A circular dichroism and biological activity study on the hybrid species formed from bovine cardiac and rabbit skeletal troponin subunits

FEBS Letters ◽  
1977 ◽  
Vol 83 (1) ◽  
pp. 131-136 ◽  
Author(s):  
M.T. Hincke ◽  
W.D. McCubbin ◽  
C.M. Kay
Keyword(s):  
Biological Activity ◽  
Circular Dichroism ◽  
Hybrid Species ◽  
Circular Dichroïsm

scholarly journals Circular dichroism of bradykinin and related peptides

1971 ◽  
Vol 121 (2) ◽  
pp. 179-184 ◽  
Author(s):  
A. H. Brady ◽  
J. W. Ryan ◽  
J. M. Stewart
Keyword(s):  
Biological Activity ◽  
Circular Dichroism ◽  
Amino Acid ◽  
Amino Acid Composition ◽  
Molecular Interactions ◽  
Biologically Active ◽  
Spectral Features ◽  
Active Peptides ◽  
Biologically Active Peptides ◽  
Circular Dichroïsm

1. The circular dichroism of bradykinin and a number of its analogues and homologues was measured over the spectral range 200–300nm. All of the biologically active peptides showed maxima at 220nm and minima at 235nm. The spectra were independent of solvent and temperature. The vibronic transitions of phenylalanyl residues in the 250–280nm range showed no evidence of intra- or inter-molecular interactions. We take this as evidence that bradykinin and its biologically active analogues and homologues exist in solution as disordered chains. 2. None of the analogues with spectra unlike bradykinin possessed biological activity. However, peptides such as retro-bradykinin, des-6-serine-bradykinin, des-1-arginine-bradykinin and des-9-arginine-bradykinin produced spectra like that of bradykinin but were devoid of biological activity. Although we could not identify spectral features that were clearly correlated with biological activity, it appears unlikely that highly ordered peptides of the same amino acid composition as bradykinin would possess bradykinin-like effects.

Dihydroisocoumarins from fungi: Isolation, structure elucidation, circular dichroism and biological activity

1997 ◽  
Vol 45 (2) ◽  
pp. 313-320 ◽  
Author(s):  
Karsten Krohn ◽  
Rahim Bahramsari ◽  
Ulrich Flörke ◽  
Kerstin Ludewig ◽  
Christine Kliche-Spory ◽  
...  
Keyword(s):  
Biological Activity ◽  
Circular Dichroism ◽  
Structure Elucidation ◽  
Circular Dichroïsm

Synthesis of naturally occurring o-heterocyclic compounds of biological activity

2004 ◽  
Vol 76 (5) ◽  
pp. 1025-1032 ◽  
Author(s):  
Sándor Antus ◽  
Katalin Gulácsi ◽  
László Juhász ◽  
Loránd Kiss ◽  
Tibor Kurtán
Keyword(s):  
Biological Activity ◽  
Circular Dichroism ◽  
Total Synthesis ◽  
Heterocyclic Compounds ◽  
Optical Resolution ◽  
Enantioselective Synthesis ◽  
Ring Closure ◽  
X Ray ◽  
Naturally Occurring ◽  
Circular Dichroïsm

The total synthesis of (−)-cabenegrin A-I was achieved via (−)-6aR,11aR maackiain, which was obtained by optical resolution of racemic maackiain using S-(−)-alpha-methylbenzyl isocyanate. The synthesis of rac-maackiain was performed both with the Heck oxyarylation of 7-benzyloxy-2H-chromene and the BF3OEt2 mediated ring closure of isoflavan-4-ol derivatives, the latter of which provided much higher yields. The first enantioselective synthesis of trans-6aS,11aR-pterocarpan and its conversion to cis-6aS,11aS -ptarocarpan was also presented starting from racemic 2'-benzyloxyflavanone. Their stereochemistry was deduced by circular dichroism (CD) as well as by X-ray analysis of the ketal intermediate.

Characterization of Tamm-Horsfall Urinary Glycoprotein

1973 ◽  
Vol 31 ◽  
pp. 420-421
Author(s):  
John P. Robinson ◽  
J. David Puett
Keyword(s):  
Electron Microscopy ◽  
Circular Dichroism ◽  
Secondary Structure ◽  
Quaternary Structure ◽  
Normal Adult ◽  
Morphological Properties ◽  
Adult Males ◽  
Circular Dichroïsm ◽  
Urinary Glycoprotein

Much work has been reported on the chemical, physical and morphological properties of urinary Tamm-Horsfall glycoprotein (THG). Although it was once reported that cystic fibrotic (CF) individuals had a defective THG, more recent data indicate that THG and CF-THG are similar if not identical.No studies on the conformational aspects have been reported on this glycoprotein using circular dichroism (CD). We examined the secondary structure of THG and derivatives under various conditions and have correlated these results with quaternary structure using electron microscopy.THG was prepared from normal adult males and CF-THG from a 16-year old CF female by the method of Tamm and Horsfall. CF female by the method of Tamm and Horsfall.

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