Electrophoretic separation of complexes of aminoacyl-tRNA synthetase and transfer RNA

1967 ◽  
Vol 145 (3) ◽  
pp. 613-620 ◽  
Author(s):  
T. Okamoto ◽  
Y. Kawade
Keyword(s):  
Trna Synthetase ◽  
Transfer Rna ◽  
Electrophoretic Separation ◽  
Aminoacyl Trna Synthetase

scholarly journals Progressive Early-Onset Leukodystrophy Related to Biallelic Variants in the KARS Gene: The First Case Described in Latin America

Genes ◽  
2020 ◽  
Vol 11 (12) ◽  
pp. 1437
Author(s):  
Adriana Vargas ◽  
Jorge Rojas ◽  
Ivan Aivasovsky ◽  
Sergio Vergara ◽  
Marianna Castellanos ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Gene Mutations ◽  
Mitochondrial Respiratory Chain ◽  
Trna Synthetase ◽  
Transfer Rna ◽  
Compound Heterozygous ◽  
Heterozygous State ◽  
Aminoacyl Trna Synthetase ◽  
First Case ◽  
Compound Heterozygous State

The KARS gene encodes the aminoacyl-tRNA synthetase (aaRS), which activates and joins lysine with its corresponding transfer RNA (tRNA) through the ATP-dependent aminoacylation of the amino acid. KARS gene mutations have been linked to diverse neurologic phenotypes, such as neurosensorial hearing loss, leukodystrophy, microcephaly, developmental delay or regression, peripheral neuropathy, cardiomyopathy, the impairment of the mitochondrial respiratory chain, and hyperlactatemia, among others. This article presents the case of a Colombian pediatric patient with two pathological missense variants in a compound heterozygous state in the KARS gene and, in addition to the case report, the paper reviews the literature for other cases of KARS1-associated leukodystrophy.

Progressive Early Onset Leukodystrophy Related to Biallelic Variants in the KARS Gene: The First Case Described in Latin America

2020 ◽  
Author(s):  
Adriana Vargas-Niño ◽  
Jorge Rojas-Martinez ◽  
Ivan Aivasovsky-Trotta ◽  
Sergio Vergara-Cardenas ◽  
Marianna Castellanos-Fernandez ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Gene Mutations ◽  
Mitochondrial Respiratory Chain ◽  
Trna Synthetase ◽  
Transfer Rna ◽  
Compound Heterozygous ◽  
Heterozygous State ◽  
Aminoacyl Trna Synthetase ◽  
First Case ◽  
Compound Heterozygous State

The KARS gene encodes the aminoacyl-tRNA synthetase (aaRS) which activates and joins the lysin with its corresponding transfer RNA (tRNA), through the ATP-dependent aminoacylation of the amino acid. The KARS gene mutations have been linked to diverse neurologic phenotypes such as: neurosensorial hearing loss, leukodistrophy, microcephaly, developmental delay or regression, peripheral neuropathy, cardiomyopathy, impairment of the mitochondrial respiratory chain, hyperlactatemia, among others. This article presents the case of a Colombian pediatric patient with two pathological missense variants in a compound heterozygous state in the KARS gene.

scholarly journals Amino Acid-dependent Transfer RNA Affinity in a Class I Aminoacyl-tRNA Synthetase

2005 ◽  
Vol 280 (25) ◽  
pp. 23966-23977 ◽  
Author(s):  
Nathan T. Uter ◽  
Ita Gruic-Sovulj ◽  
John J. Perona
Keyword(s):  
Amino Acid ◽  
Trna Synthetase ◽  
Transfer Rna ◽  
Class I ◽  
Aminoacyl Trna Synthetase

Directly photocrosslinked nucleotides joining transfer RNA to aminoacyl-tRNA synthetase in methionine and tyrosine systems

1985 ◽  
Vol 181 (1) ◽  
pp. 93-102 ◽  
Author(s):  
Eric J. Ackerman ◽  
Andrzej Joachimiak ◽  
Vered Klinghofer ◽  
Paul B. Sigler
Keyword(s):  
Trna Synthetase ◽  
Transfer Rna ◽  
Aminoacyl Trna Synthetase

Congruence of evidence for a Methanopyrus-proximal root of life based on transfer RNA and aminoacyl-tRNA synthetase genes

Gene ◽  
2005 ◽  
Vol 360 (2) ◽  
pp. 120-130 ◽  
Author(s):  
Hong Xue ◽  
Siu-Kin Ng ◽  
Ka-Lok Tong ◽  
J.Tze-Fei Wong
Keyword(s):  
Trna Synthetase ◽  
Transfer Rna ◽  
Aminoacyl Trna Synthetase

scholarly journals Transfer RNA-dependent cognate amino acid recognition by an aminoacyl-tRNA synthetase.

1996 ◽  
Vol 15 (8) ◽  
pp. 1983-1991 ◽  
Author(s):  
K. W. Hong ◽  
M. Ibba ◽  
I. Weygand-Durasevic ◽  
M. J. Rogers ◽  
H. U. Thomann ◽  
...  
Keyword(s):  
Amino Acid ◽  
Trna Synthetase ◽  
Transfer Rna ◽  
Aminoacyl Trna Synthetase ◽  
Amino Acid Recognition
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