Concentration-time-response relationship under conditions of single inhalation of carbon tetrachloride

1985 ◽  
Vol 77 (2) ◽  
pp. 260-266 ◽  
Author(s):  
Nobuo Uemitsu ◽  
Yasushi Minobe ◽  
Hiroshi Nakayoshi
Keyword(s):  
Carbon Tetrachloride ◽  
Time Response ◽  
Response Relationship ◽  
Concentration Time

Time-response relationship of ractopamine feeding on growth performance, plasma urea nitrogen concentration, and carcass traits of finishing pigs1

2013 ◽  
Vol 91 (2) ◽  
pp. 811-818 ◽  
Author(s):  
V. V. Almeida ◽  
A. J. C. Nuñez ◽  
A. P. Schinckel ◽  
C. Andrade ◽  
J. C. C. Balieiro ◽  
...  
Keyword(s):  
Growth Performance ◽  
Nitrogen Concentration ◽  
Carcass Traits ◽  
Time Response ◽  
Response Relationship ◽  
Urea Nitrogen ◽  
Plasma Urea ◽  
Relationship Of

scholarly journals In Vivo Comparison of the Pharmacodynamic Targets for Echinocandin Drugs against Candida Species

2010 ◽  
Vol 54 (6) ◽  
pp. 2497-2506 ◽  
Author(s):  
D. Andes ◽  
D. J. Diekema ◽  
M. A. Pfaller ◽  
J. Bohrmuller ◽  
K. Marchillo ◽  
...  
Keyword(s):  
Candida Glabrata ◽  
Candida Parapsilosis ◽  
Free Drug ◽  
Response Relationship ◽  
Time Curve ◽  
Exposure Response ◽  
Concentration Time ◽  
Drug Concentrations ◽  
Good Descriptor

ABSTRACT Previous pharmacodynamic studies using in vivo candidiasis models have demonstrated that the 24-h area under the concentration-time curve (AUC)/MIC is a good descriptor of the echinocandin exposure-response relationship. Further studies investigating the 24-h AUC/MIC target for a stasis endpoint identified free-drug 24-h AUC/MIC against Candida albicans and were similar for two echinocandins, anidulafungin and micafungin. The current studies expand investigation of a third echinocandin (caspofungin) and compare the pharmacodynamic target among C. albicans, Candida glabrata, and Candida parapsilosis. Treatment studies were conducted with six C. albicans, nine C. glabrata, and 15 C. parapsilosis strains with various MICs (anidulafungin, 0.015 to 4.0 μg/ml; caspofungin, 0.03 to 4.0 μg/ml; and micafungin, 0.008 to 1.0 μg/ml). Efficacy was closely tied to MIC and the 24-h AUC/MIC. Therapy against C. parapsilosis required more of each echinocandin on a mg/kg basis. Caspofungin required less drug on a mg/kg basis for efficacy against all of the organisms than did the other two drugs. However, the 24-h AUC/MIC targets were similar among the echinocandins when free drug concentrations were considered, suggesting the relevance of protein binding. The targets for C. parapsilosis (mean, 7) and C. glabrata (mean, 7) were significantly lower than those for C. albicans (mean, 20) for each echinocandin. The results suggest that current susceptibility breakpoints and the consideration of organism species in these determinations should be reexplored.

scholarly journals Dose-time-response relationship in peanut allergy using a human model of passive cutaneous anaphylaxis

2017 ◽  
Vol 139 (6) ◽  
pp. 2015-2016.e4 ◽  
Author(s):  
Anja P. Mose ◽  
Charlotte G. Mortz ◽  
Esben Eller ◽  
Ulrik Sprogøe ◽  
Torben Barington ◽  
...  
Keyword(s):  
Peanut Allergy ◽  
Time Response ◽  
Human Model ◽  
Passive Cutaneous Anaphylaxis ◽  
Response Relationship ◽  
Dose Time

Investigation of the “dose–time–response” relationships of rhubarb on carbon tetrachloride-induced liver injury in rats

2011 ◽  
Vol 135 (2) ◽  
pp. 575-581 ◽  
Author(s):  
Xiao-yan Xing ◽  
Yan-ling Zhao ◽  
Wei-jun Kong ◽  
Jia-bo Wang ◽  
Lei Jia ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Time Response ◽  
Dose Time
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