Characterization of the membrane-bound protein kinase C and its substrate proteins in canine cardiac sarcolemma

1986 ◽  
Vol 886 (1) ◽  
pp. 152-161 ◽  
Author(s):  
Shaohua Yuan ◽  
Amar K. Sen
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cardiac Sarcolemma ◽  
Kinase C ◽  
Membrane Bound ◽  
Substrate Proteins

Endogenous substrates of rat heart protein kinase C type I, II, and III isozymic forms in cardiac sarcolemma

1992 ◽  
Vol 70 (1) ◽  
pp. 81-85 ◽  
Author(s):  
Yi Qu ◽  
Joseph Torchia ◽  
Thanh Duc Phan ◽  
Po Hsiung Wu ◽  
Amar Kumar Sen
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Type I ◽  
Type Ii ◽  
Cardiac Cell ◽  
Cardiac Sarcolemma ◽  
Kinase C ◽  
Endogenous Substrate ◽  
Endogenous Substrates ◽  
Substrate Proteins

The endogenous substrate proteins of rat cardiac protein kinase C type I, II, and III isozymic forms were studied in rat cardiac sarcolemma. The 19-, 21-, 29-, 35-, and 95-kDa proteins were phosphorylated by both types II and III, but not type I. The extent of phosphorylation by individual protein kinase C isozymic forms was additive and equal to the extent of phosphorylation observed when a mixture of isozymic forms was employed. The extent of phosphorylation of the 21-kDa protein by type III was much higher than that by type II. These results suggest that the protein kinase C isozymes have preferences for specific endogenous substrate proteins. The phosphorylation of these endogenous substrate proteins by protein kinase C isozymes probably plays a role in cardiac cell functions.Key words: cardiac sarcolemma, protein kinase C isozymes, phosphorylation, substrate proteins.

scholarly journals Amino acid sequence and characterization of a protein inhibitor of protein kinase C.

1990 ◽  
Vol 265 (8) ◽  
pp. 4583-4591 ◽  
Author(s):  
J D Pearson ◽  
D B DeWald ◽  
W R Mathews ◽  
N M Mozier ◽  
H A Zürcher-Neely ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Amino Acid ◽  
Protein Kinase ◽  
Amino Acid Sequence ◽  
Protein Inhibitor ◽  
Kinase C

scholarly journals Identification and functional characterization of protein kinase C isozymes in platelets and HEL cells.

1992 ◽  
Vol 267 (14) ◽  
pp. 10011-10017
Author(s):  
J Grabarek ◽  
M Raychowdhury ◽  
K Ravid ◽  
K.C. Kent ◽  
P.J. Newman ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Functional Characterization ◽  
Kinase C ◽  
Hel Cells

Purification and Characterization of Protein Kinase C from a Higher Plant, Brassica campestris L

1994 ◽  
Vol 203 (1) ◽  
pp. 311-318 ◽  
Author(s):  
T. Nanmori ◽  
W. Taguchi ◽  
M. Kinugasa ◽  
Y. Oji ◽  
S. Sahara ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Brassica Campestris ◽  
Purification And Characterization ◽  
Higher Plant ◽  
Kinase C
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