Differences in the E3 regions of the canine adenovirus type 1 and type 2

1992 ◽  
Vol 23 (1-2) ◽  
pp. 119-133 ◽  
Author(s):  
Tommy Linné
Keyword(s):  
1994 ◽  
Vol 75 (6) ◽  
pp. 1311-1317 ◽  
Author(s):  
C. Jacques ◽  
L. Cousineau ◽  
B. D'Amours ◽  
G. Lussier ◽  
C. Hamelin

2007 ◽  
Vol 18 (5) ◽  
pp. 277-283 ◽  
Author(s):  
Adriana Garozzo ◽  
Christian CC Cutri ◽  
Christophe Pannecouque ◽  
Angelo Castro ◽  
Francesco Guerrera ◽  
...  

We recently described the synthesis and antiviral activity of the compounds 5-phenyl-3-(4-cyano-5-phenylisothiazol-3-yl) disulphanyl-4-isothiazole-carbonitrile and S-(4-cyano-5-phenylisothiazol-3-yl)- O-ethyl thiocarbonate, which were found to be effective against both HIV-1 (IIIB) and HIV-2 (ROD). We have now evaluated these compounds against both RNA and DNA viruses, obtaining high selectivity indexes for poliovirus 1 (SI: 223 and 828, respectively) and Echovirus 9 (SI: 334 and 200, respectively). In our previous studies, 3-methylthio-5-(4- OBn-phenyl)-4-isothiazolecarbo-nitrile was found to exhibit a broad spectrum of action against picornaviruses, we therefore selected this compound and S-(4-cyano-5-phenylisothiazol-3-yl)- O-ethyl thiocarbonate as the model for the synthesis of a new isothiazole derivative, S-[4-cyano-5-(4- OBn-phenyl)isothiazol-3-yl]- O-ethyl thiocarbonate. This compound was evaluated against picornaviruses, measles virus, HIV-1 (IIIB) and HIV-2 (ROD), and some DNA viruses (adenovirus type 2 and herpes simplex virus type 1). The compound was shown to be active against rhinoviruses 2, 39, 86 and 89, Coxsackie B1 and measles virus.


2013 ◽  
Vol 162 (2-4) ◽  
pp. 551-557 ◽  
Author(s):  
Andrea Balboni ◽  
Ranieri Verin ◽  
Federico Morandi ◽  
Alessandro Poli ◽  
Santino Prosperi ◽  
...  

2008 ◽  
Vol 38 (15) ◽  
pp. 18
Author(s):  
SHERRY BOSCHERT
Keyword(s):  

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