Afferent conditioning of motor evoked potentials following transcranial magnetic stimulation of motor cortex in normal subjects

Author(s):  
T. Kasai ◽  
K.C. Hayes ◽  
D.L. Wolfe ◽  
R.D. Allatt
2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Aulikki Ahlgrén-Rimpiläinen ◽  
Hannu Lauerma ◽  
Seppo Kähkönen ◽  
Ilpo Rimpiläinen

Aims. Schizophrenia is a neuropsychiatric disorder associated with mental and motor disturbances. We aimed to investigate motor control, especially central silent period (CSP) in subjects with schizophrenia (n=11) on long-term antipsychotic treatment compared to healthy controls (n=9). Methods. Latency and duration of motor evoked potentials (MEPs) and CSPs were measured with the help of single pulse transcranial magnetic stimulation (TMS) and intramuscular electrodes. After stimulation of the dominant and nondominant motor cortex of abductor digiti minimi (ADM) and tibialis anterior (TA) muscle areas, respective responses were measured on the contralateral side. Results. MEPs did not differ significantly between the groups. Multiple CSPs were found predominantly in subjects with schizophrenia, which showed a higher number of CSPs in the dominant ADM and the longest summarized duration of CSPs in the nondominant ADM (P<0.05) compared to controls. Conclusions. There were multiple CSPs predominantly in the upper extremities and in the dominant body side in subjects with schizophrenia. Behind multiple CSPs may lie an impaired regulation of excitatory or inhibitory neurotransmitter systems in central motor pathways. Further research is needed to clarify the role of the intramuscular recording methods and the effect of antipsychotics on the results.


2002 ◽  
Vol 25 (3) ◽  
pp. 448-452 ◽  
Author(s):  
Pietro Balbi ◽  
Anna Perretti ◽  
Marilena Sannino ◽  
Lucia Marcantonio ◽  
Lucio Santoro

1995 ◽  
Vol 73 (6) ◽  
pp. 2608-2611 ◽  
Author(s):  
L. Fadiga ◽  
L. Fogassi ◽  
G. Pavesi ◽  
G. Rizzolatti

1. We stimulated the motor cortex of normal subjects (transcranial magnetic stimulation) while they 1) observed an experimenter grasping 3D-objects, 2) looked at the same 3D-objects, 3) observed an experimenter tracing geometrical figures in the air with his arm, and 4) detected the dimming of a light. Motor evoked potentials (MEPs) were recorded from hand muscles. 2. We found that MEPs significantly increased during the conditions in which subjects observed movements. The MEP pattern reflected the pattern of muscle activity recorded when the subjects executed the observed actions. 3. We conclude that in humans there is a system matching action observation and execution. This system resembles the one recently described in the monkey.


1995 ◽  
Vol 112 (4) ◽  
pp. 520-525 ◽  
Author(s):  
Agustín Campos ◽  
Rafael Barona ◽  
Joaquín Escudero ◽  
José Montalt ◽  
Manuel Escudero

The introduction of transcranial magnetic stimulation has allowed the study of conduction in the proximal portions and central pathways of the cranial nerves. A study is made of cranial nerve XII with transcranial magnetic stimulation at two levels, cortical and cisternal, registering the motor evoked potential by means of surface electrodes in contact with the upper face of the tongue. Motor evoked potentials were constantly observed on cortical stimulation, in a painless, easy, and reproducible way, with mean values of 10.84 ± 1.14 milliseconds (latency) and 7.81 ± 1.14 mV (amplitude). Motor evoked potentials were unconstant and showed reduced amplitues on cisternal stimulation, with mean values of 4.72 ± 0.62 milliseconds and 0.83 ± 1.26 mV. The magnetic stimulation technique allows the study of the entire motor pathway of cranial nerve XII (motor cortex-medulla, motoneuron-muscle). The method is efficient, noninvasive, painless, and easily reproduced, and it comes close to being an ideal clinical conduction study technique for this cranial nerve.


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