Differential effects of human recombinant interleukin-1β and dexamethasone on hepatic drug-metabolizing enzymes in male and female rats

ABSTRACT Serum levels of LH and of FSH have been measured using specific radioimmunological procedures in normal controls and in male and female rats submitted to castration 1, 2, 7, 14, 21, 28 and 35 days before. Gonadectomy is followed by a rapid increase of serum levels of LH in males, and by a delayed response in females. The responses of serum FSH to castration are quantitatively and qualitatively similar in the two sexes. Both in males and in females an elevation of serum FSH levels is already present 1 day after the operation. Serum FSH continues to rise, between post-castration days 1 and 7 with a rather rapid slope, and at later intervals with a smoother progression.

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Prenatal Aroclor 1254 exposure and brain sexual differentiation: Effect on the expression of testosterone metabolizing enzymes and androgen receptors in the hypothalamus of male and female rats

Reproductive Toxicology ◽

10.1016/j.reprotox.2006.07.002 ◽

2006 ◽

Vol 22 (4) ◽

pp. 738-745 ◽

Cited By ~ 32

Author(s):

A. Colciago ◽

P. Negri-Cesi ◽

A. Pravettoni ◽

O. Mornati ◽

L. Casati ◽

...

Keyword(s):

Sexual Differentiation ◽

Androgen Receptors ◽

Female Rats ◽

Aroclor 1254 ◽

Metabolizing Enzymes ◽

Male And Female ◽

Male And Female Rats ◽

Brain Sexual Differentiation

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Drug induction of hepatic glutathione S-transferases in male and female rats*

Biochemical Journal ◽

10.1042/bj1460351 ◽

1975 ◽

Vol 146 (2) ◽

pp. 351-356 ◽

Cited By ~ 125

Author(s):

N Kaplowitz ◽

J Kuhlekamp ◽

G Clifton

Keyword(s):

Female Rats ◽

Metabolizing Enzymes ◽

Male And Female ◽

Male And Female Rats ◽

Hepatic Glutathione ◽

Drug Induction ◽

Glutathione S Transferases ◽

Proportional Increase ◽

Males And Females ◽

Specific Activities

The induction of the glutathione S-transferases by phenobarbital and polycyclic hydrocarbons was studied in male and female rats. Administration of phenobarbital resulted in 60-80% increase in S-aryl and S-aralkyl enzyme specific activities, whereas the S-epoxide and S-alkyl activities were increased by 30-40%. In following the sequence of induction, the former two activities were noted to reach peak activities before an increase in the latter two activities was observed. Both 3-methylcholanthrene and 3,4-benzopyrene were shown toi nduce these four enzymic activities, although without the discrimination between pairs of activities noted with phenobarbital. No change in Km accompanied the increase in Vmax. after induction by drugs, and no change occurred in Ki for sulphobromophthalein inhibition. Significantly lower enzyme specific activities were found for three of the activities studied in female rats but no difference was observed in the S-alkyltransferase activity. However, the proportional increase in the enzymic activities in response to phenobarbital was the same in males and females. These studies demonstrate the drug induction of a group of cytosolic drug-metabolizing enzymes as well as the identification of sex differences in these activities.

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