Light microscopic autoradiographic localisation in rat brain of the binding sites for the GABAA receptor antagonist [3H]SR 95531: Comparison with the [3H]GABAA receptor distribution

1988 ◽  
Vol 148 (2) ◽  
pp. 283-288 ◽  
Author(s):  
David R. Bristow ◽  
Ian L. Martin
Keyword(s):  
Receptor Antagonist ◽  
Rat Brain ◽  
Gabaa Receptor ◽  
Binding Sites ◽  
Gabaa Receptor Antagonist ◽  
Sr 95531 ◽  
Receptor Distribution

Songorine, a diterpenoid alkaloid of the genus Aconitum, is a novel GABAA receptor antagonist in rat brain

2003 ◽  
Vol 337 (1) ◽  
pp. 33-36 ◽  
Author(s):  
Xiao-Yan Zhao ◽  
Yuan Wang ◽  
Yang Li ◽  
Xue-Qin Chen ◽  
Hui-Hua Yang ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Rat Brain ◽  
Gabaa Receptor ◽  
Diterpenoid Alkaloid ◽  
Gabaa Receptor Antagonist

Specific binding of a phenyl-pyridazinium derivative endowed with GABAA receptor antagonist activity to rat brain

1986 ◽  
Vol 25 (11) ◽  
pp. 1279-1283 ◽  
Author(s):  
M. Heaulme ◽  
J.P. Chambon ◽  
R. Leyris ◽  
C.G. Wermuth ◽  
K. Biziere
Keyword(s):  
Receptor Antagonist ◽  
Rat Brain ◽  
Gabaa Receptor ◽  
Specific Binding ◽  
Antagonist Activity ◽  
Gabaa Receptor Antagonist

Localization of vasopressin binding sites in rat brain by in vitro autoradiography using a radioiodinated V1 receptor antagonist

Neuroscience ◽  
1988 ◽  
Vol 27 (3) ◽  
pp. 749-761 ◽  
Author(s):  
P.A. Phillips ◽  
J.M. Abrahams ◽  
J. Kelly ◽  
G. Paxinos ◽  
Z. Grzonka ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Rat Brain ◽  
Binding Sites ◽  
In Vitro Autoradiography

The role of brain acetylcholine in GABAA receptor antagonist-induced blood-pressure changes in rat

1996 ◽  
Vol 317 (2-3) ◽  
pp. 301-307 ◽  
Author(s):  
Tahir Tellioǧlu ◽  
Serap Akin ◽  
Uǧur Özkutlu ◽  
Şule Oktay ◽  
Filiz Onat
Keyword(s):  
Blood Pressure ◽  
Receptor Antagonist ◽  
Gabaa Receptor ◽  
Gabaa Receptor Antagonist ◽  
Pressure Changes ◽  
Brain Acetylcholine

scholarly journals Proteomic and Systems Biology Analysis of Monocytes Exposed to Securinine, a GABAA Receptor Antagonist and Immune Adjuvant

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e41278 ◽  
Author(s):  
Matt Shipman ◽  
Kirk Lubick ◽  
David Fouchard ◽  
Rajani Guram ◽  
Paul Grieco ◽  
...  
Keyword(s):  
Systems Biology ◽  
Receptor Antagonist ◽  
Gabaa Receptor ◽  
Gabaa Receptor Antagonist ◽  
Immune Adjuvant

GABA stimulation of gonadotropin-II release in goldfish: involvement of GABAA receptors, dopamine, and sex steroids

1993 ◽  
Vol 265 (2) ◽  
pp. R348-R355 ◽  
Author(s):  
V. L. Trudeau ◽  
B. D. Sloley ◽  
R. E. Peter
Keyword(s):  
Receptor Antagonist ◽  
Gabaa Receptor ◽  
Receptor Agonist ◽  
Gabab Receptor ◽  
Dependent Manner ◽  
Gamma Aminobutyric Acid ◽  
Turnover Rates ◽  
Pharmacological Agents ◽  
Gabaa Receptor Antagonist ◽  
Gonadotropin Ii

The involvement of gamma-aminobutyric acid (GABA) in regulation of pituitary gonadotropin-II (GTH-II) release was studied in the goldfish. Intraperitoneal injection of GABA (300 micrograms/g) stimulated an increase in serum GTH-II levels at 30 min postinjection. The GABAA receptor agonist muscimol (0.1-10 micrograms/g) stimulated GTH-II in a dose-dependent manner. Baclofen, a GABAB receptor agonist, had a small but significant stimulatory effect at 1 and 10 micrograms/g; the amount of GTH-II released in response to baclofen was significantly less (P < 0.05) than that released by muscimol. Pretreatment of goldfish with bicuculline, a GABAA receptor antagonist, but not saclofen, a GABAB receptor antagonist, blocked the stimulatory effect of GABA on serum GTH-II. Elevation of brain and pituitary GABA levels with the GABA transaminase inhibitor, gamma-vinyl-GABA (GVG), decreased hypothalamic and pituitary dopamine (DA) turnover rates, indicating that GABA may stimulate GTH-II release in the goldfish by decreasing dopaminergic inhibition of GTH-II release. The release of GTH-II stimulated by muscimol and GVG was potentiated by pharmacological agents that decrease inhibitory dopaminergic tone, indicating that DA may also inhibit GABA-stimulated GTH-II release. Based on the linear 24-h accumulation of GABA in brain and pituitary after GVG injection, implantation of testosterone, estradiol, or progesterone, previously shown to regulate the serum GTH-II release response to gonadotropin-releasing hormone and GABA, was also found to modulate GABA synthesis in the brain and pituitary.(ABSTRACT TRUNCATED AT 250 WORDS)

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