The yield of active case-finding in persons with inactive pulmonary tuberculosis or fibrotic lesions A 5-year study in tuberculosis clinics in Amsterdam, Rotterdam and Utrecht☆

Background.One of the main strategies for the early detection of pulmonary tuberculosis (PTB) is through the screening of individuals with symptoms compatible with PTB. Although this is programmatic strategy for active case finding, its yield is not well known.Objective.To determine the yield of pulmonary tuberculosis active case finding through the screening of respiratory symptomatic (RS) patients at a general hospital.Methods.RS patients were defined as subjects complaining of cough and/or sputum for a period of 2 or more weeks. Outpatients and their companions were approached while they waited in the outpatient care areas of the hospital to detect RS. Two samples from different days or 2 samples taken 2 hours apart on the same day were collected.Results.122 RS patients were identified. Fifty-seven patients (46.7%) had at least one sputum sample analyzed. Three patients presented a positive smear and 2 were culture positive; neither had upper airway symptoms. None of the patients with productive cough and upper airway symptoms had a positive smear (). Only 19 (33.3%) returned to the laboratory to retrieve their results.Conclusion.Current strategy to screen RS patients based only on clinical data has a low compliance. Specific strategies to increase compliance (removal of barriers, incentives, etc.) should be implemented.

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Factors affecting applicability of “ home-based interventional model ” for active case finding among household contacts of index cases of pulmonary tuberculosis in Kashmir

Indian Journal of Tuberculosis ◽

10.1016/j.ijtb.2017.01.011 ◽

2017 ◽

Vol 64 (3) ◽

pp. 189-195 ◽

Cited By ~ 1

Author(s):

Ghulam Hassan Khatana ◽

Muneer Masoodi ◽

Mariya Amin

Keyword(s):

Pulmonary Tuberculosis ◽

Case Finding ◽

Active Case Finding ◽

Factors Affecting ◽

Active Case ◽

Household Contacts ◽

Home Based ◽

Index Cases

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Prevalence of bacteriologically confirmed pulmonary tuberculosis in the Bhutanese refugees in Nepal. Results of active case finding

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2010.02.1814 ◽

2010 ◽

Vol 14 ◽

pp. e150 ◽

Cited By ~ 2

Author(s):

O. Gorbacheva ◽

A.K. Mishra ◽

D. Shapovalov ◽

S. Sudtasay

Keyword(s):

Pulmonary Tuberculosis ◽

Case Finding ◽

Active Case Finding ◽

Bhutanese Refugees ◽

Active Case

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Impact of Active Case Finding on Treatment Outcomes in Adult Pulmonary Tuberculosis Patients

Tuberculosis and lung diseases ◽

10.21292/2075-1230-2021-99-7-33-40 ◽

2021 ◽

Vol 99 (7) ◽

pp. 33-40

Author(s):

S. А. Sterlikov ◽

V. B. Gаlkin ◽

B. M. Mаliev ◽

А. А. Shirokovа ◽

V. А. Khorotetto ◽

...

Keyword(s):

Pulmonary Tuberculosis ◽

Treatment Outcomes ◽

Lung Tissue ◽

Case Finding ◽

Adjusted Relative Risk ◽

Active Case Finding ◽

Tissue Destruction ◽

Tuberculosis Patients ◽

Active Case ◽

Risk Of Death

The objective: to assess the effect of active finding of tuberculosis cases on the frequency of bacterial excretion, lung tissue destruction, and treatment outcomes.Subjects and Methods. The characteristics of adult patients (newly detected - new cases and those with relapsed pulmonary tuberculosis) were studied in 2 phases: a) 1,404 cases, including 814 actively found, at detection; b) the outcomes of the completed first course of chemotherapy in 946 patients, including 565 actively detected, registered for treatment in 2017 and 2018. Adjusted relative risk (aOR) and statistical significance of differences were calculated.Results. Patients detected actively versus those detected by self presentation to a medical unit had a lower level of positive results of smear microscopy (aOR = 2.7; p < 0.01) and lung tissue destruction (aOR = 1.4; p = 0.01), but the level of positive culture was equal (aOR = 0.9; p = 0.6). Active case finding had no effect on treatment failure rate but if a patient is HIV negative and young, it reduced the risk of death in tuberculosis patients during treatment (aOR = 0.3; p < 0.01). Active case finding, along with no history of previous treatment, negative HIV status, and older age were inversely associated with treatment interruption (aOR = 0.3; p < 0.01).

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