Modulation of the cross-bridge cycling rate by beta- and muscarinic-receptor stimulation in ferret ventricular muscles K. Hongo, E. Tanaka and S. Kurihara, Department of Physiology, The Jikei University School of Medicine, Tokyo, 105 Japan

1991 ◽  
Vol 23 ◽  
pp. 45
Keyword(s):  
Muscarinic Receptor ◽  
Receptor Stimulation ◽  
Cycling Rate ◽  
Cross Bridge ◽  
School Of Medicine ◽  
The Cross

Effect of acetylcholine infusion on adrenal vasculature and catecholamine secretion

1993 ◽  
Vol 265 (3) ◽  
pp. H966-H972 ◽  
Author(s):  
J. R. Tobin ◽  
M. J. Breslow ◽  
R. J. Traystman
Keyword(s):  
Blood Flow ◽  
Muscarinic Receptor ◽  
Cholinergic Receptor ◽  
Catecholamine Secretion ◽  
Receptor Stimulation ◽  
Similar Dose ◽  
Adrenal Vasculature ◽  
Higher Doses

To evaluate effects of cholinergic receptor stimulation on regional adrenal blood flow (Q, radiolabeled microspheres) and catecholamine secretion, acetylcholine (ACh) was infused into pentobarbital-anesthetized, ventilated dogs. Unilateral adrenal denervation and placement of lumboadrenal catheters preceded intra-aortic infusion of 1) ACh alone (n = 6), 2) ACh plus hexamethonium (Hex) 20 mg/kg (n = 6), or 3) ACh plus atropine (Atr) (0.5 mg/kg) and Hex. ACh alone and in combination with Hex elicited similar dose-related (2, 20, and 100 mumol/min) increases in catecholamine secretion (181 +/- 61 to 1,055 +/- 229, 31,644 +/- 9,411, and 179,181 +/- 69,659 ng.min-1 x g medulla-1), whereas Hex and Atr together inhibited ACh-induced secretion by 95%. ACh caused marked medullary vasodilation (0.71 +/- 0.05 to 0.14 +/- 0.03 mmHg.ml-1 x min.100 g) in all three groups. To determine whether medullary vasodilation was due to incomplete muscarinic blockade, Hex-pretreated animals (n = 4) received ACh (100 mumol/min) and three increasing doses of Atr (0.5, 5, and 25 mg/kg). Catecholamine secretion was inhibited by all doses of Atr; however, vasodilation was blocked only by the two higher doses of Atr. These data suggest possible different mechanisms of muscarinic receptor-mediated catecholamine secretion and vasodilation.

Oxytocin-mediated recruitment of slowly cycling cross bridges and isometric force in rat myometrium

1996 ◽  
Vol 270 (2) ◽  
pp. E203-E208
Author(s):  
A. L. Ruzycky ◽  
B. T. Ameredes
Keyword(s):  
Isometric Force ◽  
Additional Stress ◽  
Shortening Velocity ◽  
Cycling Rate ◽  
Quick Release ◽  
Cross Bridge ◽  
Cross Bridges ◽  
Unit Stress ◽  
Release Method ◽  
The Relationship

The relationship between cross-bridge cycling rate and isometric stress was investigated in rat myometrium. Stress production by myometrial strips was measured under resting, K+ depolarization, and oxytocin-stimulated conditions. Cross-bridge cycling rates were determined from measurements of maximal unloaded shortening velocity, using the quick-release method. Force redevelopment after the quick release was used as an index of cross-bridge attachment. With maximal K+ stimulation, stress increased with increased cross-bridge cycling (+76%; P < 0.05) and attached cross bridges (+112%; P < 0.05). Addition of oxytocin during K+ stimulation further increased stress (+30%; P < 0.05). With this force component, the cross-bridge cycling rate decreased (-60%; P < 0.05) similar to that under resting conditions. Attached cross-bridges did not increase with this additional stress. The results suggest two distinct mechanisms mediating myometrial contractions. One requires elevated intracellular calcium and rapidly cycling cross bridges. The other mechanism may be independent of calcium and appears to be mediated by slowly cycling cross bridges, supporting greater unit stress.

scholarly journals Muscle Length is a Determinant of Cross-Bridge Cycling Rate in Intact Cardiac Trabeculae: Studies from Rodents to Humans

2013 ◽  
Vol 104 (2) ◽  
pp. 315a-316a
Author(s):  
Nima Milani-Nejad ◽  
Ying Xu ◽  
Jonathan P. Davis ◽  
Kenneth S. Campbell ◽  
George S. Billman ◽  
...  
Keyword(s):  
Muscle Length ◽  
Cycling Rate ◽  
Cross Bridge

scholarly journals Elastin Expression in Sacrouterina Ligament is Weaker in the Women with Pelvic Organ Prolapse

2016 ◽  
Author(s):  
Andi Hasnawati
Keyword(s):  
Pelvic Organ Prolapse ◽  
Pelvic Organ ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
School Of Medicine ◽  
Uterosacral Ligaments ◽  
The Cross

Objective: The research aims at comparing the elastin immunolabeling in the uterosacral ligaments in women with pelvic organ prolapse and without pelvic organ prolapse (POP). Methods: The research is done at Dr. Wahidin Sudirohusodo Hospital and education networking some hospitals the Obstetrics and Gynecological School of Medicine Hasanuddin University that began in January 2011 until April 2012. This research assessing expression of elastin on 35 women with a pop level III and IV and as control is 35 women without POP. Immunolabeling of elastin valued in staining checkings immunohistokimia uses antibodies elastin ( clone no. Ba-4 1:1600; Novacastra Laboratories Ltd, UK). The research was carried out by the cross sectional study. Mixed with chi-square. Level significance used is 0.05. Results: The results showed that the elastin immunolabeling in women with POP is decline on most sample expression with the intensity of elastin is weak (74.3%). The most control with the intensity of elastin immunolabeling is moderate (48.6%). Elastin immunolabeling seem significant in women with menopause and with BMI that overweight (all with p

Antilaminin IgG triggers the murine atria phosphoinositide hydrolysis through muscarinic receptor stimulation

1992 ◽  
Vol 14 (8) ◽  
pp. 1321-1328 ◽  
Author(s):  
S. Bacman ◽  
L. Sterin-Borda ◽  
G. Gorelik ◽  
L. Lustig ◽  
B. Denduchis ◽  
...  
Keyword(s):  
Muscarinic Receptor ◽  
Phosphoinositide Hydrolysis ◽  
Receptor Stimulation
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