Factors affecting applicability of “ home-based interventional model ” for active case finding among household contacts of index cases of pulmonary tuberculosis in Kashmir

Background.One of the main strategies for the early detection of pulmonary tuberculosis (PTB) is through the screening of individuals with symptoms compatible with PTB. Although this is programmatic strategy for active case finding, its yield is not well known.Objective.To determine the yield of pulmonary tuberculosis active case finding through the screening of respiratory symptomatic (RS) patients at a general hospital.Methods.RS patients were defined as subjects complaining of cough and/or sputum for a period of 2 or more weeks. Outpatients and their companions were approached while they waited in the outpatient care areas of the hospital to detect RS. Two samples from different days or 2 samples taken 2 hours apart on the same day were collected.Results.122 RS patients were identified. Fifty-seven patients (46.7%) had at least one sputum sample analyzed. Three patients presented a positive smear and 2 were culture positive; neither had upper airway symptoms. None of the patients with productive cough and upper airway symptoms had a positive smear (). Only 19 (33.3%) returned to the laboratory to retrieve their results.Conclusion.Current strategy to screen RS patients based only on clinical data has a low compliance. Specific strategies to increase compliance (removal of barriers, incentives, etc.) should be implemented.

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Targeted Active Case Finding in Household Contacts of Smear Positive Tuberculosis Patients in a High Incidence Urban Setting

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2008.05.903 ◽

2008 ◽

Vol 12 ◽

pp. e338

Author(s):

B. Mutayoba ◽

S. Mfinanga ◽

O. Morkve

Keyword(s):

Case Finding ◽

Urban Setting ◽

Active Case Finding ◽

Tuberculosis Patients ◽

Active Case ◽

Household Contacts ◽

High Incidence

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Active Case-Finding Of Tuberculosis Among Household Contacts In Hanoi, Vietnam - A 12 Month Prospective Study

10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3248 ◽

2012 ◽

Cited By ~ 1

Author(s):

Gregory J. Fox ◽

Dinh Ngoc Sy ◽

Nguyen Viet Nhung ◽

Luu T. Lien ◽

Nguyen Kim Cuong ◽

...

Keyword(s):

Prospective Study ◽

Case Finding ◽

Active Case Finding ◽

Active Case ◽

Household Contacts

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The Use of Xpert MTB/Rif for Active Case Finding among TB Contacts in North West Province, South Africa

Tuberculosis Research and Treatment ◽

10.1155/2016/4282313 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Limakatso Lebina ◽

Nigel Fuller ◽

Tolu Osoba ◽

Lesley Scott ◽

Katlego Motlhaoleng ◽

...

Keyword(s):

Diagnostic Yield ◽

Turnaround Time ◽

Case Finding ◽

Contact Tracing ◽

Active Case Finding ◽

North West ◽

Active Case ◽

Household Contacts ◽

Significant Difference ◽

Diagnosis Rate

Introduction.Tuberculosis is a major cause of morbidity and mortality especially in high HIV burden settings. Active case finding is one strategy to potentially reduce TB disease burden. Xpert MTB/Rif has recently been recommended for diagnosis of TB.Methods.Pragmatic randomized trial to compare diagnosis rate and turnaround time for laboratory testing for Xpert MTB/Rif with TB microscopy and culture in household contacts of patients recently diagnosed with TB.Results.2464 household contacts enrolled into the study from 768 active TB index cases. 1068 (44%) were unable to give sputum, but 24 of these were already on TB treatment. 863 (53%) participants sputum samples were tested with smear and culture and 2.7% (23/863; CI: 1.62–3.78) were diagnosed with active TB. Xpert MTB/Rif was used in 515 (21%) participants; active TB was diagnosed in 1.6% (8/515; CI: 0.52–2.68).Discussion and Conclusions.Additional 31 cases were diagnosed with contact tracing of household members. When Xpert MTB/Rif is compared with culture, there is no significant difference in diagnostic yield.

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