Apical to basolateral surface area ratio and polarity of MDCK cells grown on different supports

1992 ◽  
Vol 203 (1) ◽  
pp. 115-127 ◽  
Author(s):  
Cécile Butor ◽  
Jean Davoust
2018 ◽  
Vol 22 (8) ◽  
pp. e13295
Author(s):  
Michael E. Chua ◽  
Jin Kyu Kim ◽  
Michele Gnech ◽  
Jessica M. Ming ◽  
Bisma Amir ◽  
...  

2009 ◽  
Vol 13 (3) ◽  
pp. 290-299 ◽  
Author(s):  
Stefano Giuliani ◽  
Pier Giorgio Gamba ◽  
Nikunj Kanu Chokshi ◽  
Paolo Gasparella ◽  
Luisa Murer ◽  
...  

2011 ◽  
Vol 2 (1) ◽  
pp. 35-40
Author(s):  
I. Barányi ◽  
Á. Czifra ◽  
Gabor Kalácska

Surface microtopography plays a dual role in the course of friction and wear processes. It affectsthe contact and temperature conditions, and it undergoes significant changes in accordance with the wearmechanism. Fractal dimension (Df), root mean square gradient (Sdq), surface area ratio (Sdr) and surfacekurtosis (Sku) parameters of microtopographies provides opportunities for understanding more deeply thewear processes independently from the amplitude of the roughness. Wear experiments and surfaceroughness measurements before and after wear were performed. Investigations extended to wear in thecourse of the non-lubricated ferrodo-steel material pairs, and lubricated camshaft-bushing pairs.


Cancers ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 49 ◽  
Author(s):  
Yuji Eso ◽  
Shigeharu Nakano ◽  
Masako Mishima ◽  
Soichi Arasawa ◽  
Eriko Iguchi ◽  
...  

Lenvatinib was recently approved as a novel first-line molecular targeted agent (MTA) for treating hepatocellular carcinoma (HCC). The importance of relative dose intensity (RDI) has been shown in the treatment of various types of cancers. However, RDI may not accurately reflect the treatment intensity of lenvatinib, as it is the first oral MTA where the dose is based on the patient’s weight. We aimed to evaluate the utility of 2M-DBR (the delivered dose intensity/body surface area ratio at 60 days) by comparing the relationship between 2M-DBR, 2M-RDI (RDI at 60 days), and the therapeutic response. The therapeutic response to lenvatinib was evaluated in 45 patients who underwent computed tomography 8–12 weeks after treatment initiation. We also investigated the clinical factors associated with high 2M-DBR. The area under the receiver operating characteristic of 2M-DBR that predicts the response to lenvatinib was higher than that of 2M-RDI (0.8004 vs. 0.7778). Patients with high 2M-DBR achieved significantly better objective responses and disease control rates than those with low 2M-DBR (p < 0.0001 and 0.0008). Patients with high 2M-DBR experienced significantly longer progression-free survival (PFS) than those with low 2M-DBR (p = 0.0001), while there was no significant correlation between 2M-RDI levels and PFS (p = 0.2198). Patients who achieved higher levels of 2M-DBR had a significantly better modified ALBI grade (p = 0.0437), better CONUT score (p = 0.0222), and higher BTR (p = 0.0281). Multivariate analysis revealed that high 2M-DBR was the only significant factor associated with longer PFS. In conclusion, 2M-DBR could be an important factor that reflects treatment intensity and useful for predicting the response to lenvatinib against HCC, instead of 2M-RDI.


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