Modulation of glutathione peroxidase activity in human vascular endothelial cells by fatty acids and the cytokine interleukin-1 β

1996 ◽  
Vol 1303 (3) ◽  
pp. 187-192 ◽  
Author(s):  
Anita J Crosby ◽  
Klaus W.J Wahle ◽  
Garry G Duthie
Keyword(s):  
Fatty Acids ◽  
Endothelial Cells ◽  
Glutathione Peroxidase ◽  
Peroxidase Activity ◽  
Vascular Endothelial Cells ◽  
Interleukin 1 ◽  
Vascular Endothelial ◽  
Glutathione Peroxidase Activity

Regulation of glutathione peroxidase (GSHPx) activity in human vascular endothelial cells by fatty acids

1996 ◽  
Vol 24 (2) ◽  
pp. 176S-176S ◽  
Author(s):  
ANITA J. CROSBY ◽  
KLAUS W. J. WAHLE ◽  
GARRY G. DUTHIE ◽  
PHILIP C. MORRICE
Keyword(s):  
Fatty Acids ◽  
Endothelial Cells ◽  
Glutathione Peroxidase ◽  
Vascular Endothelial Cells ◽  
Vascular Endothelial ◽  
Gshpx Activity

scholarly journals The distribution, induction and isoenzyme profile of glutathione S-transferase and glutathione peroxidase in isolated rat liver parenchymal, Kupffer and endothelial cells

1989 ◽  
Vol 264 (3) ◽  
pp. 737-744 ◽  
Author(s):  
P Steinberg ◽  
H Schramm ◽  
L Schladt ◽  
L W Robertson ◽  
H Thomas ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Glutathione Peroxidase ◽  
Rat Liver ◽  
Peroxidase Activity ◽  
Cell Types ◽  
Transferase Activity ◽  
Glutathione Peroxidase Activity ◽  
Glutathione S Transferase ◽  
Liver Parenchymal ◽  
Parenchymal Cells

The distribution and inducibility of cytosolic glutathione S-transferase (EC 2.5.1.18) and glutathione peroxidase (EC 1.11.1.19) activities in rat liver parenchymal, Kupffer and endothelial cells were studied. In untreated rats glutathione S-transferase activity with 1-chloro-2,4-dinitrobenzene and 4-hydroxynon-2-trans-enal as substrates was 1.7-2.2-fold higher in parenchymal cells than in Kupffer and endothelial cells, whereas total, selenium-dependent and non-selenium-dependent glutathione peroxidase activities were similar in all three cell types. Glutathione S-transferase isoenzymes in parenchymal and non-parenchymal cells isolated from untreated rats were separated by chromatofocusing in an f.p.l.c. system: all glutathione S-transferase isoenzymes observed in the sinusoidal lining cells were also detected in the parenchymal cells, whereas Kupffer and endothelial cells lacked several glutathione S-transferase isoenzymes present in parenchymal cells. At 5 days after administration of Arocolor 1254 glutathione S-transferase activity was only enhanced in parenchymal cells; furthermore, selenium-dependent glutathione peroxidase activity decreased in parenchymal and non-parenchymal cells. At 13 days after a single injection of Aroclor 1254 a strong induction of glutathione S-transferase had taken place in all three cell types, whereas selenium-dependent glutathione peroxidase activity remained unchanged (endothelial cells) or was depressed (parenchymal and Kupffer cells). Hence these results clearly establish that glutathione S-transferase and glutathione peroxidase are differentially regulated in rat liver parenchymal as well as non-parenchymal cells. The presence of glutathione peroxidase and several glutathione S-transferase isoenzymes capable of detoxifying a variety of compounds in Kupffer and endothelial cells might be crucial to protect the liver from damage by potentially hepatotoxic substances.

Increased glutathione peroxidase activity in human blood mononuclear cells upon in vitro incubation with n-3 fatty acids

1994 ◽  
Vol 47 (8) ◽  
pp. 1315-1323 ◽  
Author(s):  
Catherine Joulain ◽  
Annie F. Prigent ◽  
Georges Némoz ◽  
Michel Lagarde
Keyword(s):  
Fatty Acids ◽  
Glutathione Peroxidase ◽  
Human Blood ◽  
Peroxidase Activity ◽  
Mononuclear Cells ◽  
Glutathione Peroxidase Activity ◽  
In Vitro Incubation ◽  
Blood Mononuclear Cells

Interleukin-1 production and cell-activation response to cytomegalovirus infection of vascular endothelial cells

1993 ◽  
Vol 133 (3-4) ◽  
pp. 295-308 ◽  
Author(s):  
S. B. Woodroffe ◽  
H. M. Garnett ◽  
V. A. Danis
Keyword(s):  
Endothelial Cells ◽  
Cytomegalovirus Infection ◽  
Cell Activation ◽  
Vascular Endothelial Cells ◽  
Interleukin 1 ◽  
Vascular Endothelial ◽  
Activation Response

scholarly journals G-CSF Protects Human Brain Vascular Endothelial Cells Injury Induced by High Glucose, Free Fatty Acids and Hypoxia through MAPK and Akt Signaling

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0120707 ◽  
Author(s):  
Jingjing Su ◽  
Houguang Zhou ◽  
Yinghong Tao ◽  
Jingchun Guo ◽  
Zhuangli Guo ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Endothelial Cells ◽  
Human Brain ◽  
Free Fatty Acids ◽  
High Glucose ◽  
Vascular Endothelial Cells ◽  
Akt Signaling ◽  
Vascular Endothelial
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