO had a standard deviation 0.192 L/min/m2 (F = 1.82, p < 0.05). Of 53 sequential estimates, cardiac outputs measured by both indicator dye dilution and ICO had a 5.5% mean difference. In 21 subjects with left to right shunts, the ICO related well with pulmonary blood flow (r = 0.92) rather than systemic flow (r = 0.21). In 13 subjects with aortic insufficiency, sequential Fick and ICO had a 50% mean difference; the impedance measurement was found to be higher in every case. These data indicate that the impedance cardiograph can provide a noninvasive measure of cardiac output when there are no shunts or valvular insufficiencies. In subjects with left to right shunts the impedance cardiograph provides a measure of the pulmonary blood flow. When aortic insufficiency exists the impedance cardiograph is distorted such that it is consistently higher than Fick cardiac output.

Single-breath breath-holding estimate of pulmonary blood flow in man: comparison with direct Fick cardiac output

1989 ◽  
Vol 76 (6) ◽  
pp. 673-676 ◽  
Author(s):  
A. H. Kendrick ◽  
A. Rozkovec ◽  
M. Papouchado ◽  
J. West ◽  
G. Laszlo
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Pulmonary Blood Flow ◽  
Hold Time ◽  
Normal Subjects ◽  
Breath Holding ◽  
Breath Hold ◽  
Single Breath ◽  
Significant Difference ◽  
Cardiac Disorders

1. Resting pulmonary blood flow (Q.), using the uptake of the soluble inert gas Freon-22 and an indirect estimate of lung tissue volume, has been estimated during breath-holding (Q.c) and compared with direct Fick cardiac output (Q.f) in 16 patients with various cardiac disorders. 2. The effect of breath-hold time was investigated by comparing Q.c estimated using 6 and 10 s of breath-holding in 17 patients. Repeatability was assessed by duplicate measurements of Q.c in the patients and in six normal subjects. 3. Q.c tended to overestimate Q.f, the bias and error being 0.09 l/min and 0.59, respectively. The coefficient of repeatability for Q.c in the patients was 0.75 l/min and in the normal subjects was 0.66 1/min. For Q.f it was 0.72 l/min. There was no significant difference in Q.c measured at the two breath-hold times. 4. The technique is simple to perform, and provides a rapid estimate of Q., monitoring acute and chronic changes in cardiac output in normal subjects and patients with cardiac disease.

scholarly journals Validation of capnodynamic determination of cardiac output by measuring effective pulmonary blood flow: a study in anaesthetised children and piglets

2018 ◽  
Vol 121 (3) ◽  
pp. 550-558 ◽  
Author(s):  
J. Karlsson ◽  
P. Winberg ◽  
B. Scarr ◽  
P.A. Lönnqvist ◽  
E. Neovius ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Pulmonary Blood Flow

scholarly journals Augmentation of pulmonary blood flow and cardiac output by non-invasive external ventilation late after Fontan palliation

Heart ◽  
2020 ◽  
Vol 107 (2) ◽  
pp. 142-149
Author(s):  
Pradeepkumar Charla ◽  
Gauri Rani Karur ◽  
Kenichiro Yamamura ◽  
Shi-Joon Yoo ◽  
John T Granton ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cardiac Output ◽  
Pulmonary Blood Flow ◽  
Pulmonary Arteries ◽  
Primary Objective ◽  
Non Invasive ◽  
Lateral Tunnel ◽  
The Impact ◽  
Fontan Palliation ◽  
Cmr Imaging

ObjectivesAlthough a life-preserving surgery for children with single ventricle physiology, the Fontan palliation is associated with striking morbidity and mortality with advancing age. Our primary objective was to evaluate the impact of non-invasive, external, thoraco-abdominal ventilation on pulmonary blood flow (PBF) and cardiac output (CO) as measured by cardiovascular magnetic resonance (CMR) imaging in adult Fontan subjects.MethodsAdults with a dominant left ventricle post-Fontan palliation (lateral tunnel or extracardiac connections) and healthy controls matched by sex and age were studied. We evaluated vascular flows using phase-contrast CMR imaging during unassisted breathing, negative pressure ventilation (NPV) and biphasic ventilation (BPV). Measurements were made within target vessels (aorta, pulmonary arteries, vena cavae and Fontan circuit) at baseline and during each ventilation mode.ResultsTen Fontan subjects (50% male, 24.5 years (IQR 20.8–34.0)) and 10 matched controls were studied. Changes in PBF and CO, respectively, were greater following BPV as compared with NPV. In subjects during NPV, PBF increased by 8% (Δ0.20 L/min/m2 (0.10–0.53), p=0.011) while CO did not change significantly (Δ0.17 L/min/m2 (−0.11–0.23), p=0.432); during BPV, PBF increased by 25% (Δ0.61 L/min/m2 (0.20–0.84), p=0.002) and CO increased by 16% (Δ0.47 L/min/m2 (0.21–0.71), p=0.010). Following BPV, change in PBF and CO were both significantly higher in subjects versus controls (0.61 L/min/m2 (0.2–0.84) vs −0.27 L/min/m2 (−0.55–0.13), p=0.001; and 0.47 L/min/m2 (0.21–0.71) vs 0.07 L/min/m2 (−0.47–0.33), p=0.034, respectively).ConclusionExternal ventilation acutely augments PBF and CO in adult Fontan subjects. Confirmation of these findings in larger populations with longer duration of ventilation and extended follow-up will be required to determine sustainability of haemodynamic effects.

Noninvasive diffusing capacity and cardiac output in exercising dogs

1988 ◽  
Vol 65 (2) ◽  
pp. 669-674 ◽  
Author(s):  
J. I. Carlin ◽  
S. S. Cassidy ◽  
U. Rajagopal ◽  
P. S. Clifford ◽  
R. L. Johnson
Keyword(s):  
Blood Flow ◽  
Body Weight ◽  
Cardiac Output ◽  
Steady State ◽  
Pulmonary Blood Flow ◽  
Maximal Exercise ◽  
O2 Consumption ◽  
Diffusing Capacity ◽  
Metabolic Capacity ◽  
End Tidal

We have developed a rebreathing procedure to determine diffusing capacity (DLCO) and pulmonary blood flow (Qc) in the awake, exercising dog. A low dead space, leak-free respiratory mask with an incorporated mouthpiece was utilized to achieve mixing between the rebreathing bag and the dog's lung. The rebreathing bag was initially filled with approximately 1.0 liter of gas containing 0.6% C2H2, 0.3% C18O, 9% He, and 35-40% O2. End-tidal gas concentrations were measured with a respiratory mass spectrometer. The disappearance of C2H2 and C18O was measured with respect to He to calculate Qc and DLCO. Values for DLCO in dogs, expressed per kilogram of body weight, were much larger than those reported in humans. However, at a given level of absolute O2 consumption, measurements of absolute DLCO in dogs were comparable to those reported in humans by both rebreathing and steady-state methods at rest and near-maximal exercise. These results suggest that DLCO is more closely matched to the metabolic capacity (i.e., maximal O2 consumption) than to body size between these two species.

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