Deficits of spatial learning and working memory in spontaneously hypertensive rats

1996 ◽  
Vol 74 (1-2) ◽  
pp. 217-221 ◽  
Author(s):  
E.M. Nakamura-Palacios ◽  
C.K. Caldas ◽  
A. Fiorini ◽  
K.D. Chagas ◽  
K.N. Chagas ◽  
...  
Keyword(s):  
Working Memory ◽  
Spatial Learning ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory

2016 ◽  
Vol 36 (9) ◽  
pp. 1592-1602 ◽  
Author(s):  
Akihiro Kitamura ◽  
Satoshi Saito ◽  
Takakuni Maki ◽  
Naoya Oishi ◽  
Takashi Ayaki ◽  
...  
Keyword(s):  
Working Memory ◽  
White Matter ◽  
Mortality Rate ◽  
Baseline Level ◽  
Spontaneously Hypertensive Rats ◽  
Spatial Working Memory ◽  
Small Vessel ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
White Matter Abnormalities

Rats subjected to bilateral common carotid arteries (CCAs) occlusion or 2-vessel occlusion (2VO) have been used as animal models of subcortical ischemic vascular dementia (SIVD). However, these models possess an inherent limitation in that cerebral blood flow (CBF) drops sharply and substantially after ligation of CCAs without vascular risk factors and causative small vessel changes. We previously reported a novel rat model of 2-vessel gradual occlusion (2VGO) in which ameroid constrictors (ACs) were placed bilaterally in the CCAs of Wistar-Kyoto rats. To simulate SIVD pathology more closely, we applied ACs in spontaneously hypertensive rats (SHRs), which naturally develop small vessel pathology, and compared their phenotypes with SHR-2VO and sham-operated rats. The mortality rate of the SHR-2VGO was 0% while that of the SHR-2VO was 56.5%. The CBF of the SHR-2VO dropped to 50% of the baseline level at 3 h, whereas the SHR-2VGO showed a gradual CBF reduction reaching only 68% of the baseline level at seven days. The SHR-2VGO showed slowly evolving white matter abnormalities and subsequent spatial working memory impairments of a similar magnitude to the remaining SHR-2VO at 28 days. We suggest the SHR-2VGO robustly replicates selective aspects of the pathophysiology of SIVD with low mortality rate.

scholarly journals Physiological and Behavioral Effects of d-threo-methylphenidate Hydrochloride in Male Wistar-Kyoto and Spontaneously Hypertensive Rats

2003 ◽  
Vol 2 (2) ◽  
Author(s):  
Jennifer Sayler ◽  
Linda Tennison ◽  
David Mitchell
Keyword(s):  
Working Memory ◽  
Spontaneously Hypertensive Rats ◽  
Spatial Working Memory ◽  
Membrane Lipids ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Glucose Levels ◽  
Wky Rats ◽  
Physiological Properties ◽  
Wistar Kyoto

Millions of children and adults worldwide are diagnosed with Attention-deficit hyperactivity disorder (ADHD) and yet its very existence, definition, and treatment are surrounded with discord and controversy. ADHD and its treatments are brought together through this investigation into the effects that drug therapy has on Wistar Kyoto rats (WKY) and a strain of Spontaneously Hypertensive rats (SHR) selectively inbred from WKY rats. The effects of the drug d-threo-methylphenidate hydrochloride (d-MPH - the d-isomer of the ADHD drug Ritalin) on spatial working memory abilities, overall growth rate, blood glucose levels, blood pH, and erythrocyte membrane lipids were examined in the two rat strains. Although all four physiological properties remained constant and normal over the course of the experiment, the spatial working memory abilities were inhibited in WKY rats receiving the drug. These results suggest that the d-isomer of this drug may have a significant impact on cognitive function in rats and possibly humans.

Biomembrane Characteristics in Stroke-prone Spontaneously Hypertensive Rats (SHRSP)

1978 ◽  
Vol 19 (4) ◽  
pp. 597-598 ◽  
Author(s):  
Yukio YAMORI ◽  
Yasuo NARA ◽  
Ryoichi HORIE ◽  
Michiya OHTAKA ◽  
Kiyoe OHTA ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Enhanced Emotional Response in Stroke-Prone Spontaneously Hypertensive Rats

1991 ◽  
Vol 32 (4) ◽  
pp. 579-579 ◽  
Author(s):  
Sawako Kobayashi ◽  
Tomoyo Tanaka ◽  
Tetsuo Akai ◽  
Motonori Yamaguchi ◽  
Hiroshi Ogawa ◽  
...  
Keyword(s):  
Emotional Response ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive
Sign in / Sign up

Export Citation Format

Share Document