Electrical stimulation of neurointermediate lobes of mice elicits calcium-dependent output of melanocyte-stimulating hormone

1986 ◽  
Vol 379 (2) ◽  
pp. 390-393 ◽  
Author(s):  
P. Stephen Taraskevich ◽  
Sally A. Tomiko ◽  
William W. Douglas
Keyword(s):  
Electrical Stimulation ◽  
Calcium Dependent ◽  
Melanocyte Stimulating Hormone ◽  
Stimulation Of ◽  
Stimulating Hormone

COMPARISON OF FOLLICLE-STIMULATING HORMONE AND LUTEINIZING HORMONE SECRETION AFTER ELECTRICAL STIMULATION OF THE PREOPTIC PART OF THE HYPOTHALAMUS IN FEMALE RATS ANAESTHETIZED WITH ETHYL CARBAMATE OR SODIUM PENTOBARBITONE

1978 ◽  
Vol 78 (1) ◽  
pp. 151-152 ◽  
Author(s):  
R. G. DYER ◽  
M. B. TER HAAR ◽  
LINDA C. MAYES
Keyword(s):  
Electrical Stimulation ◽  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Hormone Secretion ◽  
Control Process ◽  
Female Rats ◽  
Female Rat ◽  
Luteinizing Hormone Secretion ◽  
Stimulation Of ◽  
Stimulating Hormone

A.R.C. Institute of Animal Physiology, Babraham, Cambridge, CB2 4AT (Received 17 January 1978) For over 30 years, the method by which the brain regulates the secretion of gonadotrophic hormones has been studied by electrical stimulation of those parts of the central nervous system thought to be implicated in the control process. Much of the work has been performed on the female rat. In this species, anaesthetic doses of sodium pentobarbitone, administered immediately before the pro-oestrous 'critical period', block the preovulatory surge of luteinizing hormone (LH) for 24 h. The same treatment also reduces the early phase of the pro-oestrous secretion of follicle-stimulating hormone (FSH; Daane & Parlow, 1971). Electrical stimulation of the preoptic part of the hypothalamus can overcome this blocking effect and analysis of the optimum parameters required to restore normal secretion of gonadotrophins may give some insight into the endogenous process (e.g. Everett, 1965; Fink & Aiyer, 1974;

scholarly journals Stimulation of the receptor for melanocyte-stimulating hormone by retinoic acid

FEBS Letters ◽  
1990 ◽  
Vol 276 (1-2) ◽  
pp. 205-208 ◽  
Author(s):  
Ashok K. Chakraborty ◽  
Seth J. Orlow ◽  
John M. Pawelek
Keyword(s):  
Retinoic Acid ◽  
Melanocyte Stimulating Hormone ◽  
Stimulation Of ◽  
Stimulating Hormone

Antipyresis caused by stimulation of vasopressinergic neurons and intraseptal or systemic infusions of gamma-MSH

1994 ◽  
Vol 266 (2) ◽  
pp. R614-R621 ◽  
Author(s):  
M. Bock ◽  
J. Roth ◽  
M. J. Kluger ◽  
E. Zeisberger
Keyword(s):  
Electrical Stimulation ◽  
Intramuscular Injection ◽  
Febrile Response ◽  
Melanocyte Stimulating Hormone ◽  
Current Pulses ◽  
Parvocellular Neurons ◽  
The Brain ◽  
Vasopressinergic Neurons ◽  
Infusion Speed ◽  
Stimulation Of

Antipyretic properties have been ascribed to arginine vasopressin (AVP), and the site where its antipyretic effects are mediated in the brain was identified as the ventrolateral septum of the limbic system. In guinea pigs, the majority of AVP projections to the septum originate from parvocellular neurons of the hypothalamic paraventricular nucleus (PVN). Electrical stimulation of the PVN with 10-s trains of current pulses (duration 1 ms, frequency 20 Hz, amplitude 8 V, current 0.205 +/- 0.017 mA) reduced the febrile response to an intramuscular injection of 20 micrograms/kg lipopolysaccharide (LPS from Escherichia coli, 0111: B4) by 54% compared with unstimulated animals. This reduction in fever by electrical PVN stimulation was partly reversed by a simultaneous intraseptal microinfusion of the vasopressinergic V1-receptor antagonist d(CH2)5[Tyr(Met)2]AVP at a concentration of 10(-5) mol for 6 h with an infusion speed of 0.1 microliter/min. We further investigated the effects of intraseptal microinfusions or systemic infusions of the gamma-melanocyte-stimulating hormone (gamma-MSH), a derivative of the proopiomelanocortin, on LPS-induced fever. Intraseptal microinfusions of gamma-MSH at a concentration of 10(-5) mol/l for 6 h with an infusion speed of 0.1 microliter/min caused a 38% reduction in fever. A significantly greater 57% reduction in fever was observed when the intraseptal microinfusion of gamma-MSH was combined with electrical stimulation of the PVN (for parameters see above). A systemic infusion of 0.261 mumol gamma-MSH for 6 h reduced LPS fever to approximately 50% compared with animals infused with vehicle (0.9% saline).(ABSTRACT TRUNCATED AT 250 WORDS)

Sign in / Sign up

Export Citation Format

Share Document