The differential diagnosis of coronary artery disease and gastrointestinal disorders∗

1963 ◽  
Vol 12 (3) ◽  
pp. 354-357 ◽  
Author(s):  
Donald Berkowitz
Keyword(s):  
Coronary Artery Disease ◽  
Differential Diagnosis ◽  
Coronary Artery ◽  
Gastrointestinal Disorders ◽  
Artery Disease

scholarly journals Differential diagnosis of chest pain and diagnostic findings in pericardial defects combined with coronary artery disease

1988 ◽  
Vol 11 (9) ◽  
pp. 650-657 ◽  
Author(s):  
W. Auch-Schwelk ◽  
T. Bonzel ◽  
T. Krause ◽  
T. Kroepelin ◽  
B. Wimmer ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Differential Diagnosis ◽  
Chest Pain ◽  
Coronary Artery ◽  
Artery Disease

scholarly journals Incidental cardiac uptake in bone scintigraphy: increased importance and association with cardiac amyloidosis

2021 ◽  
pp. 20200161
Author(s):  
Francis T Delaney ◽  
Philip Dempsey ◽  
Ivan Welaratne ◽  
Bryan Buckley ◽  
Donagh O'Sullivan ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Differential Diagnosis ◽  
Coronary Artery ◽  
Soft Tissue ◽  
Bone Scintigraphy ◽  
Cardiac Amyloidosis ◽  
Cardiac Uptake ◽  
Undiagnosed Disease ◽  
Radiotracer Uptake ◽  
Artery Disease

Extraosseous radiotracer uptake during bone scintigraphy must be carefully assessed and it offers the potential to detect previously undiagnosed disease processes. A range of neoplastic, metabolic, traumatic, ischaemic and inflammatory disorders can cause soft tissue accumulation of bone avid radiopharmaceuticals. Accordingly, cardiac uptake in bone scintigraphy has a broad differential diagnosis and is commonly attributed to ischaemia/infarction related to coronary artery disease. However, there has been renewed focus on incidental cardiac uptake in recent years in light of significant developments in the diagnosis and management of cardiac amyloidosis.

scholarly journals Combination of chronic myocarditis and progressive coronary artery disease: differential diagnosis and stepwise treatment

2020 ◽  
Vol 25 (11) ◽  
pp. 3915
Author(s):  
Yu. A. Lutokhina ◽  
O. V. Blagova ◽  
V. P. Sedov ◽  
V. A. Zaidenov ◽  
A. V. Nedostup
Keyword(s):  
Coronary Artery Disease ◽  
Differential Diagnosis ◽  
Coronary Artery ◽  
Coronary Atherosclerosis ◽  
Left Ventricular ◽  
Coronary Stenting ◽  
Cardiac Conduction ◽  
Shortness Of Breath ◽  
Chronic Myocarditis ◽  
Artery Disease

Aim. To assess the differential diagnosis in a patient with a combination of coronary artery disease and myocarditis and the results of stepwise treatment (including immunosuppressive therapy (IST), and coronary stenting).Material and methods. A 56-year-old female patient with hypertension, obesity (body mass index, 31,6 kg/m2), diabetes and psoriasis developed shortness of breath after a respiratory viral infection. Primary echocardiography revealed left heart dilatation, ejection fraction (EF) of 21%. Coronary angiography revealed anterior descending artery stenosis of 75%, circumflex artery — 80%, right coronary artery (RCA) — 70%. RCA stenting was performed and cardiovascular and diuretic therapy was started. However, shortness of breath and low exercise tolerance persisted.Results. In the blood test, anti-endothelial cell antibodies were 1:320, anticardiomyocyte and anti-smooth muscle antibodies — 1:80, anti-cardiac conduction system fibers — 1:320 (N≤1:40). During myocardial perfusion scintigraphy with computed tomography, an uneven distribution of the indicator was noted. Signs of myocardial scarring and indications for further revascularization were not revealed. Cardiac magnetic resonance imaging confirmed a decrease in left ventricular (LV) contractility (LVEF 37%) and moderate dilatation. Biopsy was not performed due to dual antiplatelet therapy. The condition is regarded as infectious-immune myocarditis. IST was started with azathioprine 150 mg/day. We noted dyspnea relief and a stable increase in LVEF to 50-52%. The clinical course was complicated by sick sinus syndrome with pauses up to 6 seconds and presyncope; a pacemaker was implanted. After 5 years from the onset of IST, dyspnea episodes reappeared without exacerbation of myocarditis. As their cause, ischemia was diagnosed due to the progression of coronary atherosclerosis. Symptoms regressed after repeated coronary stenting.Conclusion. The presence of moderate coronary atherosclerosis without signs of ischemia and myocardial infarction should not be considered as the only cause of severe systolic myocardial dysfunction. Diagnosis and treatment of myocarditis in combination with coronary artery disease is carried out according to the standard principles and can improve LV systolic function and control the heart failure symptoms.

scholarly journals Coronary stent on the move

2021 ◽  
Author(s):  
Hilary Bews ◽  
Tessa Bortoluzzi ◽  
Davinder S Jassal
Keyword(s):  
Coronary Artery Disease ◽  
Differential Diagnosis ◽  
Coronary Artery ◽  
Aortic Dissection ◽  
Aortic Root ◽  
Rare Case ◽  
Stent Migration ◽  
Coronary Stent ◽  
The Past ◽  
Artery Disease

Abstract Over the past three decades, the implantation of coronary stents has revolutionized the management of coronary artery disease. We present a rare case of coronary stent migration in an asymptomatic 72-year-old male, incidentally discovered 9 years after revascularization of the left anterior descending coronary artery for unstable angina. Although a linear echodensity within the aortic root is highly suggestive of an aortic dissection flap, a coronary stent “on the move” should be considered in the differential diagnosis.

scholarly journals Speckle Tracking Echocardiography: Early Predictor of Diagnosis and Prognosis in Coronary Artery Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Maria Concetta Pastore ◽  
Giulia Elena Mandoli ◽  
Francesco Contorni ◽  
Luna Cavigli ◽  
Marta Focardi ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Differential Diagnosis ◽  
Coronary Artery ◽  
Speckle Tracking ◽  
Ventricular Remodeling ◽  
Speckle Tracking Echocardiography ◽  
Left Ventricular Remodeling ◽  
Myocardial Damage ◽  
Left Ventricular ◽  
Artery Disease

Echocardiography represents a first level technique for the evaluation of coronary artery disease (CAD) which supports clinicians in the diagnostic and prognostic workup of these syndromes. However, visual estimation of wall motion abnormalities sometimes fails in detecting less clear or transient myocardial ischemia and in providing accurate differential diagnosis. Speckle tracking echocardiography (STE) is a widely available noninvasive tool that could easily and quickly provide additive information over basic echocardiography, since it is able to identify subtle myocardial damage and to localize ischemic territories in accordance to the coronary lesions, obtaining a clear visualization with a “polar map” useful for differential diagnosis and management. Therefore, it has increasingly been applied in acute and chronic coronary syndromes using rest and stress echocardiography, showing good results in terms of prediction of CAD, clinical outcome, left ventricular remodeling, presence, and quantification of new/residual ischemia. The aim of this review is to illustrate the current available evidence on STE usefulness for the assessment and follow-up of CAD, discussing the main findings on bidimensional and tridimensional strain parameters and their potential application in clinical practice.

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chronic Inflammation ◽  
Ex Vivo ◽  
Human Subjects ◽  
Critical Role ◽  
Atherosclerotic Cardiovascular Disease ◽  
Tnf Α ◽  
Artery Disease

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.

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