The Role of Intraocular Pressure in the Development of the Chick Eye: III. Ciliary Body*

1957 ◽  
Vol 44 (4) ◽  
pp. 85-93 ◽  
Author(s):  
Alfred J. Coulombre ◽  
Jane L. Coulombre
Keyword(s):  
Intraocular Pressure ◽  
Ciliary Body

scholarly journals Involvement of trabecular meshwork phagocytic suppression by sympathetic norepinephrine in nocturnal intraocular pressure rise

2021 ◽  
Author(s):  
Keisuke Ikegami ◽  
Satoru Masubuchi
Keyword(s):  
Circadian Rhythm ◽  
Intraocular Pressure ◽  
Trabecular Meshwork ◽  
Adrenergic Receptor ◽  
Ciliary Body ◽  
Pressure Rise ◽  
Inhibitory Effect ◽  
Pharmacological Prevention ◽  
Signal Activation

Abstract Intraocular pressure (IOP) is important in glaucoma development and depends on aqueous humor (AH) dynamics, involving inflow from the ciliary body and outflow through the trabecular meshwork (TM). IOP has a circadian rhythm entrained by sympathetic noradrenaline (NE) or adrenal glucocorticoids (GCs). Here, we investigated the involvement of GC and NE in AH outflow. Pharmacological prevention of inflow/outflow in mice indicated an AH outflow increase during day. Although TM phagocytosis can determine AH drainage, only NE showed a non-self-sustained inhibitory effect in phagocytosis of immortalized human TM cells. Pharmacological approach and RNA interference identified β1-adrenergic receptor (AR)-mediated cAMP-EPAC-SHIP1 signal activation by ablation of phosphatidylinositol triphosphate regulating phagocytic cup formation. Furthermore, pharmacological instillation in mice revealed the role of β1-AR-EPAC-SHIP1 pathway in nocturnal IOP rise. These suggest that IOP rhythm is partially regulated by this pathway. This first demonstration of TM phagocytosis suppression by NE could be useful in glaucoma management.

Effects of Topical Mitomycin C on the Ciliary Body and Intraocular Pressure After PRK: An Experimental Study

2008 ◽  
Vol 24 (6) ◽  
pp. 633-638 ◽  
Author(s):  
George D. Kymionis ◽  
Spyridon Charisis ◽  
Vasilios F Diakonis ◽  
Aristofanis I Pallikaris ◽  
Sonia H. Yoo ◽  
...  
Keyword(s):  
Experimental Study ◽  
Intraocular Pressure ◽  
Mitomycin C ◽  
Ciliary Body

scholarly journals Intraocular Pressure Measurement Using Ocular Response Analyzer, Dynamic Contour Tonometer, and Scheimpflug Analyzer Corvis ST

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Lisa Ramm ◽  
Robert Herber ◽  
Eberhard Spoerl ◽  
Frederik Raiskup ◽  
Lutz E. Pillunat ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Healthy Subjects ◽  
Corneal Thickness ◽  
Applanation Tonometry ◽  
Ocular Response Analyzer ◽  
Corvis St ◽  
Dynamic Contour Tonometer ◽  
Iop Measurement ◽  
Good Agreement

Purpose. To compare intraocular pressure (IOP) measurements with Goldmann applanation tonometry (GAT), ocular response analyzer (ORA), dynamic contour tonometer (DCT), and Corvis ST (CST) in healthy subjects. Methods. In a prospective, observational study, IOP measurements with GAT (GAT-IOPc), ORA (IOPcc), DCT (DCT-IOP), and CST (bIOP) were performed and analyzed in 94 healthy subjects. Results. Mean age of the participants was 45.6 ± 17.2 years (range 18 to 81 years). Mean GAT-IOPc was 12.9 ± 2.4 mmHg, mean DCT-IOP was 16.1 ± 2.6 mmHg, and mean IOPcc was 15.6 ± 3.3 mmHg. DCT-IOP and IOPcc were significantly higher than GAT-IOPc (P<0.001). Mean bIOP was 13.5 ± 2.4 mmHg that was slightly higher but not significantly different from GAT-IOPc (P=0.146). Correlation analysis of IOP values and central corneal thickness (CCT) revealed a negative correlation between GAT-IOPc and CCT (r = −0.347; P=0.001). However, IOPcc, DCT-IOP, and bIOP showed no significant correlation to CCT. Only bIOP revealed a weak but significant age dependency (r = 0.321, P=0.002). Conclusion. All tonometry devices showed a good agreement of biomechanical corrected IOP values with GAT-IOPc. As no influence of CCT on IOPcc, DCT-IOP, and bIOP was detectable, the used correction algorithms appear to be appropriate in these tonometers in the clinical setting. The highest agreement was found between GAT-IOPc and bIOP. However, bIOP weakly correlated with participants’ age. Further studies are needed to elucidate the role of bIOP for IOP measurement.

Low Intraocular Pressure Resulting from Ciliary Body Detachment in Patients with Myotonic Dystrophy

Ophthalmology ◽  
2011 ◽  
Vol 118 (2) ◽  
pp. 260-264 ◽  
Author(s):  
Nicola Rosa ◽  
Michele Lanza ◽  
Maria Borrelli ◽  
Maddalena De Bernardo ◽  
Alberto Palladino ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Myotonic Dystrophy ◽  
Ciliary Body

The role of mitomycin C and porcine extracellular matrix in phacotrabeculectomy

2020 ◽  
pp. 112067212094433 ◽  
Author(s):  
Momen Mahmoud Hamdi ◽  
Islam Mahmoud Hamdi
Keyword(s):  
Extracellular Matrix ◽  
Intraocular Pressure ◽  
Mitomycin C ◽  
Low Dose ◽  
Open Angle Glaucoma ◽  
Group Iii ◽  
Group I ◽  
Pressure Lowering ◽  
The Mean

Purpose: To compare between mitomycin C alone, porcine extracellular matrix alone, and combined low dose mitomycin C with porcine extracellular matrix in term of efficacy and safety in phaco-trabeculectomy surgery. Study design: Prospective comparative. Methods: Sixty eyes of 60 patients complaining of primary open angle glaucoma and cataract, undergoing phaco-trabeculectomy, were distributed into three groups: group I: surgery was augmented with mitomycin C, group II with porcine extracellular matrix, and group III with porcine extracellular matrix combined with low dose mitomycin C. Intraocular pressure was evaluated, postoperatively, at day 1, week 1, and 1, 3, 6, 9, and 12 months. Bleb vascularity, pre- and post-operative intraocular pressure lowering medications, success of IOP control and complications were also evaluated. Results: After 12 months, the mean preoperative intraocular pressure (mm Hg) improved from 30.85 ± 4.7, 33.8 ± 4.2, and 31.05 ± 5.4 mm Hg, in groups I, II, and III respectively, to 13.8 ± 4.7 (55.2%), 15.2 ± 4.8 (55%), and 13 ± 4.9 (58.1%) ( p > 0.05). Success of IOP control, postoperative IOP lowering medications and complications were comparable ( p > 0.05). Bleb vascularity was significantly different ( p < 0.05). Conclusion: Mitomycin C, porcine extracellular matrix and their combination are equally effective in phacotrabeculectomy.

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