Honeybee venom: A rich source of pharmacologically active peptides

Endeavour ◽  
1988 ◽  
Vol 12 (2) ◽  
pp. 60-65 ◽  
Author(s):  
Robert C. Hider
Keyword(s):  
Rich Source ◽  
Honeybee Venom ◽  
Active Peptides ◽  
Pharmacologically Active

Laricifomes officinalis – a rich source of pharmacologically active triterpenes

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381 ◽  
Author(s):  
S Sturm ◽  
K Gallmetzer ◽  
A Friedl ◽  
B Waltenberger ◽  
V Temml ◽  
...  
Keyword(s):  
Rich Source ◽  
Pharmacologically Active

scholarly journals Diversity of Conopeptides and Conoenzymes from the Venom Duct of the Marine Cone Snail Conus bayani as Determined from Transcriptomic and Proteomic Analyses

Marine Drugs ◽  
2021 ◽  
Vol 19 (4) ◽  
pp. 202
Author(s):  
Rajesh Rajaian Pushpabai ◽  
Carlton Ranjith Wilson Alphonse ◽  
Rajasekar Mani ◽  
Deepak Arun Apte ◽  
Jayaseelan Benjamin Franklin
Keyword(s):  
Gene Family ◽  
Transcriptome Sequencing ◽  
Cone Snail ◽  
Active Peptides ◽  
Transcriptomic Data ◽  
Sequencing Technologies ◽  
Hunting Strategies ◽  
Divergent Gene ◽  
Pharmacologically Active ◽  
Highly Evolved

Marine cone snails are predatory gastropods characterized by a well-developed venom apparatus and highly evolved hunting strategies that utilize toxins to paralyze prey and defend against predators. The venom of each species of cone snail has a large number of pharmacologically active peptides known as conopeptides or conotoxins that are usually unique in each species. Nevertheless, venoms of only very few species have been characterized so far by transcriptomic approaches. In this study, we used transcriptome sequencing technologies and mass spectrometric methods to describe the diversity of venom components expressed by a worm-hunting species, Conus bayani. A total of 82 conotoxin sequences were retrieved from transcriptomic data that contain 54 validated conotoxin sequences clustered into 21 gene superfamilies including divergent gene family, 17 sequences clustered to 6 different conotoxin classes, and 11 conotoxins classified as unassigned gene family. Seven new conotoxin sequences showed unusual cysteine patterns. We were also able to identify 19 peptide sequences using mass spectrometry that completely overlapped with the conotoxin sequences obtained from transcriptome analysis. Importantly, herein we document the presence of 16 proteins that include five post-translational modifying enzymes obtained from transcriptomic data. Our results revealed diverse and novel conopeptides of an unexplored species that could be used extensively in biomedical research due to their therapeutic potentials.

Pharmacologically Active Peptides and Proteins from Bee Venom

Animal Toxins ◽  
2000 ◽  
pp. 127-151
Author(s):  
Peter N. Strong ◽  
Jonathan D. F. Wadsworth
Keyword(s):  
Bee Venom ◽  
Active Peptides ◽  
Pharmacologically Active

scholarly journals Citrus Peels as a Source of Bioactive Compounds with Industrial and Therapeutic Applications

2021 ◽  
Author(s):  
Doha Hussien Abou Baker ◽  
Eman Ahmed Ibrahim ◽  
Zeinab Abd El-Rhaman Salama
Keyword(s):  
Bioactive Compounds ◽  
Antioxidant Activities ◽  
Rich Source ◽  
New Drugs ◽  
Active Metabolites ◽  
Citrus Peel ◽  
The World ◽  
Good Starting Point ◽  
Pharmacologically Active ◽  
Agriculture Wastes

Agriculture wastes are considered a good starting point to discover for new drugs all over the world. In this context, Agriculture wastes contain millions of compounds to be screened to find bioactive compounds responsible for the activity to be used in drugs. Citrus agriculture is one of the most important commercial and industrial agricultural activities in the world. The peel waste of Citrus species is a rich source of bioactive compounds such as essential oils, flavones, polyphenols, and pigment. Citrus peel has been widely used in the medicine industry. The waste peel of citrus consider a rich source of pharmacologically active metabolites with antioxidant activities.

scholarly journals Natural Bioactive Thiazole-Based Peptides from Marine Resources: Structural and Pharmacological Aspects

Marine Drugs ◽  
2020 ◽  
Vol 18 (6) ◽  
pp. 329
Author(s):  
Rajiv Dahiya ◽  
Sunita Dahiya ◽  
Neeraj Kumar Fuloria ◽  
Suresh Kumar ◽  
Rita Mourya ◽  
...  
Keyword(s):  
Binding Sites ◽  
Wide Spectrum ◽  
Structural Features ◽  
Complex Nature ◽  
Special Focus ◽  
Structural Components ◽  
Active Peptides ◽  
Peptide Interactions ◽  
Allosteric Binding Sites ◽  
Pharmacologically Active

Peptides are distinctive biomacromolecules that demonstrate potential cytotoxicity and diversified bioactivities against a variety of microorganisms including bacteria, mycobacteria, and fungi via their unique mechanisms of action. Among broad-ranging pharmacologically active peptides, natural marine-originated thiazole-based oligopeptides possess peculiar structural features along with a wide spectrum of exceptional and potent bioproperties. Because of their complex nature and size divergence, thiazole-based peptides (TBPs) bestow a pivotal chemical platform in drug discovery processes to generate competent scaffolds for regulating allosteric binding sites and peptide–peptide interactions. The present study dissertates on the natural reservoirs and exclusive structural components of marine-originated TBPs, with a special focus on their most pertinent pharmacological profiles, which may impart vital resources for the development of novel peptide-based therapeutic agents.

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