Lack of LH response to oestradiol treatment in cows with cystic ovarian disease and effect of progesterone treatment or manual rupture

1991 ◽  
Vol 51 (2) ◽  
pp. 180-184 ◽  
Author(s):  
A.S. Nanda ◽  
W.R. Ward ◽  
H. Dobson
Keyword(s):  
Ovarian Disease ◽  
Oestradiol Treatment ◽  
Progesterone Treatment ◽  
Cystic Ovarian Disease

HORMONAL REQUIREMENTS FOR THE MAINTENANCE OF OESTRADIOL-INDUCED INHIBITION OF UTERINE SENSITIVITY IN THE OVARIECTOMIZED RAT

1970 ◽  
Vol 46 (3) ◽  
pp. 341-346 ◽  
Author(s):  
K. P. MEYERS
Keyword(s):  
Subcutaneous Injection ◽  
Ovariectomized Rats ◽  
Ovariectomized Rat ◽  
Single Subcutaneous Injection ◽  
The Third ◽  
Oestradiol Treatment ◽  
Progesterone Treatment ◽  
Endometrial Scratching

SUMMARY Ovariectomized rats treated with 2·5 or 5·0 mg. progesterone daily received a single subcutaneous injection of 0·2 μg. oestradiol on the third day of the progesterone treatment. The deciduomal response to trauma by endometrial scratching was used to determine the degree of uterine sensitivity at various times after oestradiol. Uterine sensitivity was partially and then completely lost 36 and 48 hr. after oestradiol administration. The inhibition of uterine sensitivity persisted until 9 and 11 days after oestradiol when the animals received 2·5 and 5·0 mg. progesterone daily. Uterine sensitivity was completely inhibited on day 11 with doses of oestradiol from 0·2 to 0·05 μg. Withdrawal of progesterone treatment for 48 or 72 hr., but not for 24 hr., after oestradiol treatment restored uterine sensitivity. These results show that the oestradiol-induced inhibition of uterine sensitivity in the progestational endometrium is maintained by continuous progesterone treatment and that the duration of this effect is dependent on the dose of progesterone given.

scholarly journals Follicular structures of cows with cystic ovarian disease present altered expression of cytokines

Zygote ◽  
2019 ◽  
Vol 27 (05) ◽  
pp. 285-298 ◽  
Author(s):  
Antonela F. Stassi ◽  
Natalia C. Gareis ◽  
Belkis E. Marelli ◽  
Valentina Matiller ◽  
Cristian J.M. Leiva ◽  
...  
Keyword(s):  
Growth Factors ◽  
Inflammatory Cytokine ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Concentrations ◽  
Altered Expression ◽  
Ovarian Disease ◽  
Cellular Processes ◽  
Ovarian Cells ◽  
Cystic Ovarian Disease ◽  
Disease Present

SummaryOvulation is considered an inflammatory, cytokine-mediated event. Cytokines, which are recognized as growth factors with immunoregulatory properties, are involved in many cellular processes at the ovarian level. In this sense, cytokines affect fertility and are involved in the development of different ovarian disorders such as bovine cystic ovarian disease (COD). Because it has been previously demonstrated that ovarian cells represent both sources and targets of cytokines, the aim of this study was to examine the expression of several cytokines, including IL-1β, IL-1RA, IL-1RI, IL-1RII, IL-4 and IL-8, in ovarian follicular structures from cows with spontaneous COD. The protein expression of these cytokines was evaluated by immunohistochemistry. Additionally, IL-1β, IL-4 and IL-8 concentrations in follicular fluid (FF) and serum were determined by enzyme-linked immunosorbent assay (ELISA). In granulosa and theca cells, IL-1RI, IL-1RII, IL-1RA and IL-4 expression levels were higher in cystic follicles than in the control dominant follicles. The serum and FF concentrations of IL-1β and IL-4 showed no differences between groups, whereas IL-8 concentration was detected only in FF of cysts from cows with COD. The FF and serum concentrations of IL-1β and IL-8 showed no significant differences, whereas IL-4 concentration was higher in FF than in serum in both the control and COD groups. These results evidenced an altered expression of cytokines in ovaries of cows with COD that could contribute to the pathogenesis of this disease.

Fertility parameters of dairy cows with cystic ovarian disease after treatment with gonadotrophin-releasing hormone

2001 ◽  
Vol 149 (13) ◽  
pp. 383-386 ◽  
Author(s):  
G. A. Hooijer ◽  
M. A. A. J. van Oijen ◽  
K. Frankena ◽  
M. M. H. Valks
Keyword(s):  
Dairy Cows ◽  
Releasing Hormone ◽  
Ovarian Disease ◽  
Gonadotrophin Releasing Hormone ◽  
Cystic Ovarian Disease

Impaired insulin signaling pathway in ovarian follicles of cows with cystic ovarian disease

2015 ◽  
Vol 156 ◽  
pp. 64-74 ◽  
Author(s):  
G.J. Hein ◽  
C.G. Panzani ◽  
F.M. Rodríguez ◽  
N.R. Salvetti ◽  
P.U. Díaz ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Insulin Signaling ◽  
Ovarian Follicles ◽  
Insulin Signaling Pathway ◽  
Ovarian Disease ◽  
Impaired Insulin ◽  
Cystic Ovarian Disease

Alterations in key metabolic sensors involved in bovine cystic ovarian disease

2018 ◽  
Vol 120 ◽  
pp. 138-146 ◽  
Author(s):  
N.C. Gareis ◽  
E. Angeli ◽  
E. Huber ◽  
N.R. Salvetti ◽  
F.M. Rodríguez ◽  
...  
Keyword(s):  
Ovarian Disease ◽  
Cystic Ovarian Disease

Influence of insulin-like growth factor-binding proteins-2 and -3 in the pathogenesis of cystic ovarian disease in cattle

2011 ◽  
Vol 128 (1-4) ◽  
pp. 1-10 ◽  
Author(s):  
Fernanda M. Rodríguez ◽  
Natalia R. Salvetti ◽  
Carolina G. Panzani ◽  
Claudio G. Barbeito ◽  
Hugo H. Ortega ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Ovarian Disease ◽  
Cystic Ovarian Disease

scholarly journals Efficacy of Intravaginal Progesterone Administration Combined with Prostaglandin F2α for Cystic Ovarian Disease in Japanese Black Cows

2008 ◽  
Vol 70 (10) ◽  
pp. 1077-1083
Author(s):  
Akihiro IWAKUMA ◽  
Yoshihito SUZUKI ◽  
Takashi HANEISHI ◽  
Makoto KAJISA ◽  
Shunichi KAMIMURA
Keyword(s):  
Prostaglandin F2α ◽  
Ovarian Disease ◽  
Cystic Ovarian Disease

Insulin resistance: the link between metabolic disorders and cystic ovarian disease in high yielding dairy cows?

1999 ◽  
Vol 56 (3-4) ◽  
pp. 211-222 ◽  
Author(s):  
G. Opsomer ◽  
Th. Wensing ◽  
H. Laevens ◽  
M. Coryn ◽  
A. de Kruif
Keyword(s):  
Insulin Resistance ◽  
Dairy Cows ◽  
Metabolic Disorders ◽  
Ovarian Disease ◽  
Cystic Ovarian Disease
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