Long-term depletion of brain histamine induced by α-fluoromethylhistidine increases feeding-associated locomotor activity in mice with a modulation of brain amino acid levels

1995 ◽  
Vol 72 (1-2) ◽  
pp. 83-88 ◽  
Author(s):  
Naruhiko Sakai ◽  
Eiichi Sakurai ◽  
Kenji Onodera ◽  
Eiko Sakurai ◽  
Hiroshi Asada ◽  
...  
Keyword(s):  
Amino Acid ◽  
Locomotor Activity ◽  
Brain Histamine ◽  
Amino Acid Levels ◽  
Brain Amino Acid

Depletion of brain histamine induced by α -fluoromethylhistidine enhances radial maze performance in rats with modulation of brain amino acid levels

Life Sciences ◽  
1998 ◽  
Vol 62 (11) ◽  
pp. 989-994 ◽  
Author(s):  
Naruhiko Sakai ◽  
Eiichi Sakurai ◽  
Eiko Sakurai ◽  
Kazuhiko Yanai ◽  
Yukio Miura ◽  
...  
Keyword(s):  
Amino Acid ◽  
Radial Maze ◽  
Maze Performance ◽  
Brain Histamine ◽  
Radial Maze Performance ◽  
Amino Acid Levels ◽  
Brain Amino Acid

Amino Acid Absorption following Intraperitoneal Administration in CAPD Patients

1981 ◽  
Vol 2 (3) ◽  
pp. 124-130 ◽  
Author(s):  
Paul F. Williams ◽  
Errol B. Marliss ◽  
G. Harvey Anderson ◽  
Arie Oren ◽  
Arthur N. Stein ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Acid Solution ◽  
Intraperitoneal Administration ◽  
Amino Acid Solution ◽  
Dialysis Solution ◽  
Term Administration ◽  
Osmotic Agent ◽  
Amino Acid Levels

Six non-diabetic CAPD patients were infused over six hours with two litres of a dialysis solution containing 2 g/ dl amino acids (a mixture of essentials and non-essentials). The osmolality of the solution and the amount of ultrafiltration it induced were simiiar to that of a 4.25 g% dextrose Dianeal solution (control), suggesting that an amino acid solution is an efficient osmotic agent. By the end of the six-hour infusion, 80 to 90% of the amino acids present in the dialysis solution had been absorbed. One hour after the infusion was instituted, plasma amino acid levels increased threefold and subsequently decreased to near the initial value by the sixth hour. The amino acid solution was as effective as the dextrose solution in removing urea nitrogen, creatinine and potassium. Our data indicate that intraperitoneal administration of amino acids is effective and well-tolerated in patients on CAPD. We believe further work should be done to determine whether long-term administration of amino acids by this route will improve the nutritional status of these patients and prevent the side effects of daily absorption of large amounts of glucose.

Hepatic amino acid levels in rats after long-term ethanol feeding

1979 ◽  
Vol 28 (3) ◽  
pp. 423-427 ◽  
Author(s):  
Jørg Mørland ◽  
Ragnar Flengsrud ◽  
Hans Prydz ◽  
Lene Svendsen
Keyword(s):  
Amino Acid ◽  
Ethanol Feeding ◽  
Amino Acid Levels

The effect of insulin deficiency, dietary protein intake, and plasma amino acid concentrations on brain amino acid levels in rats

1985 ◽  
Vol 63 (5) ◽  
pp. 487-494 ◽  
Author(s):  
N. Theresa Glanville ◽  
G. Harvey Anderson
Keyword(s):  
Amino Acid ◽  
Dietary Protein ◽  
Protein Intake ◽  
Plasma Amino Acid ◽  
Dietary Protein Intake ◽  
Influx Rate ◽  
Amino Acid Levels ◽  
The Brain ◽  
Amino Acid Concentrations ◽  
Brain Amino Acid

The effect of diabetes (streptozotocin, 65 mg/kg ip), dietary protein intake (15–60%), and plasma amino acid concentrations on brain large neutral amino acid levels in rats was examined. After 20 days, the plasma concentrations of methionine and the branched chain amino acids (BCAA), valine, isoleucine, and leucine were increased in diabetic rats. In brain tissue, methionine and valine levels were increased but threonine, tyrosine, and tryptophan concentrations were depressed. Increased protein consumption promoted a diabetic-like plasma amino acid pattern in normal rats while enhancing that of diabetic animals. However, with the exception of threonine, glycine, valine, and tyrosine, there was little effect on brain amino acid levels. A good association was found between the calculated brain influx rate and the actual brain concentration of threonine, methionine, tyrosine, and tryptophan in diabetic animals. There was no correlation, however, between brain influx rate and brain BCAA levels. Thus, the brain amino acid pattern in diabetes represents the combined effects of insulin insufficiency and composition of the diet ingested on plasma amino acid levels as well as metabolic adaptation within the brain itself.

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